Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.
NCT02020421 · ClinicalTrials.gov registry record · NA
NOn-invasive Repeated THerapeutic STimulation for Aphasia Recovery
A NA study of Aphasia, sponsored by Dr. Alexander Thiel.
- Completed
- Registry status
- NA
- Development phase
- 63
- Enrollment target
- 6
- Study locations
NCT02020421 is a NA study of Aphasia that has completed, run by Dr. Alexander Thiel. The registered enrollment target is 63 participants, below the 82-participant average among 42 other Aphasia trials with a reported enrollment target (23% lower). The trial reports 6 study locations across 4 states.
The verdict
NCT02020421, a NA study of Aphasia, has completed, sponsored by Dr. Alexander Thiel.
- COMPLETED
- Registry status
- NA
- Development phase
- 63 participants
- Enrollment target
- 6
- Study locations
Study Summary
The current standard of care for rehabilitation of patients with aphasia after stroke is conventional speech and language therapy (SLT). Due to economic realities on most stroke units, SLT can often not be given with optimal intensity in the first weeks after the stroke. Developing new adjuvant therapies which may render SLT sessions more effective is thus one approach to improve rehabilitation outcome. Recent functional imaging studies in post-stroke aphasia have shown that the recruitment of brain regions in the unaffected hemisphere seems to be an inferior strategy for recovery of language function as compared to re-activation of brain regions in the vicinity of the infarct. Non-invasive brain stimulation techniques, such as repetitive transcranial magnetic stimulation (rTMS) or transcranial direct current stimulation (tDCS) are new methods to modulate brain activity. Evidence from our own feasibility study in sub-acute stroke suggests that these new techniques, when applied in conjunction with conventional SLT, may help to normalize brain activation patterns and might yield better rehabilitation outcome than SLT alone. With NORTHSTAR, we propose a multicenter proof-of-concept study to investigate the safety, feasibility and efficacy of these new non-invasive brain stimulation methods as adjuvant therapies for subacute post-stroke aphasia. Our goal is to determine the most effective brain stimulation modality to decrease inhibition onto the left side of the brain. We will assess if a combination of brain stimulation and speech and language therapy will improve language recovery. We will quantify language recovery (expressive and comprehensive skills) using specific tests, commonly used by speech and language therapists. We will invite patients recently admitted to the stroke unit of the study centers to participate in our research project. Once patients consent to our study we will randomly assign them to one of three experimental groups. For 12 days, all group
Conditions Studied
Interventions
- DEVICE Sham tDCS
- DEVICE Sham rTMS
- DEVICE tDCS
- DEVICE rTMS
Study Locations (6)
Ontario
- Sunnybrook Research Institute - Toronto
- Toronto Rehabilitation Institute - UHN - Toronto
Quebec
- CHUM Notre-Dame - Montreal
- Jewish General Hospital - Montreal
New York
- Burke-Cornell Medical Research Institute - White Plains
Other
- Max-Planck-Institut für neurologische Forschung - Cologne
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 63 participants |
| Start Date | 2013-12 |
| Est. Completion | 2018-03 |
| Phase | NA |
Interested in This Trial?
Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT02020421
The ClinicalTrials.gov registry entry for NCT02020421 describes a study currently listed as completed, categorized as NA. The registered enrollment target is 63 participants, a figure that helps gauge the scale of data the investigators plan to collect, below the 82-participant average among 42 other Aphasia trials with a reported enrollment target (23% lower). The listed sponsor is Dr. Alexander Thiel, which has 1 total studies on file at ClinicalTrials.gov.
The record links to 1 condition, with Aphasia appearing as the primary indexed condition, and to 4 interventions - of which Sham tDCS is the first listed.
NCT02020421 reports 6 study locations spanning 4 distinct geographic areas - top geographies include Ontario, Quebec, New York.
Frequently Asked Questions
What is clinical trial NCT02020421 about?
NCT02020421 is a clinical study titled "NOn-invasive Repeated THerapeutic STimulation for Aphasia Recovery". The current standard of care for rehabilitation of patients with aphasia after stroke is conventional speech and language therapy (SLT). Due to economic realities on most stroke units, SLT can often not be given with optimal intensity in the first weeks after the stroke. Developing new adjuvant ther...
What is the current status of trial NCT02020421?
This trial is currently completed. It is a NA study. The enrollment target is 63 participants. The study started on 2013-12. Estimated completion is 2018-03.
What conditions does trial NCT02020421 study?
This clinical trial studies the following conditions: Aphasia.
What interventions are being tested in trial NCT02020421?
The interventions under investigation include: Sham tDCS (DEVICE), Sham rTMS (DEVICE), tDCS (DEVICE), rTMS (DEVICE).
Who is sponsoring clinical trial NCT02020421?
This trial is sponsored by Dr. Alexander Thiel, which has 1 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT02020421 being conducted?
This trial has 6 study locations across New York, Ontario, Quebec. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Aphasia
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
-
Transcranial Direct Current Stimulation (tDCS) With Verb Network Strengthening Treatment (VNeST) in Chronic Aphasia
RECRUITING · NA
-
Transcranial Alternating Current Stimulation (tACS) in Aphasia
RECRUITING · NA
-
tACS to Enhance Language Abilities
RECRUITING · NA
-
Treatment Outcomes With tDCS in Post-Stroke Aphasia
RECRUITING · NA
-
Telerehabilitation for Aphasia (TERRA)
RECRUITING · NA
-
Combined Exercise and Targeted Therapy for Post-Stroke Reading Deficits
RECRUITING · NA
Read our methodology - how this data is sourced, computed, and verified.
Related
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page mirrors this trial's own ClinicalTrials.gov registry record, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.