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NCT07220265 · ClinicalTrials.gov registry record · NA

Impact of Phenylalanine Elevations on Brain and Cognition in Adult PKU Carriers

A NA study of Healthy and Carrier of Phenylketonuria, sponsored by University of Missouri-Columbia.

Recruiting
Registry status
NA
Development phase
36
Enrollment target
1
Study location

NCT07220265 is a NA study of Healthy and Carrier of Phenylketonuria that is actively recruiting participants, run by University of Missouri-Columbia. The registered enrollment target is 36 participants, below the 647-participant average among 1,090 other Healthy trials with a reported enrollment target (94% lower). The trial reports 1 study location across 1 state.

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The verdict

NCT07220265, a NA study of Healthy and Carrier of Phenylketonuria, is actively recruiting participants, sponsored by University of Missouri-Columbia.

RECRUITING
Registry status
NA
Development phase
36 participants
Enrollment target
1
Study location

Study Summary

The goal of this clinical trial is to advance our understanding of the cognitive and neurophysiologic sequelae associated with suboptimal phenylalanine (Phe) metabolism in heterozygous carriers of phenylketonuria (PKU). The main questions it aims to answer are: * Do PKU carriers experience prolonged elevations in brain Phe levels following oral ingestion of dietary Phe? * Do PKU carriers experience disruptions in cognitive functioning following oral ingestion of dietary Phe? * Do PKU carriers experience atypical brain activity following oral ingestion of dietary Phe? Researchers will compare PKU carriers and non-carriers following oral ingestion of dietary Phe and a placebo. Participants will: * Consume Phe or a placebo at two separate visits to our facility * At each visit, they will complete a series of MRIs and cognitive tests throughout the day

Conditions Studied

Healthy Carrier of Phenylketonuria

Interventions

  • DIETARY_SUPPLEMENT Placebo
  • DIETARY_SUPPLEMENT Phenylalanine (Phe)

Study Locations (1)

Missouri

  • University of Missouri-Columbia - Columbia

Trial Details

FieldValue
Enrollment Target 36 participants
Start Date 2025-12-19
Est. Completion 2026-12-31
Phase NA

Sponsor

University of Missouri-Columbia

291 total trials

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What the Registry Record Tells You About NCT07220265

The ClinicalTrials.gov registry entry for NCT07220265 describes a study currently listed as recruiting, categorized as NA. The registered enrollment target is 36 participants, a figure that helps gauge the scale of data the investigators plan to collect, below the 647-participant average among 1,090 other Healthy trials with a reported enrollment target (94% lower). The listed sponsor is University of Missouri-Columbia, which has 291 total studies on file at ClinicalTrials.gov.

The record links to 2 conditions, with Healthy appearing as the primary indexed condition, and to 2 interventions - of which Placebo is the first listed.

NCT07220265 reports 1 study location spanning 1 distinct geographic area - top geographies include Missouri.

Frequently Asked Questions

What is clinical trial NCT07220265 about?

NCT07220265 is a clinical study titled "Impact of Phenylalanine Elevations on Brain and Cognition in Adult PKU Carriers". The goal of this clinical trial is to advance our understanding of the cognitive and neurophysiologic sequelae associated with suboptimal phenylalanine (Phe) metabolism in heterozygous carriers of phenylketonuria (PKU). The main questions it aims to answer are: * Do PKU carriers experience prolonge...

What is the current status of trial NCT07220265?

This trial is currently recruiting. It is a NA study. The enrollment target is 36 participants. The study started on 2025-12-19. Estimated completion is 2026-12-31.

What conditions does trial NCT07220265 study?

This clinical trial studies the following conditions: Healthy, Carrier of Phenylketonuria.

What interventions are being tested in trial NCT07220265?

The interventions under investigation include: Placebo (DIETARY_SUPPLEMENT), Phenylalanine (Phe) (DIETARY_SUPPLEMENT).

Who is sponsoring clinical trial NCT07220265?

This trial is sponsored by University of Missouri-Columbia, which has 291 total clinical trials registered on ClinicalTrials.gov.

Where is trial NCT07220265 being conducted?

This trial has 1 study location across Missouri. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

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Data sourced from official public datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page mirrors this trial's own ClinicalTrials.gov registry record, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.