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NCT07216755 · ClinicalTrials.gov registry record · NA
Effects of Breathing Training and Nitrate on Exercise at Simulated Altitude
A NA study of Hypoxia and Healthy Adults, sponsored by Embry-Riddle Aeronautical University.
- Recruiting
- Registry status
- NA
- Development phase
- 80
- Enrollment target
- 1
- Study location
NCT07216755: Recruiting NA study of Hypoxia and Healthy Adults, sponsored by Embry-Riddle Aeronautical University.
NCT07216755 is a NA study of Hypoxia and Healthy Adults that is actively recruiting participants, run by Embry-Riddle Aeronautical University. The registered enrollment target is 80 participants, below the 3,115-participant average among 39 other Hypoxia trials with a reported enrollment target (97% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT07216755, a NA study of Hypoxia and Healthy Adults, is actively recruiting participants, sponsored by Embry-Riddle Aeronautical University.
- RECRUITING
- Registry status
- NA
- Development phase
- 80 participants
- Enrollment target
- 1
- Study location
Study Summary
This study investigates whether respiratory muscle training (RMT) and dietary nitrate supplementation can improve exercise tolerance under simulated moderate altitude conditions. Exposure to reduced oxygen availability at altitude places additional strain on the cardiovascular and respiratory systems, which may limit endurance performance. By combining RMT-designed to strengthen the muscles involved in breathing-with nitrate therapy, which enhances nitric oxide availability and vascular function, this study aims to determine whether these interventions independently or synergistically improve oxygen delivery, reduce physiological strain, and enhance exercise performance. The findings will help identify non-pharmacological strategies to improve physical performance and tolerance to hypoxia in both clinical and operational environments.
Primary Outcome
Exercise tolerance will be measured as the time to exhaustion during a graded cycling exercise test performed under simulated moderate altitude conditions (\~2,500-3,000 meters). Tests will be conducted before and after the 4-6 week intervention period. The measure reflects overall improvements in aerobic performance and fatigue resistance following respiratory muscle training, nitrate supplementation, or their combination.
Conditions Studied
Interventions
- DEVICE Respiratory Muscle Training (RMT)
- DEVICE Sham Respiratory Muscle Training
- DIETARY_SUPPLEMENT Dietary Supplement: Beetroot Juice Concentrate
- DIETARY_SUPPLEMENT placebo beverage
Study Locations (1)
Florida
- Embry-Riddle Aeronautical University - Daytona Beach
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 80 participants |
| Start Date | 2025-09-01 |
| Est. Completion | 2028-08-31 |
| Phase | NA |
What NCT07216755 shows while recruiting
NCT07216755 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 80 participants, a relatively small participant target, below the 3,115-participant average among 39 other Hypoxia trials with a reported enrollment target (97% lower).
The record links to 8 conditions, with Hypoxia appearing as the primary indexed condition, and to 4 interventions - of which Respiratory Muscle Training (RMT) is the first listed.
NCT07216755 reports a single indexed study location in Florida.
Frequently Asked Questions
What is clinical trial NCT07216755 about?
NCT07216755 is a clinical study titled "Effects of Breathing Training and Nitrate on Exercise at Simulated Altitude". This study investigates whether respiratory muscle training (RMT) and dietary nitrate supplementation can improve exercise tolerance under simulated moderate altitude conditions. Exposure to reduced oxygen availability at altitude places additional strain on the cardiovascular and respiratory system...
What is the current status of trial NCT07216755?
This trial is currently recruiting. It is a NA study. The enrollment target is 80 participants. The study started on 2025-09-01. Estimated completion is 2028-08-31.
What conditions does trial NCT07216755 study?
This clinical trial studies the following conditions: Hypoxia, Healthy Adults, Dietary Supplement, Exercise Training, Exercise Intolerance.
What interventions are being tested in trial NCT07216755?
The interventions under investigation include: Respiratory Muscle Training (RMT) (DEVICE), Sham Respiratory Muscle Training (DEVICE), Dietary Supplement: Beetroot Juice Concentrate (DIETARY_SUPPLEMENT), placebo beverage (DIETARY_SUPPLEMENT).
Who is sponsoring clinical trial NCT07216755?
This trial is sponsored by Embry-Riddle Aeronautical University, which has 2 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT07216755 being conducted?
This trial has 1 study location across Florida. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Hypoxia
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT07216755's enrollment target sits among peer trials
80 13th of 39 higher than 27 of 39 other Hypoxia trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Hypoxia trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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