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Effects of Breathing Training and Nitrate on Exercise at Simulated Altitude
NCT07216755 · View on ClinicalTrials.gov ↗
Study Summary
This study investigates whether respiratory muscle training (RMT) and dietary nitrate supplementation can improve exercise tolerance under simulated moderate altitude conditions. Exposure to reduced oxygen availability at altitude places additional strain on the cardiovascular and respiratory systems, which may limit endurance performance. By combining RMT-designed to strengthen the muscles involved in breathing-with nitrate therapy, which enhances nitric oxide availability and vascular function, this study aims to determine whether these interventions independently or synergistically improve oxygen delivery, reduce physiological strain, and enhance exercise performance. The findings will help identify non-pharmacological strategies to improve physical performance and tolerance to hypoxia in both clinical and operational environments.
Conditions Studied
Interventions
- DEVICE Respiratory Muscle Training (RMT)
- DEVICE Sham Respiratory Muscle Training
- DIETARY_SUPPLEMENT Dietary Supplement: Beetroot Juice Concentrate
- DIETARY_SUPPLEMENT placebo beverage
Study Locations (1)
Florida
- Embry-Riddle Aeronautical University — Daytona Beach
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 80 participants |
| Start Date | 2025-09-01 |
| Est. Completion | 2028-08-31 |
| Phase | NA |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT07216755
The ClinicalTrials.gov registry entry for NCT07216755 describes a study currently listed as recruiting. It is categorized as NA, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 80 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Embry-Riddle Aeronautical University, which has 30 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.
The record links to 8 conditions, with Hypoxia appearing as the primary indexed condition, and to 4 interventions — of which Respiratory Muscle Training (RMT) is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.
Geographic footprint matters for practical reasons: NCT07216755 reports 1 study location spanning 1 distinct geographic area — top geographies include Florida. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.
Frequently Asked Questions
What is clinical trial NCT07216755 about?
NCT07216755 is a clinical study titled "Effects of Breathing Training and Nitrate on Exercise at Simulated Altitude". This study investigates whether respiratory muscle training (RMT) and dietary nitrate supplementation can improve exercise tolerance under simulated moderate altitude conditions. Exposure to reduced oxygen availability at altitude places additional strain on the cardiovascular and respiratory system...
What is the current status of trial NCT07216755?
This trial is currently recruiting. It is a NA study. The enrollment target is 80 participants. The study started on 2025-09-01. Estimated completion is 2028-08-31.
What conditions does trial NCT07216755 study?
This clinical trial studies the following conditions: Hypoxia, Healthy Adults, Dietary Supplement, Exercise Training, Exercise Intolerance. These conditions were identified from the trial registry and reflect the primary focus areas of the research.
What interventions are being tested in trial NCT07216755?
The interventions under investigation include: Respiratory Muscle Training (RMT) (DEVICE), Sham Respiratory Muscle Training (DEVICE), Dietary Supplement: Beetroot Juice Concentrate (DIETARY_SUPPLEMENT), placebo beverage (DIETARY_SUPPLEMENT). Each intervention is being evaluated for safety and efficacy as part of this clinical study.
Who is sponsoring clinical trial NCT07216755?
This trial is sponsored by Embry-Riddle Aeronautical University, which has 30 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.
Where is trial NCT07216755 being conducted?
This trial has 1 study location across Florida. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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