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NCT07113067 · ClinicalTrials.gov registry record · Phase 1
Accelerated rTMS vs. Sham for Stroke Apathy
A Phase 1 study of Stroke and Motivation, sponsored by Medical University of South Carolina.
- Recruiting
- Registry status
- Phase 1
- Development phase
- 40
- Enrollment target
- 1
- Study location
NCT07113067: Recruiting Phase 1 study of Stroke and Motivation, sponsored by Medical University of South Carolina.
NCT07113067 is a Phase 1 study of Stroke and Motivation that is actively recruiting participants, run by Medical University of South Carolina. The registered enrollment target is 40 participants, below the 12,016-participant average among 454 other Stroke trials with a reported enrollment target (100% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT07113067, a Phase 1 study of Stroke and Motivation, is actively recruiting participants, sponsored by Medical University of South Carolina.
- RECRUITING
- Registry status
- Phase 1
- Development phase
- 40 participants
- Enrollment target
- 1
- Study location
Study Summary
Apathy is a common set of symptoms seen in many people following a stroke. Apathy occurs when a person has lost motivation, becomes withdrawn, and stops doing things that used to be important to them. Apathy has a large negative impact on a person's quality of life, and can also have a large impact the people who take care of them. There are currently no FDA-approved treatments to help with apathy, and other services like therapy may be difficult to access for people who have had a stroke. To address this problem, investigators are conducting a study to find out if a form of treatment called repetitive transcranial magnetic stimulation (rTMS) can be safe and helpful for people struggling with apathy after a stroke. This study will apply a new form of rTMS which can be delivered quickly to a part of the brain called the medial prefrontal cortex (mPFC). This study will help establish whether this treatment is safe, comfortable, and effective for people with apathy after a stroke, and will help researchers develop new forms of treatment.
Primary Outcome
The Lille Apathy Rating Scale (LARS) is a clinically validated 33-item structured interview assessing clinical symptoms of apathy. The structured interview is broken into 9 sub-scales including everyday productivity, interests, taking the initiative, novelty seeking, motivation, emotional responsiveness, concern, and social life. Total scores can range from -36 to +36 and are further stratified by factorial sub-scores including intellectual curiosity, emotion, action initiation, and self-awarene
Conditions Studied
Interventions
- DEVICE MagVenture MagPro Transcranial Magnetic Stimulation (TMS) System (Active)
- DEVICE MagVenture MagPro Transcranial Magnetic Stimulation (TMS) System (Sham)
- OTHER Brainsight Neuronavigation System
Study Locations (1)
South Carolina
- Medical University of South Carolina Brain Stimulation Lab - Charleston
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 40 participants |
| Start Date | 2025-08-08 |
| Est. Completion | 2027-06-30 |
| Phase | Phase 1 |
What NCT07113067 shows while recruiting
NCT07113067 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 40 participants, a relatively small participant target, below the 12,016-participant average among 454 other Stroke trials with a reported enrollment target (100% lower).
The record links to 7 conditions, with Stroke appearing as the primary indexed condition, and to 3 interventions - of which MagVenture MagPro Transcranial Magnetic Stimulation (TMS) System (Active) is the first listed.
NCT07113067 reports a single indexed study location in South Carolina.
Frequently Asked Questions
What is clinical trial NCT07113067 about?
NCT07113067 is a clinical study titled "Accelerated rTMS vs. Sham for Stroke Apathy". Apathy is a common set of symptoms seen in many people following a stroke. Apathy occurs when a person has lost motivation, becomes withdrawn, and stops doing things that used to be important to them. Apathy has a large negative impact on a person's quality of life, and can also have a large impact ...
What is the current status of trial NCT07113067?
This trial is currently recruiting. It is a Phase 1 study. The enrollment target is 40 participants. The study started on 2025-08-08. Estimated completion is 2027-06-30.
What conditions does trial NCT07113067 study?
This clinical trial studies the following conditions: Stroke, Motivation, Stroke Sequelae, Apathy, Stroke/Brain Attack.
What interventions are being tested in trial NCT07113067?
The interventions under investigation include: MagVenture MagPro Transcranial Magnetic Stimulation (TMS) System (Active) (DEVICE), MagVenture MagPro Transcranial Magnetic Stimulation (TMS) System (Sham) (DEVICE), Brainsight Neuronavigation System (OTHER).
Who is sponsoring clinical trial NCT07113067?
This trial is sponsored by Medical University of South Carolina, which has 755 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT07113067 being conducted?
This trial has 1 study location across South Carolina. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
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Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT07113067's enrollment target sits among peer trials
40 262nd of 454 higher than 181 of 454 other Stroke trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Stroke trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
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