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NCT06948136 · ClinicalTrials.gov registry record · Phase 1
Acute Effects of THC in Older Adult
A Phase 1 study of Age-related Cognitive Decline, sponsored by Yale University.
- Recruiting
- Registry status
- Phase 1
- Development phase
- 60
- Enrollment target
- 1
- Study location
NCT06948136: Recruiting Phase 1 study of Age-related Cognitive Decline, sponsored by Yale University.
NCT06948136 is a Phase 1 study of Age-related Cognitive Decline that is actively recruiting participants, run by Yale University. The registered enrollment target is 60 participants, below the 1,127-participant average among 10 other Age-related Cognitive Decline trials with a reported enrollment target (95% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT06948136, a Phase 1 study of Age-related Cognitive Decline, is actively recruiting participants, sponsored by Yale University.
- RECRUITING
- Registry status
- Phase 1
- Development phase
- 60 participants
- Enrollment target
- 1
- Study location
Study Summary
The primary objective of this study is to determine if increasing age confers greater vulnerability to the acute A) cognitive (e.g., memory, attention, psychomotor function), B) subjective (e.g., anxiogenic and rewarding effects), and C) cardiovascular (heart rate and blood pressure), effects of THC in adults \> 21 years old. The secondary aims of the study are to explore age-related acute effects of THC on electrophysiological indices of information processing (e.g., auditory steady-state response (ASSR), oddball paradigm \[P300\], and resting state cortical noise) and to determine age-related differences in the metabolism of THC.
Primary Outcome
The task consists of 5 trials, an interference list, free delayed recall, and recognition.
Conditions Studied
Interventions
- DRUG Placebo
- DRUG Delta-9-THC Low Dose
- DRUG Delta-9-THC Medium Dose
Study Locations (1)
Connecticut
- VA Connecticut Healthcare System - West Haven
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 60 participants |
| Start Date | 2025-06-06 |
| Est. Completion | 2027-11-01 |
| Phase | Phase 1 |
What NCT06948136 shows while recruiting
NCT06948136 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 60 participants, a relatively small participant target, below the 1,127-participant average among 10 other Age-related Cognitive Decline trials with a reported enrollment target (95% lower).
The record links to 1 condition, with Age-related Cognitive Decline appearing as the primary indexed condition, and to 3 interventions - of which Placebo is the first listed.
NCT06948136 reports a single indexed study location in Connecticut.
Frequently Asked Questions
What is clinical trial NCT06948136 about?
NCT06948136 is a clinical study titled "Acute Effects of THC in Older Adult". The primary objective of this study is to determine if increasing age confers greater vulnerability to the acute A) cognitive (e.g., memory, attention, psychomotor function), B) subjective (e.g., anxiogenic and rewarding effects), and C) cardiovascular (heart rate and blood pressure), effects of THC...
What is the current status of trial NCT06948136?
This trial is currently recruiting. It is a Phase 1 study. The enrollment target is 60 participants. The study started on 2025-06-06. Estimated completion is 2027-11-01.
What conditions does trial NCT06948136 study?
This clinical trial studies the following conditions: Age-related Cognitive Decline.
What interventions are being tested in trial NCT06948136?
The interventions under investigation include: Placebo (DRUG), Delta-9-THC Low Dose (DRUG), Delta-9-THC Medium Dose (DRUG).
Who is sponsoring clinical trial NCT06948136?
This trial is sponsored by Yale University, which has 1,492 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06948136 being conducted?
This trial has 1 study location across Connecticut. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Age-related Cognitive Decline
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT06948136's enrollment target sits among peer trials
60 8th of 10 higher than 3 of 10 other Age-related Cognitive Decline trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Age-related Cognitive Decline trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
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