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NCT06948136 · ClinicalTrials.gov registry record · Phase 1

Acute Effects of THC in Older Adult

A Phase 1 study of Age-related Cognitive Decline, sponsored by Yale University.

Recruiting
Registry status
Phase 1
Development phase
60
Enrollment target
1
Study location

NCT06948136 is a Phase 1 study of Age-related Cognitive Decline that is actively recruiting participants, run by Yale University. The registered enrollment target is 60 participants, below the 1,127-participant average among 10 other Age-related Cognitive Decline trials with a reported enrollment target (95% lower). The trial reports 1 study location across 1 state.

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The verdict

NCT06948136, a Phase 1 study of Age-related Cognitive Decline, is actively recruiting participants, sponsored by Yale University.

RECRUITING
Registry status
Phase 1
Development phase
60 participants
Enrollment target
1
Study location

Study Summary

The primary objective of this study is to determine if increasing age confers greater vulnerability to the acute A) cognitive (e.g., memory, attention, psychomotor function), B) subjective (e.g., anxiogenic and rewarding effects), and C) cardiovascular (heart rate and blood pressure), effects of THC in adults \> 21 years old. The secondary aims of the study are to explore age-related acute effects of THC on electrophysiological indices of information processing (e.g., auditory steady-state response (ASSR), oddball paradigm \[P300\], and resting state cortical noise) and to determine age-related differences in the metabolism of THC.

Conditions Studied

Age-related Cognitive Decline

Interventions

  • DRUG Placebo
  • DRUG Delta-9-THC Low Dose
  • DRUG Delta-9-THC Medium Dose

Study Locations (1)

Connecticut

  • VA Connecticut Healthcare System - West Haven

Trial Details

FieldValue
Enrollment Target 60 participants
Start Date 2025-06-06
Est. Completion 2027-11-01
Phase Phase 1

Sponsor

Yale University

1,492 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT06948136

The ClinicalTrials.gov registry entry for NCT06948136 describes a study currently listed as recruiting, categorized as Phase 1. The registered enrollment target is 60 participants, a figure that helps gauge the scale of data the investigators plan to collect, below the 1,127-participant average among 10 other Age-related Cognitive Decline trials with a reported enrollment target (95% lower). The listed sponsor is Yale University, which has 1,492 total studies on file at ClinicalTrials.gov.

The record links to 1 condition, with Age-related Cognitive Decline appearing as the primary indexed condition, and to 3 interventions - of which Placebo is the first listed.

NCT06948136 reports 1 study location spanning 1 distinct geographic area - top geographies include Connecticut.

Frequently Asked Questions

What is clinical trial NCT06948136 about?

NCT06948136 is a clinical study titled "Acute Effects of THC in Older Adult". The primary objective of this study is to determine if increasing age confers greater vulnerability to the acute A) cognitive (e.g., memory, attention, psychomotor function), B) subjective (e.g., anxiogenic and rewarding effects), and C) cardiovascular (heart rate and blood pressure), effects of THC...

What is the current status of trial NCT06948136?

This trial is currently recruiting. It is a Phase 1 study. The enrollment target is 60 participants. The study started on 2025-06-06. Estimated completion is 2027-11-01.

What conditions does trial NCT06948136 study?

This clinical trial studies the following conditions: Age-related Cognitive Decline.

What interventions are being tested in trial NCT06948136?

The interventions under investigation include: Placebo (DRUG), Delta-9-THC Low Dose (DRUG), Delta-9-THC Medium Dose (DRUG).

Who is sponsoring clinical trial NCT06948136?

This trial is sponsored by Yale University, which has 1,492 total clinical trials registered on ClinicalTrials.gov.

Where is trial NCT06948136 being conducted?

This trial has 1 study location across Connecticut. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

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Data sourced from official public datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page mirrors this trial's own ClinicalTrials.gov registry record, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.