Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.
NCT03848312 · ClinicalTrials.gov registry record · Phase 3
Preventing Alzheimer's With Cognitive Training
A Phase 3 study of Age-related Cognitive Decline and Alzheimer's Disease and Related Dementias, sponsored by University of South Florida.
- Recruiting
- Registry status
- Phase 3
- Development phase
- 7,600
- Enrollment target
- 7
- Study locations
NCT03848312: Recruiting Phase 3 study of Age-related Cognitive Decline and Alzheimer's Disease and Related Dementias, sponsored by University of South Florida.
NCT03848312 is a Phase 3 study of Age-related Cognitive Decline and Alzheimer's Disease and Related Dementias that is actively recruiting participants, run by University of South Florida. The registered enrollment target is 7,600 participants, above the 373-participant average among 10 other Age-related Cognitive Decline trials with a reported enrollment target (1938% higher). The trial reports 7 study locations across 3 states. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT03848312, a Phase 3 study of Age-related Cognitive Decline and Alzheimer's Disease and Related Dementias, is actively recruiting participants, sponsored by University of South Florida.
- RECRUITING
- Registry status
- Phase 3
- Development phase
- 7,600 participants
- Enrollment target
- 7
- Study locations
Study Summary
Dementia is the most expensive medical condition in the US and increases in prevalence with age. More than 5 million Americans have Alzheimer's disease, the most common form of dementia. Mild cognitive impairment is a transitional stage between normal cognitive aging and Alzheimer's disease or another type of dementia, and is indicative of higher risk for dementia. In addition to the obvious health and quality-of-life ramifications of dementia, there are high direct (e.g., subsidizing residential care needs) and indirect (e.g., lost productivity of family caregivers) economic costs. Implementing interventions to prevent MCI and dementia among older adults is of critical importance to health and maintained quality-of-life for millions of Americans. Recent data analyses from the Advanced Cognitive Training in Vital Elderly study (ACTIVE) indicate that a specific cognitive intervention, speed of processing training (SPT), significantly delays the incidence of cognitive impairment across 10 years. The primary contribution of the proposed research will be the determination of whether this cognitive training technique successfully delays the onset of clinically defined MCI or dementia across three years.
Primary Outcome
clinical diagnosis of mild cognitive impairment or dementia
Conditions Studied
Interventions
- BEHAVIORAL Cognitive Training
- BEHAVIORAL Computerized Cognitive Stimulation
Study Locations (7)
Florida
- University of Florida - Gainesville
- University of Florida - Jacksonville
- University of North Florida - Jacksonville
- The Roskamp Institute - Sarasota
- University of South Florida - Tampa
North Carolina
- Duke Health - Durham
South Carolina
- Clemson University Institute for Engaged Aging - Seneca
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 7,600 participants |
| Start Date | 2019-02-19 |
| Est. Completion | 2026-01-31 |
| Phase | Phase 3 |
What NCT03848312 shows while recruiting
NCT03848312 is an interventional study that assigns participants to a tested intervention. Its 7,600 participants enrollment target places it among the larger protocols in the corpus, above the 373-participant average among 10 other Age-related Cognitive Decline trials with a reported enrollment target (1938% higher).
The record links to 2 conditions, with Age-related Cognitive Decline appearing as the primary indexed condition, and to 2 interventions - of which Cognitive Training is the first listed.
NCT03848312 lists 7 locations in 3 states (Florida, North Carolina, South Carolina).
Frequently Asked Questions
What is clinical trial NCT03848312 about?
NCT03848312 is a clinical study titled "Preventing Alzheimer's With Cognitive Training". Dementia is the most expensive medical condition in the US and increases in prevalence with age. More than 5 million Americans have Alzheimer's disease, the most common form of dementia. Mild cognitive impairment is a transitional stage between normal cognitive aging and Alzheimer's disease or anoth...
What is the current status of trial NCT03848312?
This trial is currently recruiting. It is a Phase 3 study. The enrollment target is 7,600 participants. The study started on 2019-02-19. Estimated completion is 2026-01-31.
What conditions does trial NCT03848312 study?
This clinical trial studies the following conditions: Age-related Cognitive Decline, Alzheimer's Disease and Related Dementias.
What interventions are being tested in trial NCT03848312?
The interventions under investigation include: Cognitive Training (BEHAVIORAL), Computerized Cognitive Stimulation (BEHAVIORAL).
Who is sponsoring clinical trial NCT03848312?
This trial is sponsored by University of South Florida, which has 252 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT03848312 being conducted?
This trial has 7 study locations across Florida, North Carolina, South Carolina. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Age-related Cognitive Decline
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT03848312's enrollment target sits among peer trials
7,600 1st of 10 higher than 10 of 10 other Age-related Cognitive Decline trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Age-related Cognitive Decline trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
-
Older Breast Cancer Patients: Risk for Cognitive Decline
RECRUITING
-
Acute Effects of THC in Older Adult
RECRUITING · Phase 1
-
Feasibility and Adherence to a Technology-assisted Home-based Strength Training Program in Adults With Type 2 Diabetes Mellitus and Mild Cognitive Impairment
RECRUITING · NA
-
The Active Mind Trial: An Adaptive Randomized Trial to Improve Function and Delay Dementia
RECRUITING · NA
-
Cardiac-Control Affecting Learning Through Mindfulness (CALM)
RECRUITING · NA
-
Brain Enhancement Training Towards Elders Resilience to Aging, Phase IIB
COMPLETED · NA
Nationwide trials with similar profiles
Cross-condition peers matched on enrollment target and registry start date, not the same-condition list above.
Similar enrollment target
- NCT06560398 · 7,649 participants · NA
Working Through Outreach, Navigation and Digital Enabled Referral and Recruitment Strategies (ACT WONDER²S)
- NCT00439049 · 7,500 participants
Substance Abuse Pre-Treatment Screening Study
- NCT04809740 · 7,500 participants · NA
Evaluating the Implementation and Impact of Navigator-delivered ePRO System
- NCT05199701 · 7,500 participants · NA
Prospective Case Collection Study for New Mammography Technologies
Similar registry start date
- NCT05962346 · started 2026-12 · NA
Fetal Endoscopic Tracheal Occlusion for Congenital Diaphragmatic Hernia
- NCT07125183 · started 2026-12 · Phase 2
Study on Efficacy and Tolerability of Weekly Doxorubicin in Elderly Patients With Advanced or Metastatic Leiomyosarcoma
- NCT07292298 · started 2026-11 · Phase 2
Phase 2 Single-Arm Rectal Cancer Brachytherapy for Patients With Low-Lying Residual Adenocarcinoma After Total Neoadjuvant Therapy to Improve Organ Preservation Rates
- NCT04263285 · started 2026-10 · NA
Treatment of Depression Post-SCI