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RECRUITING Phase 3

Preventing Alzheimer's With Cognitive Training

NCT03848312 · View on ClinicalTrials.gov ↗

Study Summary

Dementia is the most expensive medical condition in the US and increases in prevalence with age. More than 5 million Americans have Alzheimer's disease, the most common form of dementia. Mild cognitive impairment is a transitional stage between normal cognitive aging and Alzheimer's disease or another type of dementia, and is indicative of higher risk for dementia. In addition to the obvious health and quality-of-life ramifications of dementia, there are high direct (e.g., subsidizing residential care needs) and indirect (e.g., lost productivity of family caregivers) economic costs. Implementing interventions to prevent MCI and dementia among older adults is of critical importance to health and maintained quality-of-life for millions of Americans. Recent data analyses from the Advanced Cognitive Training in Vital Elderly study (ACTIVE) indicate that a specific cognitive intervention, speed of processing training (SPT), significantly delays the incidence of cognitive impairment across 10 years. The primary contribution of the proposed research will be the determination of whether this cognitive training technique successfully delays the onset of clinically defined MCI or dementia across three years.

Interventions

  • BEHAVIORAL Cognitive Training
  • BEHAVIORAL Computerized Cognitive Stimulation

Study Locations (7)

Florida

  • University of Florida — Gainesville
  • University of Florida — Jacksonville
  • University of North Florida — Jacksonville
  • The Roskamp Institute — Sarasota
  • University of South Florida — Tampa

North Carolina

  • Duke Health — Durham

South Carolina

  • Clemson University Institute for Engaged Aging — Seneca

Trial Details

FieldValue
Enrollment Target 7,600 participants
Start Date 2019-02-19
Est. Completion 2026-01-31
Phase Phase 3

Sponsor

University of South Florida

144 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT03848312

The ClinicalTrials.gov registry entry for NCT03848312 describes a study currently listed as recruiting. It is categorized as Phase 3, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 7,600 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is University of South Florida, which has 144 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 2 conditions, with Age-related Cognitive Decline appearing as the primary indexed condition, and to 2 interventions — of which Cognitive Training is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT03848312 reports 7 study locations spanning 3 distinct geographic areas — top geographies include Florida, North Carolina, South Carolina. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT03848312 about?

NCT03848312 is a clinical study titled "Preventing Alzheimer's With Cognitive Training". Dementia is the most expensive medical condition in the US and increases in prevalence with age. More than 5 million Americans have Alzheimer's disease, the most common form of dementia. Mild cognitive impairment is a transitional stage between normal cognitive aging and Alzheimer's disease or anoth...

What is the current status of trial NCT03848312?

This trial is currently recruiting. It is a Phase 3 study. The enrollment target is 7,600 participants. The study started on 2019-02-19. Estimated completion is 2026-01-31.

What conditions does trial NCT03848312 study?

This clinical trial studies the following conditions: Age-related Cognitive Decline, Alzheimer's Disease and Related Dementias. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT03848312?

The interventions under investigation include: Cognitive Training (BEHAVIORAL), Computerized Cognitive Stimulation (BEHAVIORAL). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT03848312?

This trial is sponsored by University of South Florida, which has 144 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT03848312 being conducted?

This trial has 7 study locations across Florida, North Carolina, South Carolina. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial