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NCT07225270 · ClinicalTrials.gov registry record · Phase 3
Study to Assess the Efficacy and Safety of Rina-S Plus Standard of Care Compared to Standard of Care for Maintenance Treatment of Participants With Recurrent Platinum-sensitive Ovarian Cancer After Second-line (2L) Platinum-based Doublet Chemotherapy
A Phase 3 study of Ovarian Cancer and Platinum-sensitive Ovarian Cancer, sponsored by Genmab.
- Recruiting
- Registry status
- Phase 3
- Development phase
- 528
- Enrollment target
- 2
- Study locations
NCT07225270 is a Phase 3 study of Ovarian Cancer and Platinum-sensitive Ovarian Cancer that is actively recruiting participants, run by Genmab. The registered enrollment target is 528 participants, below the 727-participant average among 322 other Ovarian Cancer trials with a reported enrollment target (27% lower). The trial reports 2 study locations across 2 states.
The verdict
NCT07225270, a Phase 3 study of Ovarian Cancer and Platinum-sensitive Ovarian Cancer, is actively recruiting participants, sponsored by Genmab.
- RECRUITING
- Registry status
- Phase 3
- Development phase
- 528 participants
- Enrollment target
- 2
- Study locations
Study Summary
This Phase 3 study will be conducted in different countries around the world with up to about 528 participants. The purpose of this study is to evaluate how well Rina-S works against ovarian cancer in combination with available standard of care therapy that is already approved and used for ovarian cancer. Participants will receive either Rina-S monotherapy (by itself), Rina-S plus bevacizumab, bevacizumab (standard of care) by itself, or no treatment (only monitoring, also standard of care). No participants will be given placebo. Participants will participate in 1 of 2 arms. The treatment duration will be different for every participant. If a participant's cancer stays the same or gets better, and there are not any serious problems, participants can keep getting study treatment for as long as the study is open. Participants will be asked to attend 1 to 3 visits at the study clinic for each cycle (duration of cycle is 3 weeks). During visits, there will be various tests (such as blood draws) and procedures (such as recording of heart activity and imaging) to monitor whether the study treatment is safe and effective. The overall study duration (including screening, treatment, and follow-up) for each participant will be different for every participant.
Conditions Studied
Interventions
- DRUG Bevacizumab
- DRUG Rina-S
Study Locations (2)
Florida
- Mt. Sinai Comprehensive Cancer Center - Miami
Osaka
- Osaka Medical and Pharmaceutical University Hospital - Takatsuki
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 528 participants |
| Start Date | 2026-03-16 |
| Est. Completion | 2030-04 |
| Phase | Phase 3 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT07225270
The ClinicalTrials.gov registry entry for NCT07225270 describes a study currently listed as recruiting, categorized as Phase 3. The registered enrollment target is 528 participants, a figure that helps gauge the scale of data the investigators plan to collect, below the 727-participant average among 322 other Ovarian Cancer trials with a reported enrollment target (27% lower). The listed sponsor is Genmab, which has 45 total studies on file at ClinicalTrials.gov.
The record links to 3 conditions, with Ovarian Cancer appearing as the primary indexed condition, and to 2 interventions - of which Bevacizumab is the first listed.
NCT07225270 reports 2 study locations spanning 2 distinct geographic areas - top geographies include Florida, Osaka.
Frequently Asked Questions
What is clinical trial NCT07225270 about?
NCT07225270 is a clinical study titled "Study to Assess the Efficacy and Safety of Rina-S Plus Standard of Care Compared to Standard of Care for Maintenance Treatment of Participants With Recurrent Platinum-sensitive Ovarian Cancer After Second-line (2L) Platinum-based Doublet Chemotherapy". This Phase 3 study will be conducted in different countries around the world with up to about 528 participants. The purpose of this study is to evaluate how well Rina-S works against ovarian cancer in combination with available standard of care therapy that is already approved and used for ovarian ...
What is the current status of trial NCT07225270?
This trial is currently recruiting. It is a Phase 3 study. The enrollment target is 528 participants. The study started on 2026-03-16. Estimated completion is 2030-04.
What conditions does trial NCT07225270 study?
This clinical trial studies the following conditions: Ovarian Cancer, Platinum-sensitive Ovarian Cancer, PSOC.
What interventions are being tested in trial NCT07225270?
The interventions under investigation include: Bevacizumab (DRUG), Rina-S (DRUG).
Who is sponsoring clinical trial NCT07225270?
This trial is sponsored by Genmab, which has 45 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT07225270 being conducted?
This trial has 2 study locations across Florida, Osaka. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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