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RECRUITING Phase 3

Efficacy and Safety of KAI-9531 Administered Once Weekly Compared With Semaglutide and Placebo in Participants Living With Obesity Who Do Not Have Diabetes

NCT07284979 · View on ClinicalTrials.gov ↗

Study Summary

The primary objective of this study is to demonstrate that KAI-9531 subcutaneous (SC) injection once weekly is superior to semaglutide SC once weekly and to placebo SC once weekly on percent change in body weight.

Conditions Studied

Interventions

  • DRUG Placebo
  • DRUG KAI-9531
  • DRUG Semaglutide

Study Locations (20)

Arizona

  • Kailera Clinical Site — Glendale
  • Kailera Clinical Site — Phoenix

California

  • Kailera Clinical Site — Northridge
  • Kailera Clinical Site — Oceanside

Connecticut

  • Kailera Clinical Site — Hamden
  • Kailera Clinical Site — Stamford

Arkansas

  • Kailera Clinical Site — Little Rock

Florida

  • Kailera Clinical Site — Orange City

Georgia

  • Kailera Clinical Site — Albany

Illinois

  • Kailera Clinical Site — Chicago

Kansas

  • Kailera Clinical Site — Newton

Trial Details

FieldValue
Enrollment Target 1,200 participants
Start Date 2025-12-30
Est. Completion 2028-04-17
Phase Phase 3

Sponsor

Kailera

34 total trials

Interested in This Trial?

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT07284979

The ClinicalTrials.gov registry entry for NCT07284979 describes a study currently listed as recruiting. It is categorized as Phase 3, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 1,200 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Kailera, which has 34 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 1 condition, with Obesity appearing as the primary indexed condition, and to 3 interventions — of which Placebo is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT07284979 reports 20 study locations spanning 17 distinct geographic areas — top geographies include Arizona, California, Connecticut. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT07284979 about?

NCT07284979 is a clinical study titled "Efficacy and Safety of KAI-9531 Administered Once Weekly Compared With Semaglutide and Placebo in Participants Living With Obesity Who Do Not Have Diabetes". The primary objective of this study is to demonstrate that KAI-9531 subcutaneous (SC) injection once weekly is superior to semaglutide SC once weekly and to placebo SC once weekly on percent change in body weight.

What is the current status of trial NCT07284979?

This trial is currently recruiting. It is a Phase 3 study. The enrollment target is 1,200 participants. The study started on 2025-12-30. Estimated completion is 2028-04-17.

What conditions does trial NCT07284979 study?

This clinical trial studies the following conditions: Obesity. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT07284979?

The interventions under investigation include: Placebo (DRUG), KAI-9531 (DRUG), Semaglutide (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT07284979?

This trial is sponsored by Kailera, which has 34 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT07284979 being conducted?

This trial has 20 study locations across Arizona, Arkansas, California, Connecticut, Florida. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial