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NCT06656819 · ClinicalTrials.gov registry record
The Modulatory Effect of Female Sex Hormones on Spinal Neuroplasticity
A clinical trial of Healthy, sponsored by University of Texas Southwestern Medical Center.
- Recruiting
- Registry status
- 50
- Enrollment target
- 1
- Study location
NCT06656819: Recruiting study of Healthy, sponsored by University of Texas Southwestern Medical Center.
NCT06656819 is a study of Healthy that is actively recruiting participants, run by University of Texas Southwestern Medical Center. The registered enrollment target is 50 participants, below the 647-participant average among 1,090 other Healthy trials with a reported enrollment target (92% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT06656819, a study of Healthy, is actively recruiting participants, sponsored by University of Texas Southwestern Medical Center.
- RECRUITING
- Registry status
- 50 participants
- Enrollment target
- 1
- Study location
Study Summary
The goal of this project is to test our central hypothesis that the spinal cord neuroplasticity in females will be modulated by the level of estradiol concentration. under aim 1 we will determine the influence of estradiol fluctuations on spinal circuit excitability post afferent (sensory) mediated subthreshold motor priming in young healthy females and males. We will use an established repetitive peripheral nerve electrical stimulation with a stimulation intensity below the motor threshold to prime the spinal motor circuits. under aim 2 we seek to characterize the input output property of spinal circuit excitability after descending drive (motor) mediated priming in young healthy male participants. in aim 3 we will examine the influence of estradiol fluctuations on descending drive mediated motor priming in young healthy females.
Primary Outcome
Change in Spinal circuit excitability will be assessed by measuring Hoffmann reflex/ M wave ratio of the soleus muscle. Higher scores indicate poorer outcome.
Conditions Studied
Interventions
- DEVICE Magstim Rapid2
Study Locations (1)
Texas
- University of Texas Southwestern Medical Center - Dallas
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 50 participants |
| Start Date | 2020-07-01 |
| Est. Completion | 2025-12-31 |
What NCT06656819 shows while recruiting
NCT06656819 is an observational study that tracks outcomes without assigning an intervention. The registry caps enrollment at 50 participants, a relatively small participant target, below the 647-participant average among 1,090 other Healthy trials with a reported enrollment target (92% lower).
The record links to 1 condition, with Healthy appearing as the primary indexed condition, and to 1 intervention - of which Magstim Rapid2 is the first listed.
NCT06656819 reports a single indexed study location in Texas.
Frequently Asked Questions
What is clinical trial NCT06656819 about?
NCT06656819 is a clinical study titled "The Modulatory Effect of Female Sex Hormones on Spinal Neuroplasticity". The goal of this project is to test our central hypothesis that the spinal cord neuroplasticity in females will be modulated by the level of estradiol concentration. under aim 1 we will determine the influence of estradiol fluctuations on spinal circuit excitability post afferent (sensory) mediated ...
What is the current status of trial NCT06656819?
This trial is currently recruiting. The enrollment target is 50 participants. The study started on 2020-07-01. Estimated completion is 2025-12-31.
What conditions does trial NCT06656819 study?
This clinical trial studies the following conditions: Healthy.
What interventions are being tested in trial NCT06656819?
The interventions under investigation include: Magstim Rapid2 (DEVICE).
Who is sponsoring clinical trial NCT06656819?
This trial is sponsored by University of Texas Southwestern Medical Center, which has 837 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06656819 being conducted?
This trial has 1 study location across Texas. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Healthy
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT06656819's enrollment target sits among peer trials
50 448th of 1090 higher than 618 of 1,090 other Healthy trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Healthy trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
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