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A Study of Venoarterial ECMO vs Off-Pump Bilateral Orthotopic Lung Transplantation
NCT05547698 · View on ClinicalTrials.gov ↗
Study Summary
The purpose of this research study is to compare the technique of performing bilateral lung transplantation off-pump vs venoarterial ECMO (VA ECMO). The goal of the trial is to determine which technique has lower rates of primary graft dysfunction.
Conditions Studied
Interventions
- PROCEDURE Off-pump lung transplantation
- PROCEDURE Venoarterial ECMO lung transplantation
Study Locations (5)
Pennsylvania
- University of Pennsylvania — Philadelphia
- Temple University Hospital — Philadelphia
Kentucky
- University Of Louisville — Louisville
Minnesota
- Mayo Clinic Rochester — Rochester
Texas
- Baylor College of Medicine — Houston
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 228 participants |
| Start Date | 2022-09-17 |
| Est. Completion | 2027-09 |
| Phase | NA |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT05547698
The ClinicalTrials.gov registry entry for NCT05547698 describes a study currently listed as recruiting. It is categorized as NA, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 228 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Mayo Clinic, which has 3,246 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.
The record links to 1 condition, with Lung Transplant appearing as the primary indexed condition, and to 2 interventions — of which Off-pump lung transplantation is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.
Geographic footprint matters for practical reasons: NCT05547698 reports 5 study locations spanning 4 distinct geographic areas — top geographies include Pennsylvania, Kentucky, Minnesota. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.
Frequently Asked Questions
What is clinical trial NCT05547698 about?
NCT05547698 is a clinical study titled "A Study of Venoarterial ECMO vs Off-Pump Bilateral Orthotopic Lung Transplantation". The purpose of this research study is to compare the technique of performing bilateral lung transplantation off-pump vs venoarterial ECMO (VA ECMO). The goal of the trial is to determine which technique has lower rates of primary graft dysfunction.
What is the current status of trial NCT05547698?
This trial is currently recruiting. It is a NA study. The enrollment target is 228 participants. The study started on 2022-09-17. Estimated completion is 2027-09.
What conditions does trial NCT05547698 study?
This clinical trial studies the following conditions: Lung Transplant. These conditions were identified from the trial registry and reflect the primary focus areas of the research.
What interventions are being tested in trial NCT05547698?
The interventions under investigation include: Off-pump lung transplantation (PROCEDURE), Venoarterial ECMO lung transplantation (PROCEDURE). Each intervention is being evaluated for safety and efficacy as part of this clinical study.
Who is sponsoring clinical trial NCT05547698?
This trial is sponsored by Mayo Clinic, which has 3,246 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.
Where is trial NCT05547698 being conducted?
This trial has 5 study locations across Kentucky, Minnesota, Pennsylvania, Texas. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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