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NCT06290713 · ClinicalTrials.gov registry record · Phase 2
Vasodilator and Exercise Study for DMD (VASO-REx)
A Phase 2 study of Exercise and Duchenne Muscular Dystrophy, sponsored by University of Florida.
- Recruiting
- Registry status
- Phase 2
- Development phase
- 50
- Enrollment target
- 1
- Study location
NCT06290713: Recruiting Phase 2 study of Exercise and Duchenne Muscular Dystrophy, sponsored by University of Florida.
NCT06290713 is a Phase 2 study of Exercise and Duchenne Muscular Dystrophy that is actively recruiting participants, run by University of Florida. The registered enrollment target is 50 participants, below the 8,910-participant average among 57 other Exercise trials with a reported enrollment target (99% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT06290713, a Phase 2 study of Exercise and Duchenne Muscular Dystrophy, is actively recruiting participants, sponsored by University of Florida.
- RECRUITING
- Registry status
- Phase 2
- Development phase
- 50 participants
- Enrollment target
- 1
- Study location
Study Summary
Examining two strategies as potential adjuvant therapies for Duchenne muscular dystrophy (DMD); aerobic exercise training (to induce adaptations in skeletal muscle and improve cardiovascular health) and tadalafil, an FDA-approved vasodilator (to optimize blood flow and muscle perfusion which is impaired and often overlooked in DMD). Target: improved muscle function, vascular health, and DMD treatment.
Primary Outcome
Responsiveness will be determined by an increase in post-contractile muscle oxygenation using MRI-Blood Oxygen Level Dependent (BOLD) responses after dosing compared to before. Study participants demonstrating an increase (\>50%) in post-contractile BOLD after tadalafil will be enrolled into Aim 2 of this study.
Conditions Studied
Interventions
- DRUG Placebo
- OTHER Exercise Training
- DRUG Tadalafil
Study Locations (1)
Florida
- University of Florida Clinical and Translational Research Building - Gainesville
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 50 participants |
| Start Date | 2024-06-05 |
| Est. Completion | 2026-11 |
| Phase | Phase 2 |
What NCT06290713 shows while recruiting
NCT06290713 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 50 participants, a relatively small participant target, below the 8,910-participant average among 57 other Exercise trials with a reported enrollment target (99% lower).
The record links to 7 conditions, with Exercise appearing as the primary indexed condition, and to 3 interventions - of which Placebo is the first listed.
NCT06290713 reports a single indexed study location in Florida.
Frequently Asked Questions
What is clinical trial NCT06290713 about?
NCT06290713 is a clinical study titled "Vasodilator and Exercise Study for DMD (VASO-REx)". Examining two strategies as potential adjuvant therapies for Duchenne muscular dystrophy (DMD); aerobic exercise training (to induce adaptations in skeletal muscle and improve cardiovascular health) and tadalafil, an FDA-approved vasodilator (to optimize blood flow and muscle perfusion which is impa...
What is the current status of trial NCT06290713?
This trial is currently recruiting. It is a Phase 2 study. The enrollment target is 50 participants. The study started on 2024-06-05. Estimated completion is 2026-11.
What conditions does trial NCT06290713 study?
This clinical trial studies the following conditions: Exercise, Duchenne Muscular Dystrophy, Muscular Dystrophy, Vasodilation, DMD.
What interventions are being tested in trial NCT06290713?
The interventions under investigation include: Placebo (DRUG), Exercise Training (OTHER), Tadalafil (DRUG).
Who is sponsoring clinical trial NCT06290713?
This trial is sponsored by University of Florida, which has 1,106 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06290713 being conducted?
This trial has 1 study location across Florida. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Exercise
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT06290713's enrollment target sits among peer trials
50 29th of 57 higher than 26 of 57 other Exercise trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Exercise trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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