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NCT06104592 · ClinicalTrials.gov registry record · Phase 2
Single-Arm Comprehensive Ablative Bridging Irradiation I Prior to CD19 CAR-T In High-Risk R/R LBCL
A Phase 2 study of Large B-cell Lymphoma and Relapsed Non-Hodgkin Lymphoma, sponsored by H. Lee Moffitt Cancer Center and Research Institute.
- Recruiting
- Registry status
- Phase 2
- Development phase
- 27
- Enrollment target
- 1
- Study location
NCT06104592 is a Phase 2 study of Large B-cell Lymphoma and Relapsed Non-Hodgkin Lymphoma that is actively recruiting participants, run by H. Lee Moffitt Cancer Center and Research Institute. The registered enrollment target is 27 participants, below the 158-participant average among 28 other Large B-cell Lymphoma trials with a reported enrollment target (83% lower). The trial reports 1 study location across 1 state.
The verdict
NCT06104592, a Phase 2 study of Large B-cell Lymphoma and Relapsed Non-Hodgkin Lymphoma, is actively recruiting participants, sponsored by H. Lee Moffitt Cancer Center and Research Institute.
- RECRUITING
- Registry status
- Phase 2
- Development phase
- 27 participants
- Enrollment target
- 1
- Study location
Study Summary
This is a phase 2, single-arm, open-label study to evaluate the safety and efficacy of comprehensive bridging radiation therapy prior to CD19 CAR T-cell therapy for large B-cell lymphoma patients with bulky disease, defined as any lesion ≥5 cm.
Conditions Studied
Interventions
- BIOLOGICAL Chimeric Antigen Receptor T-Cell Therapy
- RADIATION Comprehensive Ablative Bridging Irradiation (CABI)
Study Locations (1)
Florida
- Moffitt Cancer Center - Tampa
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 27 participants |
| Start Date | 2023-11-08 |
| Est. Completion | 2026-12 |
| Phase | Phase 2 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT06104592
The ClinicalTrials.gov registry entry for NCT06104592 describes a study currently listed as recruiting, categorized as Phase 2. The registered enrollment target is 27 participants, a figure that helps gauge the scale of data the investigators plan to collect, below the 158-participant average among 28 other Large B-cell Lymphoma trials with a reported enrollment target (83% lower). The listed sponsor is H. Lee Moffitt Cancer Center and Research Institute, which has 502 total studies on file at ClinicalTrials.gov.
The record links to 2 conditions, with Large B-cell Lymphoma appearing as the primary indexed condition, and to 2 interventions - of which Chimeric Antigen Receptor T-Cell Therapy is the first listed.
NCT06104592 reports 1 study location spanning 1 distinct geographic area - top geographies include Florida.
Frequently Asked Questions
What is clinical trial NCT06104592 about?
NCT06104592 is a clinical study titled "Single-Arm Comprehensive Ablative Bridging Irradiation I Prior to CD19 CAR-T In High-Risk R/R LBCL". This is a phase 2, single-arm, open-label study to evaluate the safety and efficacy of comprehensive bridging radiation therapy prior to CD19 CAR T-cell therapy for large B-cell lymphoma patients with bulky disease, defined as any lesion ≥5 cm.
What is the current status of trial NCT06104592?
This trial is currently recruiting. It is a Phase 2 study. The enrollment target is 27 participants. The study started on 2023-11-08. Estimated completion is 2026-12.
What conditions does trial NCT06104592 study?
This clinical trial studies the following conditions: Large B-cell Lymphoma, Relapsed Non-Hodgkin Lymphoma.
What interventions are being tested in trial NCT06104592?
The interventions under investigation include: Chimeric Antigen Receptor T-Cell Therapy (BIOLOGICAL), Comprehensive Ablative Bridging Irradiation (CABI) (RADIATION).
Who is sponsoring clinical trial NCT06104592?
This trial is sponsored by H. Lee Moffitt Cancer Center and Research Institute, which has 502 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06104592 being conducted?
This trial has 1 study location across Florida. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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Related
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page mirrors this trial's own ClinicalTrials.gov registry record, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.