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RECRUITING Phase 2

Optune Delivered Electric Field Therapy and Bevacizumab in Treating Patients With Recurrent or Progressive Grade 2 or 3 Meningioma

NCT02847559 · View on ClinicalTrials.gov ↗

Study Summary

The purpose of this research study is to determine the effects bevacizumab (the study drug) combined with Optune (the study device) tumor treatment field therapy has on meningiomas. Bevacizumab is considered investigational because the US Food and Drug Administration (FDA) has not approved its use for the treatment of meningiomas. The study drug is a medication that blocks the growth of new blood vessels. It is thought that the study drug may interfere with the growth of new blood vessels and therefore might stop tumor growth, and possibly shrink the tumor by keeping it from receiving nutrients and oxygen supplied by the blood vessels. Optune is also considered investigational because the US FDA has not approved its use for the treatment of meningiomas. Optune is a device that the patient will wear and use for at least 18 hours of each day. It delivers alternating electrical current to the patient's brain tumor and by doing so interrupts a process called mitosis. Mitosis needs to occur in order for cell division to occur and allows tumors to grow. By slowing this process, we hypothesize that meningioma growth may also be slowed.

Interventions

  • BIOLOGICAL Bevacizumab
  • PROCEDURE Quality-of-Life Assessment
  • PROCEDURE Electric Field Therapy
  • DEVICE NovoTTF-200A Device

Study Locations (8)

Illinois

  • Northwestern University — Chicago
  • Northwestern University- Lake Forest Hospital — Lake Forest
  • Northwestern Medicine/ Cadence Health - CDH — Winfield

California

  • John Wayne Cancer Center at Providence St. John's Health Center — Santa Monica

Florida

  • Miami Cancer Institute — Miami

Georgia

  • Piedmont Healthcare — Atlanta

North Carolina

  • Vidant Medical Center, East Caroling University — Greenville

Pennsylvania

  • University of Pennsylvania — Philadelphia

Trial Details

FieldValue
Enrollment Target 27 participants
Start Date 2016-08-01
Est. Completion 2026-12
Phase Phase 2

Sponsor

Northwestern University

1,033 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT02847559

The ClinicalTrials.gov registry entry for NCT02847559 describes a study currently listed as recruiting. It is categorized as Phase 2, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 27 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Northwestern University, which has 1,033 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 6 conditions, with Recurrent Meningioma appearing as the primary indexed condition, and to 4 interventions — of which Bevacizumab is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT02847559 reports 8 study locations spanning 6 distinct geographic areas — top geographies include Illinois, California, Florida. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT02847559 about?

NCT02847559 is a clinical study titled "Optune Delivered Electric Field Therapy and Bevacizumab in Treating Patients With Recurrent or Progressive Grade 2 or 3 Meningioma". The purpose of this research study is to determine the effects bevacizumab (the study drug) combined with Optune (the study device) tumor treatment field therapy has on meningiomas. Bevacizumab is considered investigational because the US Food and Drug Administration (FDA) has not approved its use f...

What is the current status of trial NCT02847559?

This trial is currently recruiting. It is a Phase 2 study. The enrollment target is 27 participants. The study started on 2016-08-01. Estimated completion is 2026-12.

What conditions does trial NCT02847559 study?

This clinical trial studies the following conditions: Recurrent Meningioma, Grade III Meningioma, Grade II Meningioma, Anaplastic (Malignant) Meningioma, Atypical Meningioma. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT02847559?

The interventions under investigation include: Bevacizumab (BIOLOGICAL), Quality-of-Life Assessment (PROCEDURE), Electric Field Therapy (PROCEDURE), NovoTTF-200A Device (DEVICE). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT02847559?

This trial is sponsored by Northwestern University, which has 1,033 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT02847559 being conducted?

This trial has 8 study locations across California, Florida, Georgia, Illinois, North Carolina. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial