Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.
NCT05891119 · ClinicalTrials.gov registry record · Early Phase 1
Study to Investigate the Effect of Rocatinlimab (AMG 451) on the Pharmacokinetics of Multiple Cytochrome P450 (CYP450) Substrates in Participants With Moderate to Severe Atopic Dermatitis
A Early Phase 1 study of Atopic Dermatitis, sponsored by Amgen.
- Completed
- Registry status
- Early Phase 1
- Development phase
- 21
- Enrollment target
- 7
- Study locations
NCT05891119 is a Early Phase 1 study of Atopic Dermatitis that has completed, run by Amgen. The registered enrollment target is 21 participants, below the 609-participant average among 150 other Atopic Dermatitis trials with a reported enrollment target (97% lower). The trial reports 7 study locations across 6 states.
The verdict
NCT05891119, a Early Phase 1 study of Atopic Dermatitis, has completed, sponsored by Amgen.
- COMPLETED
- Registry status
- Early Phase 1
- Development phase
- 21 participants
- Enrollment target
- 7
- Study locations
Study Summary
The primary objective of the study is to evaluate the pharmacokinetics (PK) of multiple cytochrome P450 (CYP450) substrates alone and in combination with rocatinlimab in participants with moderate to severe atopic dermatitis (AD).
Conditions Studied
Interventions
- DRUG Midazolam
- DRUG Warfarin
- DRUG Metoprolol
- DIETARY_SUPPLEMENT Vitamin K
- DIETARY_SUPPLEMENT Caffeine
Study Locations (7)
Florida
- Accel Research Sites (ACR) - DeLand
- Direct Helpers Research Center (DHRC) - Hialeah
California
- Velocity Clinical Research, North Hollywood - North Hollywood
Minnesota
- Axis Clinicals, LCC - Dilworth
Pennsylvania
- DermDox Dermatology Centers, PC - Camp Hill - Camp Hill
South Carolina
- Velocity Clinical Research -Spartanburg - Spartanburg
Tennessee
- DermDox Dermatology Centers, PC - Sugarloaf - Nashville
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 21 participants |
| Start Date | 2023-06-03 |
| Est. Completion | 2025-02-12 |
| Phase | Early Phase 1 |
Interested in This Trial?
Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT05891119
The ClinicalTrials.gov registry entry for NCT05891119 describes a study currently listed as completed, categorized as Early Phase 1. The registered enrollment target is 21 participants, a figure that helps gauge the scale of data the investigators plan to collect, below the 609-participant average among 150 other Atopic Dermatitis trials with a reported enrollment target (97% lower). The listed sponsor is Amgen, which has 558 total studies on file at ClinicalTrials.gov.
The record links to 1 condition, with Atopic Dermatitis appearing as the primary indexed condition, and to 5 interventions - of which Midazolam is the first listed.
NCT05891119 reports 7 study locations spanning 6 distinct geographic areas - top geographies include Florida, California, Minnesota.
Frequently Asked Questions
What is clinical trial NCT05891119 about?
NCT05891119 is a clinical study titled "Study to Investigate the Effect of Rocatinlimab (AMG 451) on the Pharmacokinetics of Multiple Cytochrome P450 (CYP450) Substrates in Participants With Moderate to Severe Atopic Dermatitis". The primary objective of the study is to evaluate the pharmacokinetics (PK) of multiple cytochrome P450 (CYP450) substrates alone and in combination with rocatinlimab in participants with moderate to severe atopic dermatitis (AD).
What is the current status of trial NCT05891119?
This trial is currently completed. It is a Early Phase 1 study. The enrollment target is 21 participants. The study started on 2023-06-03. Estimated completion is 2025-02-12.
What conditions does trial NCT05891119 study?
This clinical trial studies the following conditions: Atopic Dermatitis.
What interventions are being tested in trial NCT05891119?
The interventions under investigation include: Midazolam (DRUG), Warfarin (DRUG), Metoprolol (DRUG), Vitamin K (DIETARY_SUPPLEMENT), Caffeine (DIETARY_SUPPLEMENT).
Who is sponsoring clinical trial NCT05891119?
This trial is sponsored by Amgen, which has 558 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT05891119 being conducted?
This trial has 7 study locations across California, Florida, Minnesota, Pennsylvania, South Carolina. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Atopic Dermatitis
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
-
IL-4 and Insulin Resistance for Treatment of Patients With Atopic Dermatitis
COMPLETED · Early Phase 1
-
Registry for Systemic Eczema Treatments
RECRUITING
-
An Observational Retrospective Cohort Study Being Conducted in Women With Atopic Dermatitis (AD)
RECRUITING
-
An Observational Retrospective Cohort Study Being Conducted in Women With Atopic Dermatitis Exposed to Ruxolitinib Cream Versus Topical Corticosteroids During Pregnancy: A US Claims Database Analysis
RECRUITING
-
A Study to Evaluate the Efficacy and Safety of IMG-007 in Adult Participants With Moderate-to-Severe Atopic Dermatitis
RECRUITING · Phase 2
-
Evaluating the Safety and Tolerability of Baricitinib in Patients With Job Syndrome With Lupus-Like Disease and/or Atopic Dermatitis
RECRUITING · Phase 1
Read our methodology - how this data is sourced, computed, and verified.
Related
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page mirrors this trial's own ClinicalTrials.gov registry record, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.