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NCT05712772 · ClinicalTrials.gov registry record · NA
Neuro-affective Response to Light in Depressed Adolescents and Young Adults
A NA study of Depression in Adolescence and Depression in Adults, sponsored by University of Pittsburgh.
- Recruiting
- Registry status
- NA
- Development phase
- 80
- Enrollment target
- 1
- Study location
NCT05712772: Recruiting NA study of Depression in Adolescence and Depression in Adults, sponsored by University of Pittsburgh.
NCT05712772 is a NA study of Depression in Adolescence and Depression in Adults that is actively recruiting participants, run by University of Pittsburgh. The registered enrollment target is 80 participants, below the 161-participant average among 7 other Depression in Adolescence trials with a reported enrollment target (50% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT05712772, a NA study of Depression in Adolescence and Depression in Adults, is actively recruiting participants, sponsored by University of Pittsburgh.
- RECRUITING
- Registry status
- NA
- Development phase
- 80 participants
- Enrollment target
- 1
- Study location
Study Summary
The goal of this neuroimaging pilot study is to understand developmental differences in the impact of therapeutic wavelength light (blue light) versus a non-therapeutic wavelength (red light) on emotional brain function in depression. The main questions this study aims to answer are: * Does acute exposure to blue light (vs red light) stabilize emotional brain function in depressed individuals? * Are stabilizing effects of blue light (vs red light) stronger for blue light in adolescents than young adults? Participants will complete: * A magnetic resonance imaging brain scan, in which we will examine the effect of blue versus red light on emotional brain function at rest and in response to rewards and losses. * A pupillometry test of sensitivity to blue vs red light * Clinical interviews and surveys * Screening measures for drug and alcohol use, MRI safety, and current pregnancy \[if relevant\] * Home sleep tracking with sleep diary and actigraphy for one week
Primary Outcome
Cerebral blood flow will be assessed using pseudo-continuous arterial spin labeling collected during blue and red light exposures. Regional cerebral blood flow in the amygdala region of interest will be examined.
Conditions Studied
Interventions
- OTHER Blue Light
- OTHER Red Light
Study Locations (1)
Pennsylvania
- Western Psychiatric Hospital - Pittsburgh
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 80 participants |
| Start Date | 2023-06-14 |
| Est. Completion | 2026-07-31 |
| Phase | NA |
What NCT05712772 shows while recruiting
NCT05712772 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 80 participants, a relatively small participant target, below the 161-participant average among 7 other Depression in Adolescence trials with a reported enrollment target (50% lower).
The record links to 2 conditions, with Depression in Adolescence appearing as the primary indexed condition, and to 2 interventions - of which Blue Light is the first listed.
NCT05712772 reports a single indexed study location in Pennsylvania.
Frequently Asked Questions
What is clinical trial NCT05712772 about?
NCT05712772 is a clinical study titled "Neuro-affective Response to Light in Depressed Adolescents and Young Adults". The goal of this neuroimaging pilot study is to understand developmental differences in the impact of therapeutic wavelength light (blue light) versus a non-therapeutic wavelength (red light) on emotional brain function in depression. The main questions this study aims to answer are: * Does acute e...
What is the current status of trial NCT05712772?
This trial is currently recruiting. It is a NA study. The enrollment target is 80 participants. The study started on 2023-06-14. Estimated completion is 2026-07-31.
What conditions does trial NCT05712772 study?
This clinical trial studies the following conditions: Depression in Adolescence, Depression in Adults.
What interventions are being tested in trial NCT05712772?
The interventions under investigation include: Blue Light (OTHER), Red Light (OTHER).
Who is sponsoring clinical trial NCT05712772?
This trial is sponsored by University of Pittsburgh, which has 1,238 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT05712772 being conducted?
This trial has 1 study location across Pennsylvania. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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