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NCT05617495 · ClinicalTrials.gov registry record · NA
Mindfulness-Based fMRI Neurofeedback for Depression
A NA study of Depression in Adolescence and Rumination, sponsored by Columbia University.
- Recruiting
- Registry status
- NA
- Development phase
- 90
- Enrollment target
- 2
- Study locations
NCT05617495: Recruiting NA study of Depression in Adolescence and Rumination, sponsored by Columbia University.
NCT05617495 is a NA study of Depression in Adolescence and Rumination that is actively recruiting participants, run by Columbia University. The registered enrollment target is 90 participants, below the 160-participant average among 7 other Depression in Adolescence trials with a reported enrollment target (44% lower). The trial reports 2 study locations across 2 states. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT05617495, a NA study of Depression in Adolescence and Rumination, is actively recruiting participants, sponsored by Columbia University.
- RECRUITING
- Registry status
- NA
- Development phase
- 90 participants
- Enrollment target
- 2
- Study locations
Study Summary
In the United States, adolescents experience alarmingly high rates of major depression, and gold-standard treatments are only effective for approximately half of patients. Rumination may be a promising treatment target, as it is well-characterized at the neural level and contributes to depression onset, maintenance, and recurrence as well as predicts treatment non-response. Accordingly, the proposed research will investigate whether an innovative mindfulness-based real-time functional magnetic resonance imaging (fMRI) neurofeedback intervention successfully elicits change in the brain circuit underlying rumination to improve clinical outcomes among depressed adolescents.
Primary Outcome
DMN change will be assessed via fMRI from before mbNF.
Conditions Studied
Interventions
- OTHER Mindfulness + fMRI Neurofeedback
Study Locations (2)
Massachusetts
- Northeastern University - Boston
New York
- Columbia University Irving Medical Center - New York
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 90 participants |
| Start Date | 2024-04-10 |
| Est. Completion | 2026-06-30 |
| Phase | NA |
What NCT05617495 shows while recruiting
NCT05617495 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 90 participants, a relatively small participant target, below the 160-participant average among 7 other Depression in Adolescence trials with a reported enrollment target (44% lower).
The record links to 2 conditions, with Depression in Adolescence appearing as the primary indexed condition, and to 1 intervention - of which Mindfulness + fMRI Neurofeedback is the first listed.
NCT05617495 reports a single indexed study location in Massachusetts, New York.
Frequently Asked Questions
What is clinical trial NCT05617495 about?
NCT05617495 is a clinical study titled "Mindfulness-Based fMRI Neurofeedback for Depression". In the United States, adolescents experience alarmingly high rates of major depression, and gold-standard treatments are only effective for approximately half of patients. Rumination may be a promising treatment target, as it is well-characterized at the neural level and contributes to depression on...
What is the current status of trial NCT05617495?
This trial is currently recruiting. It is a NA study. The enrollment target is 90 participants. The study started on 2024-04-10. Estimated completion is 2026-06-30.
What conditions does trial NCT05617495 study?
This clinical trial studies the following conditions: Depression in Adolescence, Rumination.
What interventions are being tested in trial NCT05617495?
The interventions under investigation include: Mindfulness + fMRI Neurofeedback (OTHER).
Who is sponsoring clinical trial NCT05617495?
This trial is sponsored by Columbia University, which has 958 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT05617495 being conducted?
This trial has 2 study locations across Massachusetts, New York. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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