Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.

COMPLETED Phase 3

A Study of Insulin Efsitora Alfa (LY3209590) Compared to Glargine in Adult Participants With Type 2 Diabetes Who Are Starting Basal Insulin for the First Time (QWINT-1)

NCT05662332 · View on ClinicalTrials.gov ↗

Study Summary

The main purpose of this study is to determine the efficacy and safety of insulin efsitora alfa (LY3209590) administered weekly using a fixed dose escalation compared to insulin glargine in adults with type 2 diabetes (T2D) who are starting basal insulin therapy for the first time.

Conditions Studied

Interventions

  • DRUG Insulin Glargine
  • DRUG Insulin Efsitora Alfa

Study Locations (20)

California

  • AMCR Institute — Escondido
  • Velocity Clinical Research, Gardena — Gardena
  • National Research Institute - Huntington Park — Huntington Park
  • National Research Institute - Wilshire — Los Angeles
  • Diabetes Associates Medical Group — Orange
  • Encompass Clinical Research — Spring Valley
  • Millennium Clinical Trials — Thousand Oaks
  • University Clinical Investigators, Inc. — Tustin
  • Diablo Clinical Research, Inc. — Walnut Creek

Florida

  • Clinical Research of West Florida, Inc. (Clearwater) — Clearwater
  • Suncoast Research Group — Miami
  • Clinical Research of West Florida — Tampa

Alabama

  • Cahaba Research — Birmingham
  • Syed Research Consultants Llc — Sheffield

Colorado

  • University of Colorado Anschutz Medical Campus — Aurora

Connecticut

  • Chase Medical Research, LLC — Waterbury

Georgia

  • Center for Advanced Research & Education — Gainesville

Hawaii

  • Pacific Diabetes & Endocrine Center — Honolulu

Illinois

  • Central Illinois Diabetes and Clinical Research a Division of Prairie Education and Research Cooperative — Springfield

Trial Details

FieldValue
Enrollment Target 795 participants
Start Date 2023-01-14
Est. Completion 2024-07-19
Phase Phase 3

Sponsor

Eli Lilly and Company

704 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT05662332

The ClinicalTrials.gov registry entry for NCT05662332 describes a study currently listed as completed. It is categorized as Phase 3, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 795 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Eli Lilly and Company, which has 704 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 2 conditions, with Type 2 Diabetes appearing as the primary indexed condition, and to 2 interventions — of which Insulin Glargine is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT05662332 reports 20 study locations spanning 9 distinct geographic areas — top geographies include California, Florida, Alabama. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT05662332 about?

NCT05662332 is a clinical study titled "A Study of Insulin Efsitora Alfa (LY3209590) Compared to Glargine in Adult Participants With Type 2 Diabetes Who Are Starting Basal Insulin for the First Time (QWINT-1)". The main purpose of this study is to determine the efficacy and safety of insulin efsitora alfa (LY3209590) administered weekly using a fixed dose escalation compared to insulin glargine in adults with type 2 diabetes (T2D) who are starting basal insulin therapy for the first time.

What is the current status of trial NCT05662332?

This trial is currently completed. It is a Phase 3 study. The enrollment target is 795 participants. The study started on 2023-01-14. Estimated completion is 2024-07-19.

What conditions does trial NCT05662332 study?

This clinical trial studies the following conditions: Type 2 Diabetes, T2D. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT05662332?

The interventions under investigation include: Insulin Glargine (DRUG), Insulin Efsitora Alfa (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT05662332?

This trial is sponsored by Eli Lilly and Company, which has 704 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT05662332 being conducted?

This trial has 20 study locations across Alabama, California, Colorado, Connecticut, Florida. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial