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NCT05523817 · ClinicalTrials.gov registry record · NA
Targeting Specific Brain Networks to Treat Specific Symptoms in Depression
A NA study of Major Depressive Disorder, sponsored by Massachusetts General Hospital.
- Recruiting
- Registry status
- NA
- Development phase
- 80
- Enrollment target
- 1
- Study location
NCT05523817: Recruiting NA study of Major Depressive Disorder, sponsored by Massachusetts General Hospital.
NCT05523817 is a NA study of Major Depressive Disorder that is actively recruiting participants, run by Massachusetts General Hospital. The registered enrollment target is 80 participants, below the 377-participant average among 282 other Major Depressive Disorder trials with a reported enrollment target (79% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT05523817, a NA study of Major Depressive Disorder, is actively recruiting participants, sponsored by Massachusetts General Hospital.
- RECRUITING
- Registry status
- NA
- Development phase
- 80 participants
- Enrollment target
- 1
- Study location
Study Summary
Repetitive transcranial magnetic stimulation (rTMS) is a way of non-invasively stimulating specific brain networks and is an established treatment for Major Depressive Disorder (MDD). This proposal will reveal network mechanisms of the therapeutic effects of rTMS by investigating how stimulating each network specifically changes network connectivity and behavior. This will be done in a highly individualized manner in depressed and healthy patients, leading to more effective and more individualized treatments for depression.
Primary Outcome
Changes in connectivity within and between brain networks
Conditions Studied
Interventions
- DEVICE Intermittent Theta Burst Stimulation (iTBS)
Study Locations (1)
Massachusetts
- Massachusetts General Hospital - Boston
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 80 participants |
| Start Date | 2024-03-12 |
| Est. Completion | 2028-12-31 |
| Phase | NA |
What NCT05523817 shows while recruiting
NCT05523817 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 80 participants, a relatively small participant target, below the 377-participant average among 282 other Major Depressive Disorder trials with a reported enrollment target (79% lower).
The record links to 1 condition, with Major Depressive Disorder appearing as the primary indexed condition, and to 1 intervention - of which Intermittent Theta Burst Stimulation (iTBS) is the first listed.
NCT05523817 reports a single indexed study location in Massachusetts.
Frequently Asked Questions
What is clinical trial NCT05523817 about?
NCT05523817 is a clinical study titled "Targeting Specific Brain Networks to Treat Specific Symptoms in Depression". Repetitive transcranial magnetic stimulation (rTMS) is a way of non-invasively stimulating specific brain networks and is an established treatment for Major Depressive Disorder (MDD). This proposal will reveal network mechanisms of the therapeutic effects of rTMS by investigating how stimulating eac...
What is the current status of trial NCT05523817?
This trial is currently recruiting. It is a NA study. The enrollment target is 80 participants. The study started on 2024-03-12. Estimated completion is 2028-12-31.
What conditions does trial NCT05523817 study?
This clinical trial studies the following conditions: Major Depressive Disorder.
What interventions are being tested in trial NCT05523817?
The interventions under investigation include: Intermittent Theta Burst Stimulation (iTBS) (DEVICE).
Who is sponsoring clinical trial NCT05523817?
This trial is sponsored by Massachusetts General Hospital, which has 2,032 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT05523817 being conducted?
This trial has 1 study location across Massachusetts. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Major Depressive Disorder
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT05523817's enrollment target sits among peer trials
80 143rd of 282 higher than 134 of 282 other Major Depressive Disorder trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Major Depressive Disorder trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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