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NCT05493722 · ClinicalTrials.gov registry record · Early Phase 1
Optimization of Deep Brain Stimulation Parameters in Patients With Medically Refractory Epilepsy
A Early Phase 1 study of Deep Brain Stimulation and Refractory Epilepsy, sponsored by University of Minnesota.
- Recruiting
- Registry status
- Early Phase 1
- Development phase
- 20
- Enrollment target
- 1
- Study location
NCT05493722: Recruiting Early Phase 1 study of Deep Brain Stimulation and Refractory Epilepsy, sponsored by University of Minnesota.
NCT05493722 is a Early Phase 1 study of Deep Brain Stimulation and Refractory Epilepsy that is actively recruiting participants, run by University of Minnesota. The registered enrollment target is 20 participants, below the 815-participant average among 15 other Deep Brain Stimulation trials with a reported enrollment target (98% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT05493722, a Early Phase 1 study of Deep Brain Stimulation and Refractory Epilepsy, is actively recruiting participants, sponsored by University of Minnesota.
- RECRUITING
- Registry status
- Early Phase 1
- Development phase
- 20 participants
- Enrollment target
- 1
- Study location
Study Summary
Deep brain stimulation (DBS) is used to treat epilepsy in cases where patients are medically refractory and are not candidates for surgical resection. This therapy has been shown to be effective in seizure reduction, yet very few patients achieve the ultimate goal of seizure freedom. Implantable neural stimulators (INSs) have many parameters that may be adjusted, and could be tuned to achieve very patient specific therapies. This study will develop a platform for stimulation setting optimization based on power spectral density (PSD) measures.
Primary Outcome
Different settings include different combinations of stimulation amplitude, frequency and pulse width. The full spectrum PSD data from all of the in-clinic recordings at all of the unique settings will be combined to look at the resulting difference in broadband power.
Conditions Studied
Interventions
- OTHER PS and OS stimulation order 1
- OTHER PS and OS stimulation order 2
- OTHER PS and OS stimulation order 3
Study Locations (1)
Minnesota
- University of Minnesota - Minneapolis
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 20 participants |
| Start Date | 2023-09-15 |
| Est. Completion | 2030-01-15 |
| Phase | Early Phase 1 |
What NCT05493722 shows while recruiting
NCT05493722 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 20 participants, a relatively small participant target, below the 815-participant average among 15 other Deep Brain Stimulation trials with a reported enrollment target (98% lower).
The record links to 2 conditions, with Deep Brain Stimulation appearing as the primary indexed condition, and to 3 interventions - of which PS and OS stimulation order 1 is the first listed.
NCT05493722 reports a single indexed study location in Minnesota.
Frequently Asked Questions
What is clinical trial NCT05493722 about?
NCT05493722 is a clinical study titled "Optimization of Deep Brain Stimulation Parameters in Patients With Medically Refractory Epilepsy". Deep brain stimulation (DBS) is used to treat epilepsy in cases where patients are medically refractory and are not candidates for surgical resection. This therapy has been shown to be effective in seizure reduction, yet very few patients achieve the ultimate goal of seizure freedom. Implantable neu...
What is the current status of trial NCT05493722?
This trial is currently recruiting. It is a Early Phase 1 study. The enrollment target is 20 participants. The study started on 2023-09-15. Estimated completion is 2030-01-15.
What conditions does trial NCT05493722 study?
This clinical trial studies the following conditions: Deep Brain Stimulation, Refractory Epilepsy.
What interventions are being tested in trial NCT05493722?
The interventions under investigation include: PS and OS stimulation order 1 (OTHER), PS and OS stimulation order 2 (OTHER), PS and OS stimulation order 3 (OTHER).
Who is sponsoring clinical trial NCT05493722?
This trial is sponsored by University of Minnesota, which has 966 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT05493722 being conducted?
This trial has 1 study location across Minnesota. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
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Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT05493722's enrollment target sits among peer trials
20 13th of 15 higher than 3 of 15 other Deep Brain Stimulation trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Deep Brain Stimulation trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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