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Mirvetuximab Soravtansine With Bevacizumab Versus Bevacizumab as Maintenance in Platinum-sensitive Epithelial Ovarian, Fallopian Tube, or Peritoneal Cancer
NCT05445778 · View on ClinicalTrials.gov ↗
Study Summary
GLORIOSA is a Phase 3 multicenter, open label study designed to evaluate the safety and efficacy of mirvetuximab Soravtansine + Bevacizumab as maintenance therapy in participants with platinum-sensitive ovarian, primary peritoneal or fallopian tube cancers with high folate receptor-alpha (FRα) expression.
Conditions Studied
Interventions
- DRUG Bevacizumab
- DRUG Mirvetuximab soravtansine plus Bevacizumab
Study Locations (20)
California
- City of Hope - Orange County Lennar Foundation Cancer Center /ID# 269573 — Irvine
- Moores Cancer Center at UC San Diego /ID# 269564 — La Jolla
- Kaiser Permanente - Los Angeles Medical Center /ID# 269541 — Los Angeles
- University Of California Irvine Medical Center /ID# 269572 — Orange
- Stanford Women'S Cancer Center /ID# 269552 — Palo Alto
- Kaiser Permanente - Riverside Medical Center /ID# 269539 — Riverside
- Kaiser Permanente Zion Medical Center /ID# 269537 — San Diego
- Kaiser Permanente - San Diego Medical Center /ID# 269540 — San Diego
- Kaiser Permanente - San Marcos Medical Offices /ID# 269542 — San Marcos
- Olive View-Ucla Medical Center /ID# 269584 — Sylmar
- John Muir Health - Walnut Creek Medical Center /ID# 269575 — Walnut Creek
Florida
- Broward General Medical Center /ID# 269577 — Fort Lauderdale
- Regional Cancer Center /ID# 269558 — Fort Myers
- Baptist Md Anderson Cancer Center - Jacksonville - Palm Avenue /ID# 269560 — Jacksonville
- Mount Sinai Medical Center /ID# 269582 — Miami
- Sarasota Memorial Hospital /ID# 269526 — Sarasota
Alabama
- Usa Mitchell Cancer Institute /ID# 269661 — Mobile
Arizona
- Honorhealth Virginia G. Piper Cancer Care Network - Biltmore /ID# 269987 — Phoenix
Georgia
- Northside Hospital /ID# 269660 — Atlanta
Illinois
- Rush University Medical Center /ID# 269583 — Chicago
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 520 participants |
| Start Date | 2023-03-15 |
| Est. Completion | 2032-05 |
| Phase | Phase 3 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT05445778
The ClinicalTrials.gov registry entry for NCT05445778 describes a study currently listed as recruiting. It is categorized as Phase 3, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 520 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is AbbVie, which has 603 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.
The record links to 3 conditions, with Ovarian Cancer appearing as the primary indexed condition, and to 2 interventions — of which Bevacizumab is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.
Geographic footprint matters for practical reasons: NCT05445778 reports 20 study locations spanning 6 distinct geographic areas — top geographies include California, Florida, Alabama. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.
Frequently Asked Questions
What is clinical trial NCT05445778 about?
NCT05445778 is a clinical study titled "Mirvetuximab Soravtansine With Bevacizumab Versus Bevacizumab as Maintenance in Platinum-sensitive Epithelial Ovarian, Fallopian Tube, or Peritoneal Cancer". GLORIOSA is a Phase 3 multicenter, open label study designed to evaluate the safety and efficacy of mirvetuximab Soravtansine + Bevacizumab as maintenance therapy in participants with platinum-sensitive ovarian, primary peritoneal or fallopian tube cancers with high folate receptor-alpha (FRα) expre...
What is the current status of trial NCT05445778?
This trial is currently recruiting. It is a Phase 3 study. The enrollment target is 520 participants. The study started on 2023-03-15. Estimated completion is 2032-05.
What conditions does trial NCT05445778 study?
This clinical trial studies the following conditions: Ovarian Cancer, Fallopian Tube Cancer, Peritoneal Cancer. These conditions were identified from the trial registry and reflect the primary focus areas of the research.
What interventions are being tested in trial NCT05445778?
The interventions under investigation include: Bevacizumab (DRUG), Mirvetuximab soravtansine plus Bevacizumab (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.
Who is sponsoring clinical trial NCT05445778?
This trial is sponsored by AbbVie, which has 603 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.
Where is trial NCT05445778 being conducted?
This trial has 20 study locations across Alabama, Arizona, California, Florida, Georgia. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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