Medical Information Only. Consult your healthcare provider before considering clinical trial enrollment.
Lynch Syndrome: early-phase trial registry
9 of 22 indexed Lynch Syndrome trials are currently recruiting, with more weight in Phase 1-2.
Corpus placement: #756 of 28,707 conditions by registered trial count.
22 US clinical trials · 9 currently recruiting · #756 of 28,707 conditions by registered trial count
Lynch Syndrome: 22 US clinical trials tracked, 9 recruiting.
Lynch Syndrome is the subject of 22 registered US clinical trials on ClinicalTrials.gov, 9 of them currently open to new participants. 2 are in Phase 3-4 (later-stage) and 4 in Phase 1-2 (earlier-stage). The most active sponsor is M.D. Anderson Cancer Center, running 4 of these trials.
Enrollment posture brief
Registry condition lynch-syndrome
OPEN 9 | RECR 41% | LATE 2 | EARLY 4 | RANK #756 | SPON 4
Volume-matched condition peers
Nearest open-share peer: Brain Injuries, Traumatic (41% recruiting · 22 trials)
Lynch Syndrome lists 9 open slots (41% of 22 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →
Key findings
What ClinicalTrials.gov does not surface for Lynch Syndrome on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.
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Lynch Syndrome recruits in line with its size-band peers.
9 of 22 indexed trials (40.9%) are open to enrollment, against a 39.7% average across 762 conditions with 20-99 trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.
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One sponsor concentrates Lynch Syndrome research.
M.D. Anderson Cancer Center accounts for 4 of 22 trials (18.2%). 14 distinct sponsors appear on at least one study for this condition label.
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Typical Lynch Syndrome enrolment sits around 337 participants.
Median target enrolment is 337 among the 22 trials that report a genuine target (sentinel values excluded). 6 of those (27.3%) plan for fewer than 100 participants.
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Lynch Syndrome splits between interventional and observational designs.
14 interventional and 8 observational studies make up this index (63.6% interventional). Study type is sponsor-reported on ClinicalTrials.gov.
Open and recent trials
22 total, page 1 of 1
Identifying and Caring for Individuals With Inherited Cancer Syndrome
OHSU Knight Cancer Institute
NCT04494945
The Cancer of the Pancreas Screening-5 CAPS5)Study
Johns Hopkins University
NCT02000089
Lynch Syndrome Integrative Epidemiology and Genetics
University of Colorado, Denver
NCT06582914
Collecting Blood and Stool Samples to Detect Colorectal Cancer or Advanced Neoplasia in Lynch Syndrome Patients
Mayo Clinic
NCT05410977
Prostate Cancer Genetic Risk Evaluation and Screening Study
Massachusetts General Hospital
NCT05129605
Lynch Syndrome X-Talk of Enteral Mucosa With Immune System
San Raffaele University
NCT06708429
A Phase IIa Randomized, Double-Blinded Clinical Trial of Naproxen or Aspirin for Cancer Immune Interception in Lynch Syndrome
M.D. Anderson Cancer Center
NCT05411718
A Study for Imaging the Lower Gastrointestinal Tract Using a Retro-TCE Capsule
Massachusetts General Hospital
NCT07219537
Menstrual Cup for Early Endometrial Cancer Detection in Lynch Syndrome
Jessica D. St. Laurent, MD
NCT07220239
Multi-Organ Screening Recommendations in Patients With Lynch Syndrome
Memorial Sloan Kettering Cancer Center
NCT00582296
Scalable Communication Modalities for Returning Genetic Research Results
Boston University
NCT04407611
Combination Chemotherapy With or Without Atezolizumab in Treating Patients With Stage III Colon Cancer and Deficient DNA Mismatch Repair
National Cancer Institute (NCI)
NCT02912559
Weight Management and Health Behavior Intervention in Lowering Cancer Risk for BRCA Positive and Lynch Syndrome Families
M.D. Anderson Cancer Center
NCT04125914
Energy Balance Interventions in Increasing Physical Activity in Breast Cancer Gene Positive Patients, Lynch Syndrome-Positive Patients, CLL Survivors or High-Risk Family Members
M.D. Anderson Cancer Center
NCT02194387
The Pancreas Interception Center (PIC) for Early Detection, Prevention, and Novel Therapeutics
H. Lee Moffitt Cancer Center and Research Institute
NCT05692596
Feasibility Study: IGNITE-TX (Identifying Individuals for Genetic Testing & Treatment) Intervention
M.D. Anderson Cancer Center
NCT05677048
Testing a Combination of Vaccines for Cancer Prevention in Lynch Syndrome
National Cancer Institute (NCI)
NCT05419011
Pancreatic Cancer Early Detection Program
White Plains Hospital
NCT02206360
Metagenomic Evaluation of the Gut Microbiome in Patients With Lynch Syndrome and Other Hereditary Colonic Polyposis Syndromes
Memorial Sloan Kettering Cancer Center
NCT02371135
Pembrolizumab in Treating Younger Patients With Recurrent, Progressive, or Refractory High-Grade Gliomas, Diffuse Intrinsic Pontine Gliomas, Hypermutated Brain Tumors, Ependymoma or Medulloblastoma
National Cancer Institute (NCI)
NCT02359565
Cancer Preventive Vaccine Nous-209 for Lynch Syndrome Patients
National Cancer Institute (NCI)
NCT05078866
Trial to Compare eConsent With Standard Consent Among Prospective Biobank Participants
Geisinger Clinic
NCT04131062
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 2 |
| Phase 2 | 2 |
| Phase 3 | 2 |
Top Sponsors
Named interventions
Most-linked intervention names on Lynch Syndrome records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.
US sites by state
Facility locations filed on Lynch Syndrome trials. A trial with sites in several states counts in each.
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Related
What to do with this Lynch Syndrome page
22 registered trials, 9 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.
- 9 Lynch Syndrome trials are currently recruiting, check eligibility criteria before contacting a site. Browse recruiting trials
- M.D. Anderson Cancer Center sponsors the most Lynch Syndrome trials on record, review their full trial history before evaluating a specific study. See M.D. Anderson Cancer Center's trials
- Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide
Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This Lynch Syndrome condition card totals 22 registered trials; most-linked intervention Biospecimen Collection; top US site state Texas. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.