Medical Information Only. Consult your healthcare provider before considering clinical trial enrollment.
OSA clinical trials
Every US clinical trial registered for OSA — phase mix, recruiting status, and the sponsors running them, straight from the NIH ClinicalTrials.gov registry.
15 US clinical trials · 6 currently recruiting
The research picture
OSA has 15 registered US clinical trials, 6 of them open to new participants right now — about 40% of the total.
- 6
- recruiting participants now
- 40%
- of trials open to enrollment
- 3
- in Phase 3–4 (later-stage)
- 2
- top sponsor: Brigham and Women's Hospital
Counts reflect the public ClinicalTrials.gov registry as last mirrored by PlainTrial. Status and phase are reported by each study's sponsor. This is reference information, not medical advice.
Active & Recent Trials
Is Obstructive Sleep Apnea Important in the Development of Alzheimer's Disease?
University of California, San Diego
NCT05094271
Diagnosing Obstructive Sleep Apnea Using Electromyography of the Muscles of the Mouth
University of California, San Diego
NCT06944782
Mandibular Advancement Device and Changes in Nocturia
Fernanda Yanez Regonesi
NCT05562388
Acetazolamide as a Means to Mitigate Falling Ventilatory Drive and Drive-dependent OSA
Brigham and Women's Hospital
NCT06091085
Reversible Effect of Falling Ventilatory Drive in Drive-dependent OSA
Brigham and Women's Hospital
NCT06091098
The Effect of Interval Exercise on Functional Outcomes in Veterans With COPD and OSA
VA Office of Research and Development
NCT05254431
A Master Protocol for Orforglipron in Participants With Obstructive Sleep Apnea and Obesity or Overweight
Eli Lilly and Company
NCT06649045
Treating Obstructive Sleep Apnea Using Targeted Hypoglossal Neurostimulation
LivaNova
NCT04950894
Parallel Arm Trial of AD109 and Placebo With Patients With OSA (LunAIRo)
Apnimed
NCT05811247
Randomized Study of Provent Versus Sham Device to Treat Obstructive Sleep Apnea
Ventus Medical
NCT00772044
Impact of OSA on Outcomes in Acute Coronary Syndrome
MetroHealth Medical Center
NCT03793582
Novel by Upper Airway Respiratory Muscle Training to Treat OSA in Chronic SCI
VA Office of Research and Development
NCT03664765
Sham CPAP vs. Straight CPAP for Chronic Cough
Krishna M. Sundar
NCT03172130
Early Feasibility Study of Transcutaneous Upper Airway Stimulation in Obstructive Sleep Apnea
Somnial
NCT05881512
Comparison of Standing Versus Supine 3D Cone Beam Computed Tomography in Patient With Obstructive Sleep Apnea
Manhattan Beach Orthodontics
NCT04874727
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 2 |
| Phase 3 | 2 |
| Phase 4 | 1 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the OSA Trial Landscape
ClinicalTrials.gov lists 15 US studies indexed under OSA, and 6 of those are currently open to recruitment — roughly 40% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
The phase distribution for OSA shows 3 late-stage studies (Phase 3 and Phase 4 combined) alongside 2 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
Top sponsor activity for OSA is led by Brigham and Women's Hospital with 2 indexed trials, alongside 9 other organizations in the top contributor list. The list on this page surfaces up to 15 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for OSA?
PlainTrial tracks 15 US clinical trials for OSA, of which 6 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for OSA?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology — how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.