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ClinicalTrials.gov 6 recruiting now official registry

OSA clinical trials

Every US clinical trial registered for OSA — phase mix, recruiting status, and the sponsors running them, straight from the NIH ClinicalTrials.gov registry.

15 US clinical trials · 6 currently recruiting

The research picture

OSA has 15 registered US clinical trials, 6 of them open to new participants right now — about 40% of the total.

6
recruiting participants now
40%
of trials open to enrollment
3
in Phase 3–4 (later-stage)
2
top sponsor: Brigham and Women's Hospital

Counts reflect the public ClinicalTrials.gov registry as last mirrored by PlainTrial. Status and phase are reported by each study's sponsor. This is reference information, not medical advice.

Active & Recent Trials

RECRUITING Phase 1 260 participants

Is Obstructive Sleep Apnea Important in the Development of Alzheimer's Disease?

University of California, San Diego

NCT05094271

RECRUITING 60 participants

Diagnosing Obstructive Sleep Apnea Using Electromyography of the Muscles of the Mouth

University of California, San Diego

NCT06944782

RECRUITING NA 36 participants

Mandibular Advancement Device and Changes in Nocturia

Fernanda Yanez Regonesi

NCT05562388

RECRUITING Phase 1 36 participants

Acetazolamide as a Means to Mitigate Falling Ventilatory Drive and Drive-dependent OSA

Brigham and Women's Hospital

NCT06091085

RECRUITING NA 36 participants

Reversible Effect of Falling Ventilatory Drive in Drive-dependent OSA

Brigham and Women's Hospital

NCT06091098

RECRUITING NA 28 participants

The Effect of Interval Exercise on Functional Outcomes in Veterans With COPD and OSA

VA Office of Research and Development

NCT05254431

ACTIVE NOT RECRUITING Phase 3 600 participants

A Master Protocol for Orforglipron in Participants With Obstructive Sleep Apnea and Obesity or Overweight

Eli Lilly and Company

NCT06649045

ACTIVE NOT RECRUITING NA 150 participants

Treating Obstructive Sleep Apnea Using Targeted Hypoglossal Neurostimulation

LivaNova

NCT04950894

COMPLETED Phase 3 660 participants

Parallel Arm Trial of AD109 and Placebo With Patients With OSA (LunAIRo)

Apnimed

NCT05811247

COMPLETED Phase 4 250 participants

Randomized Study of Provent Versus Sham Device to Treat Obstructive Sleep Apnea

Ventus Medical

NCT00772044

COMPLETED 128 participants

Impact of OSA on Outcomes in Acute Coronary Syndrome

MetroHealth Medical Center

NCT03793582

COMPLETED NA 29 participants

Novel by Upper Airway Respiratory Muscle Training to Treat OSA in Chronic SCI

VA Office of Research and Development

NCT03664765

COMPLETED NA 22 participants

Sham CPAP vs. Straight CPAP for Chronic Cough

Krishna M. Sundar

NCT03172130

COMPLETED NA 12 participants

Early Feasibility Study of Transcutaneous Upper Airway Stimulation in Obstructive Sleep Apnea

Somnial

NCT05881512

COMPLETED 6 participants

Comparison of Standing Versus Supine 3D Cone Beam Computed Tomography in Patient With Obstructive Sleep Apnea

Manhattan Beach Orthodontics

NCT04874727

Phase Distribution

PhaseTrial count
Phase 1 2
Phase 3 2
Phase 4 1

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the OSA Trial Landscape

ClinicalTrials.gov lists 15 US studies indexed under OSA, and 6 of those are currently open to recruitment — roughly 40% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

The phase distribution for OSA shows 3 late-stage studies (Phase 3 and Phase 4 combined) alongside 2 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

Top sponsor activity for OSA is led by Brigham and Women's Hospital with 2 indexed trials, alongside 9 other organizations in the top contributor list. The list on this page surfaces up to 15 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for OSA?

PlainTrial tracks 15 US clinical trials for OSA, of which 6 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for OSA?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Related

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

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