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COMPLETED Phase 2

A Study to Evaluate Efficacy and Safety of ALN-AGT01 in Patients With Mild To-Moderate Hypertension

NCT04936035 · View on ClinicalTrials.gov ↗

Study Summary

The purpose of this study is to evaluate the effect of ALN-AGT01 on systolic and diastolic blood pressure and to characterize the pharmacodynamic (PD) effects and safety of ALN-AGT01.

Conditions Studied

Interventions

  • DRUG Placebo
  • DRUG ALN-AGT01

Study Locations (20)

Florida

  • Clinical Trial Site — Clearwater
  • Clinical Trial Site — Coral Gables
  • Clinical Trial Site — Fleming Island
  • Clinical Trial Site — Hollywood
  • Clinical Trial Site — Hollywood
  • Clinical Trial Site — Inverness
  • Clinical Trial Site — Jacksonville
  • Clinical Trial Site — Jacksonville
  • Clinical Trial Site — Jacksonville
  • Clinical Trial Site — Miami

California

  • Clinical Trial Site — Beverly Hills
  • Clinical Trial Site — La Mesa
  • Clinical Trial Site — Los Angeles
  • Clinical Trial Site — San Diego
  • Clinical Trial Site — South Gate
  • Clinical Trial Site — Vista

Arizona

  • Clinical Trial Site — Tempe
  • Clinical Trial Site — Tempe

Alabama

  • Clinical Trial Site — Birmingham

District of Columbia

  • Clinical Trial Site — Washington D.C.

Trial Details

FieldValue
Enrollment Target 394 participants
Start Date 2021-07-07
Est. Completion 2024-12-05
Phase Phase 2

Sponsor

Alnylam Pharmaceuticals

81 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT04936035

The ClinicalTrials.gov registry entry for NCT04936035 describes a study currently listed as completed. It is categorized as Phase 2, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 394 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Alnylam Pharmaceuticals, which has 81 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 1 condition, with Hypertension appearing as the primary indexed condition, and to 2 interventions — of which Placebo is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT04936035 reports 20 study locations spanning 5 distinct geographic areas — top geographies include Florida, California, Arizona. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT04936035 about?

NCT04936035 is a clinical study titled "A Study to Evaluate Efficacy and Safety of ALN-AGT01 in Patients With Mild To-Moderate Hypertension". The purpose of this study is to evaluate the effect of ALN-AGT01 on systolic and diastolic blood pressure and to characterize the pharmacodynamic (PD) effects and safety of ALN-AGT01.

What is the current status of trial NCT04936035?

This trial is currently completed. It is a Phase 2 study. The enrollment target is 394 participants. The study started on 2021-07-07. Estimated completion is 2024-12-05.

What conditions does trial NCT04936035 study?

This clinical trial studies the following conditions: Hypertension. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT04936035?

The interventions under investigation include: Placebo (DRUG), ALN-AGT01 (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT04936035?

This trial is sponsored by Alnylam Pharmaceuticals, which has 81 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT04936035 being conducted?

This trial has 20 study locations across Alabama, Arizona, California, District of Columbia, Florida. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial