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NCT06657924 · ClinicalTrials.gov registry record · Phase 2
Preoperative Tranexamic Acid (TXA) to Prevent Bleeding in Patients Undergoing Major Colorectal Surgery
A Phase 2 study of Bleeding and Thromboembolism, sponsored by Kristen Ban.
- Recruiting
- Registry status
- Phase 2
- Development phase
- 394
- Enrollment target
- 1
- Study location
NCT06657924: Recruiting Phase 2 study of Bleeding and Thromboembolism, sponsored by Kristen Ban.
NCT06657924 is a Phase 2 study of Bleeding and Thromboembolism that is actively recruiting participants, run by Kristen Ban. The registered enrollment target is 394 participants, below the 1,468-participant average among 23 other Bleeding trials with a reported enrollment target (73% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT06657924, a Phase 2 study of Bleeding and Thromboembolism, is actively recruiting participants, sponsored by Kristen Ban.
- RECRUITING
- Registry status
- Phase 2
- Development phase
- 394 participants
- Enrollment target
- 1
- Study location
Study Summary
The goal of this prospective pragmatic randomized clinical trial is to determine if preoperative administration of tranexamic acid (TXA) reduces bleeding during and after major colorectal surgery. The primary questions are: * Does TXA reduce bleeding during and after surgery (change in hemoglobin from before surgery to lowest value after surgery within 30 days) * Does TXA reduce bleeding complications within 30 days of surgery (blood transfusion, return to the operating room or procedural intervention for bleeding, death due to bleeding) * Does TXA increase the risk of thromboembolic complications within 30 days of surgery (cerebrovascular accident, myocardial infarction, deep venous thrombosis, pulmonary embolism) Researchers will compare preoperative TXA to no TXA to answer the above questions. Participants who receive TXA will receive 1 g TXA IV at the beginning and end of surgery in the operating room.
Primary Outcome
Preoperative to lowest postoperative within 30 days of surgery
Conditions Studied
Interventions
- DRUG Tranexamic acid
Study Locations (1)
Ohio
- Cleveland Clinic Fairview Hospital - Cleveland
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 394 participants |
| Start Date | 2025-02-11 |
| Est. Completion | 2026-10-01 |
| Phase | Phase 2 |
What NCT06657924 shows while recruiting
NCT06657924 is an interventional study that assigns participants to a tested intervention. The registered 394 participants enrollment target is mid-sized for trials with a published cap, below the 1,468-participant average among 23 other Bleeding trials with a reported enrollment target (73% lower).
The record links to 4 conditions, with Bleeding appearing as the primary indexed condition, and to 1 intervention - of which Tranexamic acid is the first listed.
NCT06657924 reports a single indexed study location in Ohio.
Frequently Asked Questions
What is clinical trial NCT06657924 about?
NCT06657924 is a clinical study titled "Preoperative Tranexamic Acid (TXA) to Prevent Bleeding in Patients Undergoing Major Colorectal Surgery". The goal of this prospective pragmatic randomized clinical trial is to determine if preoperative administration of tranexamic acid (TXA) reduces bleeding during and after major colorectal surgery. The primary questions are: * Does TXA reduce bleeding during and after surgery (change in hemoglobin f...
What is the current status of trial NCT06657924?
This trial is currently recruiting. It is a Phase 2 study. The enrollment target is 394 participants. The study started on 2025-02-11. Estimated completion is 2026-10-01.
What conditions does trial NCT06657924 study?
This clinical trial studies the following conditions: Bleeding, Thromboembolism, Colorectal Disorders, Tranexamic Acid.
What interventions are being tested in trial NCT06657924?
The interventions under investigation include: Tranexamic acid (DRUG).
Who is sponsoring clinical trial NCT06657924?
This trial is sponsored by Kristen Ban, which has 1 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06657924 being conducted?
This trial has 1 study location across Ohio. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Bleeding
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT06657924's enrollment target sits among peer trials
394 10th of 23 higher than 14 of 23 other Bleeding trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Bleeding trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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