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NCT04856046 · ClinicalTrials.gov registry record
Detection of Plasma DNA Methylation in Peripheral Blood From Patients With Resectable Liver Cancer
A clinical trial of Resectable Hepatocellular Carcinoma, sponsored by Mayo Clinic.
- Active
- Registry status
- 36
- Enrollment target
- 1
- Study location
NCT04856046: Active study of Resectable Hepatocellular Carcinoma, sponsored by Mayo Clinic.
NCT04856046 is a study of Resectable Hepatocellular Carcinoma that is active but no longer recruiting, run by Mayo Clinic. The registered enrollment target is 36 participants, below the 42-participant average among 4 other Resectable Hepatocellular Carcinoma trials with a reported enrollment target (14% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT04856046, a study of Resectable Hepatocellular Carcinoma, is active but no longer recruiting, sponsored by Mayo Clinic.
- ACTIVE NOT RECRUITING
- Registry status
- 36 participants
- Enrollment target
- 1
- Study location
Study Summary
This study explores the potential values of a new blood test approach to detect measurable residual disease or early coming back of cancer (recurrence)/cancer growing, spreading, or getting worse (progression) in patients with liver cancer that can be removed by surgery (resectable). The development of novel cancer biomarkers for liver cancer may help in clinical decision making and lead to improvements in patient outcomes by facilitating prediction of the response to specific treatments, improved monitoring of patients on treatment, and better prognostication of patient outcomes, thus improving stratification for clinical trials.
Primary Outcome
Association between mt-HBT score and patient and tumor characteristics with state occupancy probability will be examined using the Cox proportional hazards model. Serial measurements of the mt-HBT score obtained on subsequent visits will be accounted for within the Cox model by treating them as time varying covariate. To assess the relative importance of the mt-HBT score to individual alpha fetoprotein (AFP) levels for the prediction of hepatocellular carcinoma (HCC) recurrence, the area under t
Conditions Studied
Interventions
- PROCEDURE Biospecimen Collection
- OTHER Electronic Health Record Review
Study Locations (1)
Minnesota
- Mayo Clinic in Rochester - Rochester
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 36 participants |
| Start Date | 2021-11-06 |
| Est. Completion | 2026-04-01 |
What the registry record for NCT04856046 still lists
NCT04856046 is an observational study that tracks outcomes without assigning an intervention. The registry caps enrollment at 36 participants, a relatively small participant target, below the 42-participant average among 4 other Resectable Hepatocellular Carcinoma trials with a reported enrollment target (14% lower).
The record links to 1 condition, with Resectable Hepatocellular Carcinoma appearing as the primary indexed condition, and to 2 interventions - of which Biospecimen Collection is the first listed.
NCT04856046 reports a single indexed study location in Minnesota.
Frequently Asked Questions
What is clinical trial NCT04856046 about?
NCT04856046 is a clinical study titled "Detection of Plasma DNA Methylation in Peripheral Blood From Patients With Resectable Liver Cancer". This study explores the potential values of a new blood test approach to detect measurable residual disease or early coming back of cancer (recurrence)/cancer growing, spreading, or getting worse (progression) in patients with liver cancer that can be removed by surgery (resectable). The development...
What is the current status of trial NCT04856046?
This trial is currently active not recruiting. The enrollment target is 36 participants. The study started on 2021-11-06. Estimated completion is 2026-04-01.
What conditions does trial NCT04856046 study?
This clinical trial studies the following conditions: Resectable Hepatocellular Carcinoma.
What interventions are being tested in trial NCT04856046?
The interventions under investigation include: Biospecimen Collection (PROCEDURE), Electronic Health Record Review (OTHER).
Who is sponsoring clinical trial NCT04856046?
This trial is sponsored by Mayo Clinic, which has 2,844 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT04856046 being conducted?
This trial has 1 study location across Minnesota. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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