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ClinicalTrials.gov 15 recruiting now official registry

B-Cell Non-Hodgkin Lymphoma clinical trials

15 of 25 indexed B-Cell Non-Hodgkin Lymphoma trials are currently recruiting.

25 US clinical trials · 15 currently recruiting

B-Cell Non-Hodgkin Lymphoma is the subject of 25 registered US clinical trials on ClinicalTrials.gov, 15 of them currently open to new participants. 0 are in Phase 3-4 (later-stage) and 24 in Phase 1-2 (earlier-stage). The most active sponsor is AstraZeneca, running 4 of these trials.

The research picture

B-Cell Non-Hodgkin Lymphoma has 25 registered US clinical trials, 15 of them open to new participants right now, about 60% of the total.

15
recruiting participants now
60%
of trials open to enrollment
0
in Phase 3–4 (later-stage)
4
top sponsor: AstraZeneca
Phase 117Phase 27

Active & Recent Trials

25 total, page 1 of 1

RECRUITING Phase 1 317 participants

A Study of AZD0486 in Subjects With B-Cell Non-Hodgkin Lymphoma

AstraZeneca

NCT04594642

RECRUITING Phase 1 276 participants

A Study of AZD0486 Monotherapy or in Combination With Other Anti-Cancer Agents for Mature B-Cell Malignancies

AstraZeneca

NCT06564038

RECRUITING Phase 2 240 participants

Surovatamig (AZD0486) as Monotherapy in Participants With Relapsed/Refractory (R/R) B-cell NHL

AstraZeneca

NCT06526793

RECRUITING Phase 1 200 participants

A Study to Evaluate the Safety and Anti-cancer Activity of Loncastuximab Tesirine in Combination With Other Anti-cancer Agents in Participants With Relapsed or Refractory B-cell Non-Hodgkin Lymphoma (LOTIS-7)

ADC Therapeutics S.A.

NCT04970901

RECRUITING Phase 2 164 participants

Geriatric Assessment Guided Interventions to Accelerate Functional Recovery After CAR-T Therapy for Patients 60 Years and Older With B-cell Non-Hodgkin Lymphoma or Multiple Myeloma, GOCART Study

City of Hope Medical Center

NCT06052826

RECRUITING Phase 1 140 participants

IKS03 in Patients With Advanced B Cell Non-Hodgkin Lymphomas

Iksuda Therapeutics

NCT05365659

RECRUITING Phase 1 127 participants

A Vaccine (VSV-hIFNβ-NIS) With or Without Cyclophosphamide and Combinations of Ipilimumab, Nivolumab, and Cemiplimab in Treating Relapsed or Refractory Multiple Myeloma, Acute Myeloid Leukemia or Lymphoma

Mayo Clinic

NCT03017820

RECRUITING Phase 1 91 participants

A Phase I/II Study of AZD4512 Monotherapy or in Combination With Anticancer Agents in Participants With Relapsed/Refractory B-cell Non-Hodgkin Lymphoma

AstraZeneca

NCT07123454

RECRUITING Phase 1 54 participants

Evaluating the Safety and Efficacy of DuoCAR20.19.22-D95 in Adult Patients With Relapsed or Refractory B-cell Malignancies

University of Kansas Medical Center

NCT06879340

RECRUITING Phase 1 45 participants

UCD19 CarT in Treatment of Pediatric B-ALL and B-NHL

University of Colorado, Denver

NCT04544592

RECRUITING Phase 2 32 participants

Pembrolizumab and Tazemetostat to Overcome Immune Tolerance Following ASCT or CAR T-cell Therapy in Patients With Aggressive B-Cell Non-Hodgkin's Lymphoma

Northwestern University

NCT06242834

RECRUITING Phase 1 27 participants

B-Cell Activating Factor Receptor (BAFFR)-Based Chimeric Antigen Receptor T-Cells With Fludarabine and Cyclophosphamide Lymphodepletion for the Treatment of Relapsed or Refractory B-cell Hematologic Malignancies

Mayo Clinic

NCT06191887

RECRUITING Phase 1 27 participants

Metabolically Fit CD19 CAR T-cell Therapy With CD34 Selection in Patients With CD19+ Relapsed/Refractory NHL, CLL/SLL

Medical University of South Carolina

NCT05702853

RECRUITING Phase 2 18 participants

Epcoritamab With Dose Adjusted Etoposide, Cyclophosphamide, Vincristine, Doxorubicin, Prednisone and Rituximab (EPOCH-R) for the Treatment of Aggressive B-Cell Non-Hodgkin Lymphoma

University of Washington

NCT07097363

RECRUITING Phase 1 15 participants

Genetically Modified T-cells (CMV-Specific CD19-CAR T-cells) Plus a Vaccine (CMV-MVA Triplex) Following Stem Cell Transplantation for the Treatment of Intermediate or High Grade B-cell Non-Hodgkin Lymphoma

City of Hope Medical Center

NCT05432635

ACTIVE NOT RECRUITING 501 participants

DNA Sequencing-Based Monitoring of Minimal Residual Disease to Predict Clinical Relapse in Aggressive B-cell Non-Hodgkin Lymphomas

Memorial Sloan Kettering Cancer Center

NCT02633111

ACTIVE NOT RECRUITING Phase 1 422 participants

A Study to Evaluate the Safety and Efficacy of Mosunetuzumab (BTCT4465A) in Combination With Polatuzumab Vedotin in B-Cell Non-Hodgkin Lymphoma

Hoffmann-La Roche

NCT03671018

ACTIVE NOT RECRUITING Phase 2 80 participants

Tailored Prednisone Reduction in Preventing Hyperglycemia in Participants With B-Cell Non-Hodgkin Lymphoma Receiving Combination Chemotherapy Treatment

Wake Forest University Health Sciences

NCT03505762

ACTIVE NOT RECRUITING Phase 2 62 participants

A Study of Anakinra to Prevent or Treat Severe Side Effects for Patients Receiving CAR-T Cell Therapy

Memorial Sloan Kettering Cancer Center

NCT04148430

ACTIVE NOT RECRUITING Phase 1 44 participants

A Study of Blinatumomab in Patients With Pre B-cell ALL and B-cell NHL as Post-allo-HSCT Remission Maintenance

Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins

NCT03114865

ACTIVE NOT RECRUITING Phase 1 23 participants

Acalabrutinib and Anti-CD19 CAR T-cell Therapy for the Treatment of B-cell Lymphoma

University of Washington

NCT04257578

ACTIVE NOT RECRUITING Phase 1 20 participants

Combination of Pembrolizumab With TGR-1202 in Patients With Relapsed/Refractory CLL and B-cell NHL

University of Chicago

NCT03283137

COMPLETED Phase 1 117 participants

A Phase Ib/II Study Investigating the Safety, Tolerability, Pharmacokinetics, and Efficacy of Mosunetuzumab (BTCT4465A) in Combination With CHOP or CHP-Polatuzumab Vedotin in Participants With B-Cell Non-Hodgkin Lymphoma

Hoffmann-La Roche

NCT03677141

COMPLETED Phase 1 52 participants

Autologous CD22 CAR T Cells in Adults w/ Recurrent or Refractory B Cell Malignancies

Stanford University

NCT04088890

COMPLETED Phase 2 18 participants

CD8+ Memory T-Cells as Consolidative Therapy After Donor Non-myeloablative Hematopoietic Cell Transplant in Treating Patients With Leukemia or Lymphoma

Robert Lowsky

NCT02424968

Phase Distribution

PhaseTrial count
Phase 1 17
Phase 2 7

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the B-Cell Non-Hodgkin Lymphoma Trial Landscape

25 indexed B-Cell Non-Hodgkin Lymphoma studies · 15 recruiting (60%).

Phase mix: 0 late (III/IV) vs 24 early (I/II).

Top sponsor: AstraZeneca (4 trials), 9 others listed. 25 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for B-Cell Non-Hodgkin Lymphoma?

PlainTrial tracks 25 US clinical trials for B-Cell Non-Hodgkin Lymphoma, of which 15 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for B-Cell Non-Hodgkin Lymphoma?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.