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NCT04447651 · ClinicalTrials.gov registry record
Patient Response to Immunotherapy Using Spliceosome Mutational Markers (PRISMM)
A clinical trial of Metastatic Solid Tumor and SF3B1 Gene Mutation, sponsored by Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins.
- Active
- Registry status
- 6
- Enrollment target
- 1
- Study location
NCT04447651: Active study of Metastatic Solid Tumor and SF3B1 Gene Mutation, sponsored by Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins.
NCT04447651 is a study of Metastatic Solid Tumor and SF3B1 Gene Mutation that is active but no longer recruiting, run by Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins. The registered enrollment target is 6 participants, below the 192-participant average among 52 other Metastatic Solid Tumor trials with a reported enrollment target (97% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT04447651, a study of Metastatic Solid Tumor and SF3B1 Gene Mutation, is active but no longer recruiting, sponsored by Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins.
- ACTIVE NOT RECRUITING
- Registry status
- 6 participants
- Enrollment target
- 1
- Study location
Study Summary
This study is being done to see if patients with metastatic solid tumors (hematologic malignancies and lymphoma excluded) who have a specific genetic mutation in patients' tumor (the SF3B1, U2AF1 or SRSF2 mutation), are more likely to respond to immunotherapy agents that are now commercially available.
Primary Outcome
To evaluate the feasibility of conducting a prospective study using online recruitment tools to involve patients and physicians who are not usually served by clinical trials. Measured by enrolling 60 patients over 2 years.
Conditions Studied
Interventions
- OTHER Recommendation for treatment with immunotherapy
Study Locations (1)
Maryland
- Johns Hopkins University - Baltimore
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 6 participants |
| Start Date | 2020-09-17 |
| Est. Completion | 2026-08 |
What the registry record for NCT04447651 still lists
NCT04447651 is an observational study that tracks outcomes without assigning an intervention. The registry caps enrollment at 6 participants, a relatively small participant target, below the 192-participant average among 52 other Metastatic Solid Tumor trials with a reported enrollment target (97% lower).
The record links to 5 conditions, with Metastatic Solid Tumor appearing as the primary indexed condition, and to 1 intervention - of which Recommendation for treatment with immunotherapy is the first listed.
NCT04447651 reports a single indexed study location in Maryland.
Frequently Asked Questions
What is clinical trial NCT04447651 about?
NCT04447651 is a clinical study titled "Patient Response to Immunotherapy Using Spliceosome Mutational Markers (PRISMM)". This study is being done to see if patients with metastatic solid tumors (hematologic malignancies and lymphoma excluded) who have a specific genetic mutation in patients' tumor (the SF3B1, U2AF1 or SRSF2 mutation), are more likely to respond to immunotherapy agents that are now commercially availab...
What is the current status of trial NCT04447651?
This trial is currently active not recruiting. The enrollment target is 6 participants. The study started on 2020-09-17. Estimated completion is 2026-08.
What conditions does trial NCT04447651 study?
This clinical trial studies the following conditions: Metastatic Solid Tumor, SF3B1 Gene Mutation, Spliceosome Mutation, U2AF1 Gene Mutation, SRSF2 Gene Mutation.
What interventions are being tested in trial NCT04447651?
The interventions under investigation include: Recommendation for treatment with immunotherapy (OTHER).
Who is sponsoring clinical trial NCT04447651?
This trial is sponsored by Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, which has 523 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT04447651 being conducted?
This trial has 1 study location across Maryland. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Metastatic Solid Tumor
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Where NCT04447651's enrollment target sits among peer trials
6 53rd of 52 the lowest of 52 other Metastatic Solid Tumor trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Metastatic Solid Tumor trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
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