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NCT04339972 · ClinicalTrials.gov registry record · NA
Low Intensity Focused Ultrasound Pulses (LIFUP) to Modulate Pain
A NA study of Healthy Adults, sponsored by Medical University of South Carolina.
- Completed
- Registry status
- NA
- Development phase
- 29
- Enrollment target
- 1
- Study location
NCT04339972 is a NA study of Healthy Adults that has completed, run by Medical University of South Carolina. The registered enrollment target is 29 participants, below the 86-participant average among 33 other Healthy Adults trials with a reported enrollment target (66% lower). The trial reports 1 study location across 1 state.
The verdict
NCT04339972, a NA study of Healthy Adults, has completed, sponsored by Medical University of South Carolina.
- COMPLETED
- Registry status
- NA
- Development phase
- 29 participants
- Enrollment target
- 1
- Study location
Study Summary
The anterior nuclei of the thalamus in addition to periaqueductal gray (PAG) and rostral ventromedial medulla (RVM) are integral regions of a supraspinal opioidergic structure that regulate pain perception. With the capability to influence deep neurological tissues, low intensity frequency ultrasound pulsation (LIFUP) can likely modulate this circuit and induce analgesia. LIFUP deep brain modulation is achieved by induction of focused mechanical waveforms that traverse the cranium and underlying brain tissue. The low frequency of the ultrasonic wave consequently alters neuronal transmission and causes action potential variations through mechanical means, rather than thermal. The purpose of this study is to examine whether stimulation of the anterior nuclei of the thalamus via LIFUP induces analgesia. We hypothesize that suppression of the anterior nuclei of the thalamus will induce a temporary increase in pain tolerance. Moreover, the behavioral changes in pain will correlate with specific regional BOLD changes during pain.
Conditions Studied
Interventions
- DEVICE LIFUP
- DEVICE Sham LIFUP
Study Locations (1)
South Carolina
- Medical University of South Carolina - Charleston
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 29 participants |
| Start Date | 2019-02-01 |
| Est. Completion | 2021-07-01 |
| Phase | NA |
Interested in This Trial?
Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT04339972
The ClinicalTrials.gov registry entry for NCT04339972 describes a study currently listed as completed, categorized as NA. The registered enrollment target is 29 participants, a figure that helps gauge the scale of data the investigators plan to collect, below the 86-participant average among 33 other Healthy Adults trials with a reported enrollment target (66% lower). The listed sponsor is Medical University of South Carolina, which has 755 total studies on file at ClinicalTrials.gov.
The record links to 1 condition, with Healthy Adults appearing as the primary indexed condition, and to 2 interventions - of which LIFUP is the first listed.
NCT04339972 reports 1 study location spanning 1 distinct geographic area - top geographies include South Carolina.
Frequently Asked Questions
What is clinical trial NCT04339972 about?
NCT04339972 is a clinical study titled "Low Intensity Focused Ultrasound Pulses (LIFUP) to Modulate Pain". The anterior nuclei of the thalamus in addition to periaqueductal gray (PAG) and rostral ventromedial medulla (RVM) are integral regions of a supraspinal opioidergic structure that regulate pain perception. With the capability to influence deep neurological tissues, low intensity frequency ultrasoun...
What is the current status of trial NCT04339972?
This trial is currently completed. It is a NA study. The enrollment target is 29 participants. The study started on 2019-02-01. Estimated completion is 2021-07-01.
What conditions does trial NCT04339972 study?
This clinical trial studies the following conditions: Healthy Adults.
What interventions are being tested in trial NCT04339972?
The interventions under investigation include: LIFUP (DEVICE), Sham LIFUP (DEVICE).
Who is sponsoring clinical trial NCT04339972?
This trial is sponsored by Medical University of South Carolina, which has 755 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT04339972 being conducted?
This trial has 1 study location across South Carolina. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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Related
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