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NCT06929455 · ClinicalTrials.gov registry record · NA
Using Bitter Taste Receptor Blockers to Improve the Palatability of Pediatric Medicines
A NA study of Healthy Adults, sponsored by Monell Chemical Senses Center.
- Recruiting
- Registry status
- NA
- Development phase
- 100
- Enrollment target
- 1
- Study location
NCT06929455: Recruiting NA study of Healthy Adults, sponsored by Monell Chemical Senses Center.
NCT06929455 is a NA study of Healthy Adults that is actively recruiting participants, run by Monell Chemical Senses Center. The registered enrollment target is 100 participants, above the 83-participant average among 33 other Healthy Adults trials with a reported enrollment target (20% higher). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT06929455, a NA study of Healthy Adults, is actively recruiting participants, sponsored by Monell Chemical Senses Center.
- RECRUITING
- Registry status
- NA
- Development phase
- 100 participants
- Enrollment target
- 1
- Study location
Study Summary
Many people, particularly small children, must take drugs in liquid form because they cannot swallow pills or capsules. The bad taste of some liquid drugs can keep patients from taking drugs they need for their health. Our main goal in this research study is find ingredients that might make drugs taste better. Participants in this research study will be healthy adults between the ages of 18 and 60 years old. Participants will taste samples (liquids or gels) containing active pharmaceutical ingredients (substances in medications that produce desired health effects). After tasting each sample participants will spit out the sample and rinse with water (no samples will be swallowed). Active pharmaceutical ingredients of current interest are: 1) tenofovir alafenamide, used to treat HIV infection and hepatitis B, 2) rifampicin, used to treat tuberculosis, 3) rifapentine, used to treat tuberculosis, and 4) levofloxacin, used to treat various bacterial infections). Other active pharmaceutical ingredients may be added as the study goes forward. Participants will be instructed to taste samples both with and without experimental flavor ingredients added and judge how the samples taste. People who volunteer for the study will be instructed to complete many repeated visits to the Monell Center (University City area of Philadelphia) for tasting sessions. Tasting visits will last between 1 and 2 hours.
Primary Outcome
Ratings of oral sensation (e.g., bitterness, sourness, astringency, etc.) made using the general Labeled Magnitude Scale. Values range from 0 (no sensation) to 100 (strongest imaginable sensation)
Conditions Studied
Interventions
- OTHER Flavor additives
Study Locations (1)
Pennsylvania
- Monell Chemical Senses Center - Philadelphia
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 100 participants |
| Start Date | 2025-03-18 |
| Est. Completion | 2026-11-01 |
| Phase | NA |
What NCT06929455 shows while recruiting
NCT06929455 is an interventional study that assigns participants to a tested intervention. The registered 100 participants enrollment target is mid-sized for trials with a published cap, above the 83-participant average among 33 other Healthy Adults trials with a reported enrollment target (20% higher).
The record links to 1 condition, with Healthy Adults appearing as the primary indexed condition, and to 1 intervention - of which Flavor additives is the first listed.
NCT06929455 reports a single indexed study location in Pennsylvania.
Frequently Asked Questions
What is clinical trial NCT06929455 about?
NCT06929455 is a clinical study titled "Using Bitter Taste Receptor Blockers to Improve the Palatability of Pediatric Medicines". Many people, particularly small children, must take drugs in liquid form because they cannot swallow pills or capsules. The bad taste of some liquid drugs can keep patients from taking drugs they need for their health. Our main goal in this research study is find ingredients that might make drugs ta...
What is the current status of trial NCT06929455?
This trial is currently recruiting. It is a NA study. The enrollment target is 100 participants. The study started on 2025-03-18. Estimated completion is 2026-11-01.
What conditions does trial NCT06929455 study?
This clinical trial studies the following conditions: Healthy Adults.
What interventions are being tested in trial NCT06929455?
The interventions under investigation include: Flavor additives (OTHER).
Who is sponsoring clinical trial NCT06929455?
This trial is sponsored by Monell Chemical Senses Center, which has 16 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06929455 being conducted?
This trial has 1 study location across Pennsylvania. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Healthy Adults
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT06929455's enrollment target sits among peer trials
100 6th of 33 higher than 27 of 33 other Healthy Adults trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Healthy Adults trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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