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NCT03577431 · ClinicalTrials.gov registry record · Phase 1

Liver Transplantation With Tregs at MGH

A Phase 1 study of Liver Transplant, sponsored by National Institute of Allergy and Infectious Diseases (NIAID).

Active
Registry status
Phase 1
Development phase
9
Enrollment target
1
Study location

NCT03577431: Active Phase 1 study of Liver Transplant, sponsored by National Institute of Allergy and Infectious Diseases (NIAID).

NCT03577431 is a Phase 1 study of Liver Transplant that is active but no longer recruiting, run by National Institute of Allergy and Infectious Diseases (NIAID). The registered enrollment target is 9 participants, below the 5,458-participant average among 19 other Liver Transplant trials with a reported enrollment target (100% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.

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The verdict

NCT03577431, a Phase 1 study of Liver Transplant, is active but no longer recruiting, sponsored by National Institute of Allergy and Infectious Diseases (NIAID).

ACTIVE NOT RECRUITING
Registry status
Phase 1
Development phase
9 participants
Enrollment target
1
Study location

Study Summary

This is a single-center, prospective, open-label, non-randomized clinical trial exploring cellular therapy to facilitate immunosuppression withdrawal in liver transplant recipients.

Primary Outcome

The number of AEs attributed to the investigational product, arTreg-CSB. AEs will be attributed to arTreg-CSB when the AE is reported with possible or related attribution to arTreg-CSB.

Conditions Studied

Liver Transplant

Interventions

  • DRUG cyclophosphamide
  • DRUG everolimus
  • PROCEDURE leukapheresis
  • BIOLOGICAL arTreg-CSB
  • DRUG mesna

Study Locations (1)

Massachusetts

  • Massachusetts General Hospital: Transplantation - Boston

Trial Details

FieldValue
Enrollment Target 9 participants
Start Date 2019-03-29
Est. Completion 2027-04-06
Phase Phase 1
National Institute of Allergy and Infectious Diseases (NIAID)

2,006 total trials

What the registry record for NCT03577431 still lists

NCT03577431 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 9 participants, a relatively small participant target, below the 5,458-participant average among 19 other Liver Transplant trials with a reported enrollment target (100% lower).

The record links to 1 condition, with Liver Transplant appearing as the primary indexed condition, and to 5 interventions - of which cyclophosphamide is the first listed.

NCT03577431 reports a single indexed study location in Massachusetts.

Frequently Asked Questions

What is clinical trial NCT03577431 about?

NCT03577431 is a clinical study titled "Liver Transplantation With Tregs at MGH". This is a single-center, prospective, open-label, non-randomized clinical trial exploring cellular therapy to facilitate immunosuppression withdrawal in liver transplant recipients.

What is the current status of trial NCT03577431?

This trial is currently active not recruiting. It is a Phase 1 study. The enrollment target is 9 participants. The study started on 2019-03-29. Estimated completion is 2027-04-06.

What conditions does trial NCT03577431 study?

This clinical trial studies the following conditions: Liver Transplant.

What interventions are being tested in trial NCT03577431?

The interventions under investigation include: cyclophosphamide (DRUG), everolimus (DRUG), leukapheresis (PROCEDURE), arTreg-CSB (BIOLOGICAL), mesna (DRUG).

Who is sponsoring clinical trial NCT03577431?

This trial is sponsored by National Institute of Allergy and Infectious Diseases (NIAID), which has 2,006 total clinical trials registered on ClinicalTrials.gov.

Where is trial NCT03577431 being conducted?

This trial has 1 study location across Massachusetts. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Learn More About Clinical Trials

Similar trials for Liver Transplant

Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.

Where NCT03577431's enrollment target sits among peer trials

9 20th of 19 the lowest of 19 other Liver Transplant trials

participants (enrollment target), bucketed by value

Each bar is a band; taller bars hold more other Liver Transplant trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.

Source ClinicalTrials.gov registry export · 2026-08-08

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Related registry views

Source: ClinicalTrials.gov NCT03577431, the US trial registry maintained by the National Library of Medicine. NCT03577431 (small enrollment · single site footprint · active not recruiting) retrieved and formatted by PlainTrial, see methodology.