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NCT00001595 · ClinicalTrials.gov registry record
An Investigation of Pituitary Tumors and Related Hypothalmic Disorders
A clinical trial of Cushing Disease and Panhypopituitarism, sponsored by Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD).
- Recruiting
- Registry status
- 2,000
- Enrollment target
- 1
- Study location
NCT00001595 is a study of Cushing Disease and Panhypopituitarism that is actively recruiting participants, run by Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD). The registered enrollment target is 2,000 participants, above the 143-participant average among 8 other Cushing Disease trials with a reported enrollment target (1299% higher). The trial reports 1 study location across 1 state.
The verdict
NCT00001595, a study of Cushing Disease and Panhypopituitarism, is actively recruiting participants, sponsored by Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD).
- RECRUITING
- Registry status
- 2,000 participants
- Enrollment target
- 1
- Study location
Study Summary
There is a variety of tumors affecting the pituitary gland in childhood; some of these tumors (eg craniopharyngioma) are included among the most common central nervous system tumors in childhood. The gene(s) involved in the pathogenesis of these tumors are largely not known; their possible association with other developmental defects or inheritance pattern(s) has not been investigated. The present study serves as a (i) screening/training, and, (ii) a research protocol. As a screening and training study, this protocol allows our Institute to admit children with tumors of the hypothalamic-pituitary unit to the pediatric endocrine clinics and wards of the NIH Clinical Center for the purposes of (i) training our fellows and students in the identification of genetic defects associated with pituitary tumor formation, and (ii) teaching our fellows and students the recognition, management and complications of pituitary tumors As a research study, this protocol aims at (i) developing new clinical studies for the recognition and therapy of pituitary tumors; as an example, two new studies have emerged within the context of this protocol: (a) investigation of a new research magnetic resonance imaging (MRI) tool and its usefulness in the identification of pituitary tumors, and (b) investigation of the psychological effects of cortisol secretion in pediatric patients with Cushing disease. Continuation of this protocol will eventually lead to new, separate protocols that will address all aspects of diagnosis of pituitary tumors and their therapy in childhood. (ii) Identifying the genetic components of pituitary oncogenesis; those will be investigated by (a) studying the inheritance pattern of pituitary tumors in childhood and their possible association with other conditions in the families of the patients, and (ii) collecting tumor tissues and examining their molecular genetics. As with the clinical studies, the present protocol may help generate ideas for future studies on
Conditions Studied
Interventions
- PROCEDURE MRI
- PROCEDURE Tissue specimen collection
Study Locations (1)
Maryland
- National Institutes of Health Clinical Center - Bethesda
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 2,000 participants |
| Start Date | 1997-04-21 |
Sponsor
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)305 total trials
Interested in This Trial?
Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT00001595
The ClinicalTrials.gov registry entry for NCT00001595 describes a study currently listed as recruiting, categorized as an unspecified phase. The registered enrollment target is 2,000 participants, a figure that helps gauge the scale of data the investigators plan to collect, above the 143-participant average among 8 other Cushing Disease trials with a reported enrollment target (1299% higher). The listed sponsor is Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), which has 305 total studies on file at ClinicalTrials.gov.
The record links to 4 conditions, with Cushing Disease appearing as the primary indexed condition, and to 2 interventions - of which MRI is the first listed.
NCT00001595 reports 1 study location spanning 1 distinct geographic area - top geographies include Maryland.
Frequently Asked Questions
What is clinical trial NCT00001595 about?
NCT00001595 is a clinical study titled "An Investigation of Pituitary Tumors and Related Hypothalmic Disorders". There is a variety of tumors affecting the pituitary gland in childhood; some of these tumors (eg craniopharyngioma) are included among the most common central nervous system tumors in childhood. The gene(s) involved in the pathogenesis of these tumors are largely not known; their possible associati...
What is the current status of trial NCT00001595?
This trial is currently recruiting. The enrollment target is 2,000 participants. The study started on 1997-04-21.
What conditions does trial NCT00001595 study?
This clinical trial studies the following conditions: Cushing Disease, Panhypopituitarism, Gigantism/Acromegaly, Prolactinoma.
What interventions are being tested in trial NCT00001595?
The interventions under investigation include: MRI (PROCEDURE), Tissue specimen collection (PROCEDURE).
Who is sponsoring clinical trial NCT00001595?
This trial is sponsored by Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), which has 305 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT00001595 being conducted?
This trial has 1 study location across Maryland. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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