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NCT05705492 · ClinicalTrials.gov registry record · Phase 2
Olanzapine for the Management of Cancer Associated Appetite Loss in Patients With Advanced Esophagogastric, Hepatopancreaticobiliary, Colorectal or Lung Cancer
A Phase 2 study of Advanced Malignant Solid Neoplasm and Advanced Lung Carcinoma, sponsored by OHSU Knight Cancer Institute.
- Recruiting
- Registry status
- Phase 2
- Development phase
- 66
- Enrollment target
- 1
- Study location
NCT05705492: Recruiting Phase 2 study of Advanced Malignant Solid Neoplasm and Advanced Lung Carcinoma, sponsored by OHSU Knight Cancer Institute.
NCT05705492 is a Phase 2 study of Advanced Malignant Solid Neoplasm and Advanced Lung Carcinoma that is actively recruiting participants, run by OHSU Knight Cancer Institute. The registered enrollment target is 66 participants, below the 176-participant average among 108 other Advanced Malignant Solid Neoplasm trials with a reported enrollment target (62% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT05705492, a Phase 2 study of Advanced Malignant Solid Neoplasm and Advanced Lung Carcinoma, is actively recruiting participants, sponsored by OHSU Knight Cancer Institute.
- RECRUITING
- Registry status
- Phase 2
- Development phase
- 66 participants
- Enrollment target
- 1
- Study location
Study Summary
This phase II trial tests how well olanzapine works in managing cancer cachexia in patients experiencing esophagogastric, hepatopancreaticobiliary, colorectal, or lung cancer that may have spread from where it first started to nearby tissue, lymph nodes, or distant parts of the body (advanced) or that has spread from where it first started (primary site) to other places in the body (metastatic) -associated appetite loss while receiving non-curative cancer therapy. Loss of appetite ("anorexia") in the setting of cancer is a key feature of "cachexia," a syndrome associated with loss of weight and muscle as well as weakness and fatigue. Olanzapine is a drug that targets key neurotransmitters (a type of molecule in the central nervous system that transmits messages to the rest of the body) that may stimulate appetite, restore caloric intake, minimize weight loss, and improve quality of life (QOL).
Primary Outcome
\>5% weight gain comparing olanzapine 2.5mg (Arm I) vs. placebo (Arm III)
Conditions Studied
Interventions
- OTHER Questionnaire Administration
- DRUG Placebo Administration
- DRUG Olanzapine
Study Locations (1)
Oregon
- OHSU Knight Cancer Institute - Portland
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 66 participants |
| Start Date | 2024-07-17 |
| Est. Completion | 2026-12-31 |
| Phase | Phase 2 |
What NCT05705492 shows while recruiting
NCT05705492 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 66 participants, a relatively small participant target, below the 176-participant average among 108 other Advanced Malignant Solid Neoplasm trials with a reported enrollment target (62% lower).
The record links to 10 conditions, with Advanced Malignant Solid Neoplasm appearing as the primary indexed condition, and to 3 interventions - of which Questionnaire Administration is the first listed.
NCT05705492 reports a single indexed study location in Oregon.
Frequently Asked Questions
What is clinical trial NCT05705492 about?
NCT05705492 is a clinical study titled "Olanzapine for the Management of Cancer Associated Appetite Loss in Patients With Advanced Esophagogastric, Hepatopancreaticobiliary, Colorectal or Lung Cancer". This phase II trial tests how well olanzapine works in managing cancer cachexia in patients experiencing esophagogastric, hepatopancreaticobiliary, colorectal, or lung cancer that may have spread from where it first started to nearby tissue, lymph nodes, or distant parts of the body (advanced) or th...
What is the current status of trial NCT05705492?
This trial is currently recruiting. It is a Phase 2 study. The enrollment target is 66 participants. The study started on 2024-07-17. Estimated completion is 2026-12-31.
What conditions does trial NCT05705492 study?
This clinical trial studies the following conditions: Advanced Malignant Solid Neoplasm, Advanced Lung Carcinoma, Advanced Biliary Tract Carcinoma, Locally Advanced Hepatocellular Carcinoma, Locally Advanced Gastric Carcinoma.
What interventions are being tested in trial NCT05705492?
The interventions under investigation include: Questionnaire Administration (OTHER), Placebo Administration (DRUG), Olanzapine (DRUG).
Who is sponsoring clinical trial NCT05705492?
This trial is sponsored by OHSU Knight Cancer Institute, which has 211 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT05705492 being conducted?
This trial has 1 study location across Oregon. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Advanced Malignant Solid Neoplasm
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT05705492's enrollment target sits among peer trials
66 35th of 108 higher than 73 of 108 other Advanced Malignant Solid Neoplasm trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Advanced Malignant Solid Neoplasm trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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