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NCT00390871 · ClinicalTrials.gov registry record · Phase 2
Acute Neurological ICU Sedation Trial (ANIST)
A Phase 2 study of Sedation, sponsored by Johns Hopkins University.
- Completed
- Registry status
- Phase 2
- Development phase
- 35
- Enrollment target
- 1
- Study location
NCT00390871: Completed Phase 2 study of Sedation, sponsored by Johns Hopkins University.
NCT00390871 is a Phase 2 study of Sedation that has completed, run by Johns Hopkins University. The registered enrollment target is 35 participants, below the 100,183-participant average among 12 other Sedation trials with a reported enrollment target (100% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT00390871, a Phase 2 study of Sedation, has completed, sponsored by Johns Hopkins University.
- COMPLETED
- Registry status
- Phase 2
- Development phase
- 35 participants
- Enrollment target
- 1
- Study location
Study Summary
Dexmedetomidine (Precedex, Hospira) is a "super" selective alpha2-agonist - 8-10x more avid binding to alpha2 receptors than clonidine - and may have particularly favorable characteristics as a continuous i.v. infusion sedative for critically ill neuroscience patients. Its combination of anxiolysis, analgesia, without undue lethargy may make it an ideal agent where frequent neurological examinations are important. Unclear, however, is whether Precedex is superior to current common i.v. sedation protocols, and if there are any undue concerns of this agent on cerebral physiology and cortical stimulation.
Primary Outcome
Cognitive assessment tool
Conditions Studied
Interventions
- DRUG Fentanyl
- DRUG Fentanyl/Dexmedetomidine
- DRUG Fentanyl/Propofol
Study Locations (1)
Maryland
- Johns Hopkins University - Baltimore
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 35 participants |
| Start Date | 2005-05 |
| Est. Completion | 2007-12 |
| Phase | Phase 2 |
What the finished NCT00390871 record still lists
NCT00390871 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 35 participants, a relatively small participant target, below the 100,183-participant average among 12 other Sedation trials with a reported enrollment target (100% lower).
The record links to 1 condition, with Sedation appearing as the primary indexed condition, and to 3 interventions - of which Fentanyl is the first listed.
NCT00390871 reports a single indexed study location in Maryland.
Frequently Asked Questions
What is clinical trial NCT00390871 about?
NCT00390871 is a clinical study titled "Acute Neurological ICU Sedation Trial (ANIST)". Dexmedetomidine (Precedex, Hospira) is a "super" selective alpha2-agonist - 8-10x more avid binding to alpha2 receptors than clonidine - and may have particularly favorable characteristics as a continuous i.v. infusion sedative for critically ill neuroscience patients. Its combination of anxiolysis,...
What is the current status of trial NCT00390871?
This trial is currently completed. It is a Phase 2 study. The enrollment target is 35 participants. The study started on 2005-05. Estimated completion is 2007-12.
What conditions does trial NCT00390871 study?
This clinical trial studies the following conditions: Sedation.
What interventions are being tested in trial NCT00390871?
The interventions under investigation include: Fentanyl (DRUG), Fentanyl/Dexmedetomidine (DRUG), Fentanyl/Propofol (DRUG).
Who is sponsoring clinical trial NCT00390871?
This trial is sponsored by Johns Hopkins University, which has 1,448 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT00390871 being conducted?
This trial has 1 study location across Maryland. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Sedation
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT00390871's enrollment target sits among peer trials
35 11th of 12 higher than 2 of 12 other Sedation trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Sedation trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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ACTIVE NOT RECRUITING · Phase 3
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