Otsuka Pharmaceutical Development & Commercialization

Open enrollment across a mixed-phase pipeline

According to ClinicalTrials.gov-derived indexes, Otsuka Pharmaceutical Development & Commercialization sits in the top decile of US sponsors by registered trial count (#145 of 15,742 sponsors by registered trial count).

221 total trials 8 currently recruiting 186 completed top decile by trial count

Otsuka Pharmaceutical Development & Commercialization: 221 sponsored US clinical trials, 8 recruiting.

Otsuka Pharmaceutical Development & Commercialization sponsors 221 registered US clinical trials on ClinicalTrials.gov, 8 of them currently recruiting, and 186 completed. 119 of these trials are in Phase 3-4 (later-stage) and 97 in Phase 1-2 (earlier-stage). The most-studied condition in this pipeline is Schizophrenia, with 12 trials.

Top-decile sponsor footprint

Otsuka Pharmaceutical Development & Commercialization ranks in the top decile of sponsors by registered trial count (#145 of 15,742 sponsors by registered trial count). Volume at this scale usually reflects a long institutional pipeline, read phase tilt and therapeutic areas below before treating it as current-year activity.

Trial completion reliability score

D 63/100

186 of 208 decided trials (Completed vs. Terminated on ClinicalTrials.gov) reached their planned completion (89.4%), vs. national p10 68.4% / p90 100% among 1,234 sponsors with at least 10 decided trials. Still-open trials (Recruiting, Active-not-recruiting, Not-yet-recruiting) are excluded since they have not reached an outcome yet.

Open and recent trials

221 total, page 4 of 5

COMPLETED Phase 2

Dasatinib Added to Gemcitabine for Subjects With Locally-advanced Pancreatic Cancer

NCT01395017

COMPLETED Phase 1

Trial Evaluating OPC-34712 in Subjects With Normal Renal Function and Renally Impaired Subjects

NCT01289080

COMPLETED Phase 1

A Study Evaluating the of OPC-34712 in Subjects With Normal Hepatic Function and Hepatically Impaired Subjects

NCT01299454

TERMINATED Phase 3

Study to Evaluate the Efficacy, Safety and Tolerability of an Oral Aripiprazole/Escitalopram Combination Therapy in Participants With Major Depressive Disorder (MDD)

NCT01111565

COMPLETED Phase 2

Dose-finding Study of New Tolvaptan Formulation in Subjects With ADPKD

NCT01210560

TERMINATED Phase 3

Effects of Tolvaptan vs Fluid Restriction in Hospitalized Subjects With Dilutional Hyponatremia

NCT01227512

TERMINATED Phase 3

Study to Evaluate the Efficacy, Safety and Tolerability of an Oral Aripiprazole/Escitalopram Combination Therapy in Participants With Major Depressive Disorder (MDD)

NCT01111552

TERMINATED Phase 3

Study to Evaluate the Efficacy, Safety and Tolerability of an Oral Aripiprazole/Escitalopram Combination Therapy in Participants With Major Depressive Disorder (MDD)

NCT01111539

TERMINATED Phase 3

Safety and Tolerability of Aripiprazole in Adolescents With Schizophrenia or Children and Adolescents With Bipolar I Disorder, Manic or Mixed Episode With or Without Psychotic Features.

NCT01122927

COMPLETED Phase 3

An Open-Label, Multicenter, Rollover, Long-term Study of Aripiprazole Intramuscular Depot in Participants With Schizophrenia

NCT01129882

COMPLETED Phase 3

Tolvaptan Extension Study in Participants With ADPKD

NCT01214421

COMPLETED Phase 2

IV Busulfan Plus Bortezomib Conditioning Regimen for Second Autologous Stem Cell Transplant in Multiple Myeloma Patients

NCT01009840

COMPLETED Phase 2

Study of the Safety and Efficacy of OPC-34712 as a Complementary Therapy in the Treatment of Adult Attention Deficit/Hyperactivity Disorder

NCT01074294

COMPLETED Phase 2

Study of the Safety and Efficacy of OPC-34712 as Adjunctive Therapy in the Treatment of Adults With Major Depressive Disorder

NCT01052077

COMPLETED Phase 1

Phase 1, Open-label Trial to Determine Safety of OPB-51602 in Subjects With Advanced Cancer

NCT01423903

COMPLETED Phase 2

PK-directed Dose Adjustment of IV Busulfan Conditioning Regimen for Autologous Stem Cell Transplant in Lymphoma Patients

NCT00948090

COMPLETED Phase 2

Study of Safety & Tolerability of OPC-34712 as Adjunctive Therapy in Treatment of Adult Patients With Major Depressive Disorder

NCT01447576

COMPLETED Phase 2

Multicenter, Open-label, Safety and Tolerability Study

NCT01649557

COMPLETED Phase 2

Study to Evaluate the Efficacy, Safety, and Tolerability of Oral OPC-34712 and Aripiprazole for Treatment of Acute Schizophrenia

NCT00905307

COMPLETED Phase 2

Study of the Safety and Efficacy of OPC-34712 as Adjunctive Therapy in the Treatment of Patients With Major Depressive Disorder

NCT00797966

TERMINATED Phase 2

Pilot Study of Tetomilast in Chronic Obstructive Pulmonary Disease (COPD) Associated With Emphysema

NCT00874497

COMPLETED Phase 3

Intramuscular Depot Formulation of Aripiprazole as Maintenance Treatment in Patients With Schizophrenia

NCT00731549

COMPLETED Phase 3

Intramuscular Depot Formulation of Aripiprazole as Maintenance Treatment in Patients With Schizophrenia

NCT00706654

COMPLETED Phase 3

Intramuscular Depot Formulation of Aripiprazole as Maintenance Treatment in Patients With Schizophrenia

NCT00705783

COMPLETED Phase 2

A Trial to Evaluate OPC 67683 in Participants With Pulmonary Sputum Culture-positive, Multidrug-resistant Tuberculosis (TB)

NCT00685360

COMPLETED Phase 1

A Multiple Dose Safety, Tolerability and Pharmacokinetics Study in Adult Patients With Schizophrenia Following Administration of Aripiprazole IM Depot

NCT01870999

COMPLETED Phase 3

Effects of Titrated Oral Tolvaptan 15-60 mg Once Daily (QD) on Cognitive and Neurological Function in Elderly Hyponatremic Patients

NCT00550459

COMPLETED Phase 3

Tolvaptan Phase 3 Efficacy and Safety Study in Autosomal Dominant Polycystic Kidney Disease (ADPKD)

NCT00428948

COMPLETED Phase 3

Study of Aripiprazole in the Treatment of Serious Behavioral Problems in Children and Adolescents With Autistic Disorder (AD)

NCT00365859

COMPLETED Phase 1

Aripiprazole and Effexor XR Drug Interaction Study

NCT00362271

COMPLETED Phase 1

Aripiprazole and Lexapro Drug Interaction Study

NCT00361790

COMPLETED Phase 1

Drug-drug Interaction Study of Aripiprazole and Lamotrigine in Patients With Bipolar Type I Disorder

NCT00321516

COMPLETED Phase 4

Aripiprazole Used as Dual Therapy in the Treatement of Patients With Chronic Stable Schizophrenia or Schizoaffective Disorder.

NCT00325689

COMPLETED Phase 3

Study of Aripiprazole in the Treatment of Children and Adolescents With Autistic Disorder (AD)

NCT00337571

COMPLETED Phase 3

Study of Aripiprazole in the Treatment of Children and Adolescents With Autistic Disorder (AD).

NCT00332241

COMPLETED Phase 4

A Phase IV Study of the Safety and Efficacy of Aripiprazole in Combination With Lamotrigine in the Long-Term Maintenance Treatment of Patients With Bipolar I Disorder With A Recent Manic or Mixed Episode

NCT00277212

COMPLETED Phase 2

Tolvaptan Open-label Pilot Efficacy, Tolerability, and Safety Study in Autosomal Dominant Polycystic Kidney Disease (ADPKD)

NCT00413777

COMPLETED Phase 4

A Study of Aripiprazole (Abilify) in Patients With Bipolar Mania

NCT00261443

COMPLETED Phase 3

A Study of Aripiprazole in Patients With Major Depressive Disorder

NCT00105196

COMPLETED Phase 3

Aripiprazole in Children and Adolescents With Bipolar I Disorder

NCT00110461

COMPLETED Phase 2

Heart Pressure Assessment Study With Tolvaptan to Treat Congestive Heart Failure

NCT00132886

COMPLETED Phase 3

Study of Aripiprazole in Patients With Acute Bipolar Mania

NCT00097266

COMPLETED Phase 3

Study of Aripiprazole in Patients With Bipolar I Disorder

NCT00257972

COMPLETED Phase 3

A Long-Term Study of Aripiprazole in Patients With Major Depressive Disorder

NCT00095745

COMPLETED Phase 3

Aripiprazole Open-Label, Safety and Tolerability Study

NCT00102518

COMPLETED Phase 3

Aripiprazole in Adolescents With Schizophrenia

NCT00102063

COMPLETED Phase 3

A Study of Aripiprazole in Patients With Bipolar I Disorder With a Major Depressive Episode

NCT00094432

COMPLETED Phase 3

Aripiprazole in Patients With Acute Mania

NCT00095511

COMPLETED Phase 3

Study of Rebamipide Eye Drops to Treat Dry Eye

NCT00201955

COMPLETED Phase 3

A 1-Year Study in Multiple Clinics Testing Rebamipide Eye Drops for Dry Eye Compared With a Placebo

NCT00201981

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Phase Distribution

PhaseTrial count
Phase 1 52
Phase 2 45
Phase 3 109
Phase 4 10

What is open in the Otsuka Pharmaceutical Development & Commercialization pipeline

8 recruiting of 221 indexed (4% open); 186 completed (84%).

Phase mix: 119 late (III/IV) vs 97 early (I/II) (balanced across stages).

Top condition: Schizophrenia (12 trials), 9 others listed.

How open-pipeline share is computed

Recruiting share is recruiting_count divided by trial_count for this sponsor in the public registry export. Status can change between pulls; treat the figure as a research-attention snapshot, not product availability.

Otsuka Pharmaceutical Development & Commercialization: open-pipeline peers nationwide

Peers matched on 221 registered trials and 4% open enrollment, not the therapeutic-area sidebar.

Otsuka Pharmaceutical Development & Commercialization sits at or above the median trial volume and at or above the median recruiting share among these 9 nationwide peers -- the two do not always move together. Source: ClinicalTrials.gov (2026-08-08 snapshot). 2×2 strategic matrix plotting 9 entities by Total trials (X) and Recruiting share (Y), with a crosshair dividing the plot into four quadrants. Higher volume & more openFocused & more openHigher volume, mostly closedSmaller & mostly closed 050100150200250 0%5%10%15%20%25% Total trials Recruiting share Otsuka Pharmaceutical Development & CommercializationNational Eye Institute (NEI)Florida State UniversityPenn State UniversityUniversity of LouisvilleTeva Branded Pharmaceutical Products R&DBausch Health AmericasHarvard Pilgrim Health CareSumitomo Pharma America
Otsuka Pharmaceutical Development & Commercialization sits at or above the median trial volume and at or above the median recruiting share among these 9 nationwide peers -- the two do not always move together. Source: ClinicalTrials.gov (2026-08-08 snapshot).

Otsuka Pharmaceutical Development & Commercialization sits at or above the median trial volume and at or above the median recruiting share among these 9 nationwide peers -- the two do not always move together.

Sponsors near 221 trials (± recruiting share)

Sponsors near 4% open enrollment (± trial volume)

What to do with this Otsuka Pharmaceutical Development & Commercialization page

221 registered trials is a research-attention snapshot, not an endorsement of Otsuka Pharmaceutical Development & Commercialization or any single study.

  • 8 of Otsuka Pharmaceutical Development & Commercialization's trials are currently recruiting, check each one's own eligibility criteria before contacting a site. Browse recruiting trials
  • Schizophrenia is the condition Otsuka Pharmaceutical Development & Commercialization studies most, compare against other sponsors active in the same condition before evaluating a specific study. See Schizophrenia trials
  • Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide

Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. Otsuka Pharmaceutical Development & Commercialization pipeline card: 221 registered trials from official public datasets. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.