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ClinicalTrials.gov 8 recruiting now official registry

Nervous System Diseases clinical trials

Every US clinical trial registered for Nervous System Diseases — phase mix, recruiting status, and the sponsors running them, straight from the NIH ClinicalTrials.gov registry.

24 US clinical trials · 8 currently recruiting

The research picture

Nervous System Diseases has 24 registered US clinical trials, 8 of them open to new participants right now — about 33% of the total.

8
recruiting participants now
33%
of trials open to enrollment
4
in Phase 3–4 (later-stage)
3
top sponsor: Otsuka Pharmaceutical Development & Commercialization

Counts reflect the public ClinicalTrials.gov registry as last mirrored by PlainTrial. Status and phase are reported by each study's sponsor. This is reference information, not medical advice.

Active & Recent Trials

RECRUITING 3,000 participants

Rett Syndrome Registry

International Rett Syndrome Foundation

NCT05432349

RECRUITING NA 500 participants

Neurologic Stem Cell Treatment Study

MD Stem Cells

NCT02795052

RECRUITING Phase 2 144 participants

Sleep Healthy Using the Internet Mitigating Insomnia to Address Neurocognitive Difficulties (SHUTi MIND)

University of Virginia

NCT05565833

RECRUITING 80 participants

SQUED™ Series 28.1 Home-use and Treatment of Autowave Reverberator of Autism

American Federation of Medical Synergetics

NCT03222375

RECRUITING NA 76 participants

Brain Connections for Arm Movement After Stroke

VA Office of Research and Development

NCT04286516

RECRUITING NA 12 participants

Spinal Cord Transcutaneous Stimulation Effect on Blood Pressure in Acute Spinal Cord Injury (SCI)

Kessler Foundation

NCT05731986

RECRUITING NA 10 participants

Deep Brain Stimulation Motor Ventral Thalamus (VOP/VIM) for Restoration of Speech and Upper-limb Function in People With Subcortical Stroke

Jorge Gonzalez-Martinez

NCT06303869

RECRUITING NA 5 participants

The Effect of Transcutaneous Stimulation on Blood Pressure in Spinal Cord Injury (SCI)

Kessler Foundation

NCT05725499

ACTIVE NOT RECRUITING Phase 3 1,175 participants

A Study of Different Donanemab (LY3002813) Dosing Regimens in Adults With Early Alzheimer's Disease (TRAILBLAZER-ALZ 6)

Eli Lilly and Company

NCT05738486

ACTIVE NOT RECRUITING Phase 3 106 participants

A Study of Deramiocel (CAP-1002) in Ambulatory and Non-Ambulatory Patients With Duchenne Muscular Dystrophy

Capricor

NCT05126758

ACTIVE NOT RECRUITING NA 90 participants

Tai Chi Effects on Chronic Insomnia in Breast Cancer Survivors: Immune Mechanisms

Jonsson Comprehensive Cancer Center

NCT00690196

COMPLETED 450 participants

Safety Follow-up Study for Subjects With Agitation Associated With Dementia of the Alzheimer's Type Who Previously Participated in a Double-blind Trial of Brexpiprazole or Placebo

Otsuka Pharmaceutical Development & Commercialization

NCT02192554

COMPLETED Phase 3 433 participants

A Phase 3, 12-week, Multicenter, Randomized, Double-blind, Placebo-controlled Trial to Evaluate the Efficacy, Safety, and Tolerability of 2 Fixed Doses of Brexpiprazole in the Treatment of Alzheimer's Agitation

Otsuka Pharmaceutical Development & Commercialization

NCT01862640

COMPLETED NA 340 participants

pRESET for Occlusive Stroke Treatment

phenox

NCT03994822

COMPLETED 300 participants

Genotype/Phenotype Correlation of Movement Disorders and Other Neurological Diseases

National Institute of Neurological Disorders and Stroke (NINDS)

NCT00001667

COMPLETED Phase 3 270 participants

Safety and Tolerability Study of Flexible Dosing of Brexpiprazole in the Treatment of Subjects With Agitation Associated With Dementia of the Alzheimer's Type

Otsuka Pharmaceutical Development & Commercialization

NCT01922258

COMPLETED NA 90 participants

Dietary Supplements for the Treatment of Angelman Syndrome

University of California, San Diego

NCT00348933

COMPLETED NA 80 participants

Harmony at Home: A Pilot Telehealth Program for Rural ADRD Caregivers

Elizabeth K Rhodus

NCT05202223

COMPLETED 62 participants

StimRouter Registry Clinical Protocol

Bioness

NCT03913689

COMPLETED 60 participants

Validity and Inter-Rater Reliability of a Novel Bedside Referral Tool for Spasticity

Vanderbilt University Medical Center

NCT03209960

COMPLETED 60 participants

Using Telemedicine to Improve Spasticity Diagnosis Rates

Vanderbilt University Medical Center

NCT03211390

COMPLETED 48 participants

Humoral and T-Cell Responses to COVID-19 Vaccination in Multiple Sclerosis Patients Treated With Ocrelizumab Treated With Ocrelizumab or Natalizumab

Dragonfly Research

NCT04837651

COMPLETED Phase 2 37 participants

Extension of AOC 1001-CS1 (MARINA) Study in Adult Myotonic Dystrophy Type 1 (DM1) Patients

Avidity Biosciences

NCT05479981

COMPLETED Phase 1 19 participants

Study of Pioglitazone in Sporadic Inclusion Body Myositis

Johns Hopkins University

NCT03440034

Phase Distribution

PhaseTrial count
Phase 1 1
Phase 2 2
Phase 3 4

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Nervous System Diseases Trial Landscape

ClinicalTrials.gov lists 24 US studies indexed under Nervous System Diseases, and 8 of those are currently open to recruitment — roughly 33% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

The phase distribution for Nervous System Diseases shows 4 late-stage studies (Phase 3 and Phase 4 combined) alongside 3 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

Top sponsor activity for Nervous System Diseases is led by Otsuka Pharmaceutical Development & Commercialization with 3 indexed trials, alongside 9 other organizations in the top contributor list. The list on this page surfaces up to 24 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Nervous System Diseases?

PlainTrial tracks 24 US clinical trials for Nervous System Diseases, of which 8 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Nervous System Diseases?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Related

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

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