Mayo Clinic

Open enrollment with an early-phase pipeline tilt

According to ClinicalTrials.gov-derived indexes, Mayo Clinic sits in the top decile of US sponsors by registered trial count (#2 of 15,742 sponsors by registered trial count).

2,844 total trials 544 currently recruiting 1816 completed early-phase tilt top decile by trial count

Mayo Clinic: 2,844 sponsored US clinical trials, 544 recruiting.

Mayo Clinic sponsors 2,844 registered US clinical trials on ClinicalTrials.gov, 544 of them currently recruiting, and 1,816 completed. 252 of these trials are in Phase 3-4 (later-stage) and 821 in Phase 1-2 (earlier-stage). The most-studied condition in this pipeline is Healthy, with 36 trials.

Top-decile sponsor footprint

Mayo Clinic ranks in the top decile of sponsors by registered trial count (#2 of 15,742 sponsors by registered trial count). Volume at this scale usually reflects a long institutional pipeline, read phase tilt and therapeutic areas below before treating it as current-year activity.

Trial completion reliability score

D 56/100

1,816 of 2,102 decided trials (Completed vs. Terminated on ClinicalTrials.gov) reached their planned completion (86.4%), vs. national p10 68.4% / p90 100% among 1,234 sponsors with at least 10 decided trials. Still-open trials (Recruiting, Active-not-recruiting, Not-yet-recruiting) are excluded since they have not reached an outcome yet.

Open and recent trials

2,844 total, page 46 of 57

COMPLETED NA

Improving Maintenance Following Very Low Calorie Diet: The Sustain Lost Weight (SLW) Intervention

NCT01222988

COMPLETED Phase 1

Assessment of Coronary Plaque Composition Using Optical Coherence Tomography

NCT01642173

COMPLETED

Non-Invasive EndoPAT Increases Diagnostic Yield of CAD by Coronary Angiography

NCT01581671

COMPLETED NA

A Psychological and Behavioral Intervention for Post-Bariatric Patients

NCT01453517

COMPLETED Phase 1

Tobacco Cessation Treatment for Alaska Native Youth

NCT01099384

COMPLETED NA

Multicomponent Intervention to Decrease Chronic Obstructive Pulmonary Disease (COPD)-Related Hospitalizations

NCT01058486

COMPLETED Phase 1

Acetaminophen Transfer Across the Placenta and the Assessment of Fetal Well-being

NCT01211912

COMPLETED Phase 1

Efficacy of Albuterol in the Treatment of Congenital Myasthenic Syndromes

NCT01203592

COMPLETED Phase 1

Decision Aid Development for Smokers

NCT01193972

COMPLETED NA

Short-Term Fasting Before Chemotherapy in Treating Patients With Cancer

NCT01175837

COMPLETED NA

Integrated Behavioral Intervention for Cigarette Smoking and Binge Drinking in Young Adults

NCT01184261

COMPLETED

Endoscopic Submucosal Dissection Registry

NCT01415609

COMPLETED NA

Endoscopic Quality Improvement Program

NCT01415817

COMPLETED

Validation Study of the Patient-Reported Outcomes Version of the Common Terminology Criteria for Adverse Events (PRO-CTCAE)

NCT02158637

COMPLETED

Hepatitis B and Hepatitis C as Risk Factors for Hepatocellular Carcinoma in African and Asian Immigrants

NCT02366286

COMPLETED Early Phase 1

Fluorine F 18 Fluorodopa-Labeled PET Scan in Planning Surgery and Radiation Therapy in Treating Patients With Newly Diagnosed High- or Low-Grade Malignant Glioma

NCT01165632

COMPLETED Phase 2

Highdose Nicotine Patch Therapy for Smokeless Tobacco Use

NCT00939029

COMPLETED NA

Potential Impact of Polycystic Ovarian Syndrome on Protein Modifications and Accumulation

NCT02105428

COMPLETED

Biomarkers in Aortic Stenosis - B.A.S.S.

NCT01334801

COMPLETED NA

Prospective Study of Undiagnosed Celiac Disease

NCT01317914

TERMINATED NA

Ultrasound Image Fusion for Placement of Sacral Quadripolar Leads

NCT01054534

COMPLETED Phase 2

Trial Evaluating the Effect of Facilitated Small Group Sessions on Physician Well-Being, Job Satisfaction, and Professionalism

NCT01159977

COMPLETED Phase 1

Influence of Male Hormones on Regional Fat Metabolism

NCT01160328

COMPLETED

Early Increase in Blood Supply in Patients With Barrett's Esophagus

NCT01188980

COMPLETED NA

Early Increase in Blood Flow (EIBS) in the Duodenum in Patients With Pancreatic Cancer

NCT01015820

COMPLETED Phase 1

Mesenchymal Stem Cells for Treatment of Amyotrophic Lateral Sclerosis (ALS)

NCT01142856

COMPLETED Phase 2

Rapid Easy Strength Training (REST) to Improve Function in Late Stage Cancer

NCT01334983

COMPLETED NA

Wait-list Study of One-Week Intensive Cognitive-Behavioral Therapy for Pediatric Obsessive-Compulsive Disorder (OCD)

NCT01194076

COMPLETED Phase 4

Tricuspid Regurgitation Study

NCT01093001

COMPLETED Phase 2

A Pilot Study of Hemin Therapy for Gastroparesis (Diabetes Mellitus)

NCT01206582

COMPLETED Phase 1

Oxazyme in Patients With Hyperoxaluria

NCT01127087

TERMINATED Phase 1

Eculizumab to Prevent Antibody-mediated Rejection in ABO Blood Group Incompatible Living Donor Kidney Transplantation

NCT01095887

COMPLETED Phase 4

The FIRSTT: Comparing MRgFUS(MR-guided Focused Ultrasound) Versus UAE (Uterine Artery Embolization)for Uterine Fibroids.

NCT00995878

COMPLETED Phase 1

Assessment of Combined Bowel Preparation for Capsule Endoscopy Study

NCT01243736

COMPLETED

Finger Hardness Measure in Scleroderma

NCT01111786

COMPLETED

Pilot to Assess DBE as a Rescue Technique for Failed PEJ

NCT01057940

COMPLETED Phase 1

Intestinal Microecology in Chronic Constipation

NCT00934479

COMPLETED NA

Impact of Decision Aids to Enhance Shared Decision Making for Diabetes

NCT01029288

TERMINATED NA

Study of Repetitive Transcranial Magnetic Stimulation (rTMS) as Adjuvant Treatment for Depression

NCT01115699

COMPLETED NA

Trendelenburg's Slide Prevention Study

NCT01068821

COMPLETED

Fat Biology, Sleep Disorders, and Cardiovascular Disease

NCT01229501

COMPLETED NA

Feasibility of Translumenal Endoscopic Omental Patch Closure of Perforated Viscus

NCT01080326

COMPLETED NA

Evaluating Transcutaneous Electrical Nerve Stimulation for Postoperative Pain After Video-Assisted Thoracotomy Surgery

NCT01046695

COMPLETED Phase 2

A Placebo-Controlled Trial of Pregabalin (Lyrica) for Irritable Bowel Syndrome

NCT00977197

COMPLETED Phase 1

Cyclophosphamide, Carfilzomib, Thalidomide, and Dexamethasone in Treating Patients With Newly Diagnosed Active Multiple Myeloma

NCT01057225

COMPLETED Phase 4

Does Intensive Acid Suppression Reduce Esophageal Inflammation and Recurrent Barrett's Esophagus Following Ablation?

NCT01093755

COMPLETED Phase 4

Pregabalin and Colonic Function

NCT01094808

COMPLETED

Use of Low-dose Molecular Breast Imaging for the Detection of Small Breast Lesions

NCT01285440

COMPLETED Phase 2

Ofatumumab, Pentostatin, and Cyclophosphamide in Treating Patients With Untreated Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma

NCT01024010

COMPLETED Phase 1

PiB PET Scanning in Speech and Language Based Dementias

NCT01623284

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Phase Distribution

PhaseTrial count
Phase 1 435
Phase 2 386
Phase 3 86
Phase 4 166

What is open in the Mayo Clinic pipeline

544 recruiting of 2,844 indexed (19% open); 1,816 completed (64%).

Phase mix: 252 late (III/IV) vs 821 early (I/II) (early-phase heavy).

Top condition: Healthy (36 trials), 9 others listed.

How open-pipeline share is computed

Recruiting share is recruiting_count divided by trial_count for this sponsor in the public registry export. Status can change between pulls; treat the figure as a research-attention snapshot, not product availability.

Mayo Clinic: open-pipeline peers nationwide

Peers matched on 2,844 registered trials and 19% open enrollment, not the therapeutic-area sidebar.

Mayo Clinic sits at or above the median trial volume and at or above the median recruiting share among these 9 nationwide peers -- the two do not always move together. Source: ClinicalTrials.gov (2026-08-08 snapshot). 2×2 strategic matrix plotting 9 entities by Total trials (X) and Recruiting share (Y), with a crosshair dividing the plot into four quadrants. Higher volume & more openFocused & more openHigher volume, mostly closedSmaller & mostly closed 01,0002,0003,0004,000 5%10%15%20%25% Total trials Recruiting share Mayo ClinicM.D. Anderson Cancer CenterNational Cancer Institute (NCI)Massachusetts General HospitalNational Institute of Allergy and Infectious Diseases (NIAID)University of South CarolinaVanderbilt University Medical CenterMemorialCare Health SystemUniversity of North Texas Health Science Center
Mayo Clinic sits at or above the median trial volume and at or above the median recruiting share among these 9 nationwide peers -- the two do not always move together. Source: ClinicalTrials.gov (2026-08-08 snapshot).

Mayo Clinic sits at or above the median trial volume and at or above the median recruiting share among these 9 nationwide peers -- the two do not always move together.

Sponsors near 2,844 trials (± recruiting share)

Sponsors near 19% open enrollment (± trial volume)

What to do with this Mayo Clinic page

2,844 registered trials is a research-attention snapshot, not an endorsement of Mayo Clinic or any single study.

  • 544 of Mayo Clinic's trials are currently recruiting, check each one's own eligibility criteria before contacting a site. Browse recruiting trials
  • Healthy is the condition Mayo Clinic studies most, compare against other sponsors active in the same condition before evaluating a specific study. See Healthy trials
  • Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide

Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. Mayo Clinic pipeline card: 2,844 registered trials from official public datasets. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.