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NCT02105428 · ClinicalTrials.gov registry record · NA
Potential Impact of Polycystic Ovarian Syndrome on Protein Modifications and Accumulation
A NA study, sponsored by Mayo Clinic.
- Completed
- Registry status
- NA
- Development phase
- 44
- Enrollment target
NCT02105428: Completed NA study, sponsored by Mayo Clinic.
NCT02105428 is a NA study that has completed, run by Mayo Clinic. The registered enrollment target is 44 participants. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT02105428, a NA study, has completed, sponsored by Mayo Clinic.
- COMPLETED
- Registry status
- NA
- Development phase
- 44 participants
- Enrollment target
Study Summary
A goal of this study is to use a novel methodology to determine whether insulin resistance in women with polycystic ovary syndrome (PCOS) is related to the accumulation of proteins with modifications. This could lead to future research to determine if these modifications interfere with their proper function. Additionally, the investigators will determine how protein quality is affected by exercise training. Aerobic exercise enhances the endogenous oxidant buffering systems which may minimize oxidative damage to proteins. The investigators propose that aerobic exercise minimizes the accrual of modified proteins by increasing the synthesis of new proteins, but also by increasing the degradation and removal of old and damaged proteins. Based on our previous studies the investigators observed that insulin affects plasma protein synthesis and aerobic exercise improves insulin sensitivity not only in muscle but also in liver. The investigators therefore propose that aerobic exercise and related increase in insulin sensitivity (and decline in insulin levels) will reduce accumulation of old and modified skeletal muscle and plasma proteins leading to improved function.
Interventions
- BEHAVIORAL Aerobic Exercise Training
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 44 participants |
| Start Date | 2010-07 |
| Est. Completion | 2015-12 |
| Phase | NA |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT02105428
The ClinicalTrials.gov registry entry for NCT02105428 describes a study currently listed as completed, categorized as NA. The registered enrollment target is 44 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Mayo Clinic, which has 2,844 total studies on file at ClinicalTrials.gov.
The record links to 0 conditions, and to 1 intervention - of which Aerobic Exercise Training is the first listed.
NCT02105428 reports 0 study locations.
Frequently Asked Questions
What is clinical trial NCT02105428 about?
NCT02105428 is a clinical study titled "Potential Impact of Polycystic Ovarian Syndrome on Protein Modifications and Accumulation". A goal of this study is to use a novel methodology to determine whether insulin resistance in women with polycystic ovary syndrome (PCOS) is related to the accumulation of proteins with modifications. This could lead to future research to determine if these modifications interfere with their proper ...
What is the current status of trial NCT02105428?
This trial is currently completed. It is a NA study. The enrollment target is 44 participants. The study started on 2010-07. Estimated completion is 2015-12.
What interventions are being tested in trial NCT02105428?
The interventions under investigation include: Aerobic Exercise Training (BEHAVIORAL).
Who is sponsoring clinical trial NCT02105428?
This trial is sponsored by Mayo Clinic, which has 2,844 total clinical trials registered on ClinicalTrials.gov.
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