Massachusetts General Hospital

Open enrollment with an early-phase pipeline tilt

According to ClinicalTrials.gov-derived indexes, Massachusetts General Hospital sits in the top decile of US sponsors by registered trial count (#4 of 15,751 sponsors by registered trial count).

2,032 total trials 336 currently recruiting 1284 completed early-phase tilt top decile by trial count

Massachusetts General Hospital: 2,032 sponsored US clinical trials, 336 recruiting.

Massachusetts General Hospital sponsors 2,032 registered US clinical trials on ClinicalTrials.gov, 336 of them currently recruiting, and 1,284 completed. 240 of these trials are in Phase 3-4 (later-stage) and 515 in Phase 1-2 (earlier-stage). The most-studied condition in this pipeline is Depression, with 29 trials.

Top-decile sponsor footprint

Massachusetts General Hospital ranks in the top decile of sponsors by registered trial count (#4 of 15,751 sponsors by registered trial count). Volume at this scale usually reflects a long institutional pipeline, read phase tilt and therapeutic areas below before treating it as current-year activity.

Open and recent trials

2,032 total, page 34 of 41

TERMINATED Phase 2

Study to Investigate the Safety and Efficacy of Lithium in Volunteers With Amyotrophic Lateral Sclerosis (ALS)

NCT00818389

COMPLETED

Pilot Study to Evaluate Optical Frequency Domain Imaging for Diagnosis of Central Airway Disease

NCT01396603

COMPLETED NA

Zolpidem CR and Hospitalized Patients With Dementia

NCT00814502

COMPLETED

Escitalopram Neuroimaging Supplement

NCT01398865

COMPLETED

Developing A Validated Measure of the Impact of Psoriasis on Chronic Quality of Life

NCT00823914

COMPLETED Phase 4

Effect of Vyvanse on Driving in Young Adults With ADHD

NCT00801229

COMPLETED

Bilicurves: Using Information Technology to Improve the Management of Neonatal Hyperbilirubinemia

NCT00801619

COMPLETED Phase 1

Cognitive Behavioral Therapy for Trichotillomania

NCT00740909

COMPLETED NA

Mallet Finger Splinting Study

NCT01388751

COMPLETED Early Phase 1

D-Cycloserine Augmentation of Behavior Therapy for Individuals With Body Dysmorphic Disorder

NCT00842309

COMPLETED NA

Omega-3 for Peri- and Postmenopausal Depression

NCT00825994

COMPLETED NA

Cognitive-Behavioral Therapy (CBT) in Women Discontinuing Antidepressant for Pregnancy

NCT01453114

TERMINATED Phase 1

Intentional Rejection of the Donor Graft Using Recipient Leukocyte Infusion(s) Following Nonmyeloablative Allogeneic Stem Cell Transplant

NCT00909948

TERMINATED Phase 1

Natural Orifice Translumenal Endoscopic Surgery: Laparoscopic-Assisted Transvaginal Cholecystectomy

NCT00910325

TERMINATED NA

Validation of Mixed Venous Blood Oxygen Saturation Obtained With a Novel Mathematical Equation

NCT00783952

TERMINATED NA

Proportional Assist Ventilation vs Pressure Support Ventilation

NCT00790725

COMPLETED

Autism Spectrum Disorders (ASD) Characterization Study

NCT00801554

COMPLETED NA

Optical Frequency Domain Imaging (OFDI) Assessment in Radiofrequency Ablation

NCT01439594

COMPLETED Phase 1

Vandetanib and Sirolimus in Patients With Recurrent Glioblastoma

NCT00821080

COMPLETED Phase 1

Effectiveness of Antiretroviral Therapy During Acute HIV Infection

NCT00705926

TERMINATED Phase 2

A Study to Examine the Safety and Efficacy of Drospirenone and Ethinyl Estradiol (YAZ) Versus Placebo In HS

NCT00722800

TERMINATED

Long-term Cardiovascular Risk in Cured Cushing's Patients

NCT00881283

COMPLETED

Understanding Gastrointestinal Conditions in Children With Autism Spectrum Disorder (ASD)

NCT01675414

COMPLETED

The CASABLANCA Study: Catheter Sampled Blood Archive in Cardiovascular Diseases

NCT00842868

COMPLETED Phase 3

A Double-Blind, Placebo-Controlled Study of Aripiprazole Adjunctive to Antidepressant Therapy

NCT00683852

COMPLETED NA

Therapy Targeting Depression and HIV Treatment Adherence (The TRIAD Study)

NCT00951028

COMPLETED NA

Internet-Based Depression Screening for College Students

NCT01326793

COMPLETED NA

Effect of Ketamine on Opioid-Induced Hyperalgesia

NCT00833755

COMPLETED Phase 2

The Role of Parathyroid Hormone (PTH) in Low Bone Mass in Anorexia Nervosa

NCT00759772

TERMINATED Phase 4

Seroquel Alone Versus Seroquel With an SSRI for Depression With Psychotic Symptoms

NCT00955474

TERMINATED NA

Clinical Management of Neuropathic Pain With Ramelteon

NCT00753623

TERMINATED Phase 2

Avastin (Bevacizumab) Plus Adriamycin, Bleomycin, Vinblastine and Dacarbazine (ABVD) for Advanced Stage Hodgkin Lymphoma

NCT00722865

TERMINATED NA

Rehabilitation With or Without Static Progressive Splinting for Wrist Stiffness

NCT01618227

COMPLETED NA

Neural Correlates of Psychodynamic Psychotherapy for Depression

NCT00812227

COMPLETED Phase 1

Fentanyl Administered Intraorally for Rapid Treatment of Orthopedic Pain

NCT00685295

TERMINATED

In Vivo Imaging of Pigmentary Disorders by Reflectance Confocal Microscopy

NCT00771355

COMPLETED Phase 2

Ziprasidone Augmentation of SSRIs for Patients With Major Depressive Disorder (MDD) That do Not Sufficiently Respond to Treatment With SSRIs

NCT00633399

COMPLETED Phase 2

Open Label Extension Assessing the Tolerability of BCI-024 in Combination With BCI-049 in Patients With Major Depressive Disorder (MDD)

NCT00731653

COMPLETED Phase 2

Effectiveness of Growth Hormone Releasing Hormone in Reducing Abdominal Fat in People Who Are Obese

NCT00675506

COMPLETED Phase 2

Effects of rhIGF-1 on Bone Metabolism in Adolescent Girls With Anorexia Nervosa

NCT00720122

COMPLETED Phase 4

Quantitative Electroencephalogram (QEEG) Predictors of Response to Psychotherapy Versus Antidepressant Treatment in Depression

NCT00824044

COMPLETED Phase 4

Pre-Operative Staging of Pancreatic Cancer Using Superparamagnetic Iron Oxide Magnetic Resonance Imaging (SPIO MRI)

NCT00920023

COMPLETED NA

The Right Question Project-Mental Health: An Intervention to Increase Engagement and Retention in Mental Health Care

NCT01226329

COMPLETED NA

A Pilot Study of Using Video Images in Advance Care Planning in Malignant Glioma Patients

NCT00970788

TERMINATED NA

MRI Scans in Evaluating the Effects of Radiation Therapy and Chemotherapy in Patients With Newly Diagnosed Glioblastoma Multiforme or Anaplastic Glioma

NCT00756106

COMPLETED Phase 1

Oral Clofarabine for Relapsed/Refractory Non-Hodgkin Lymphoma

NCT00644189

COMPLETED NA

Hypoxia-positron Emission Tomography (PET) and Intensity Modulated Proton Therapy (IMPT) Dose Painting in Patients With Chordomas

NCT00713037

COMPLETED NA

Continuous Glucose Monitoring With a Subcutaneous Sensor During Critical Illness and Surgery

NCT00694473

COMPLETED Phase 1

Vaccination With Lethally Irradiated Glioma Cells Mixed With GM-K562 Cells in Patients Undergoing Craniotomy For Recurrent Tumor

NCT00694330

COMPLETED NA

The Role of a Virtual Coach in Improving Adherence to an Activity Program for Overweight Adults

NCT00792207

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Phase Distribution

PhaseTrial count
Phase 1 226
Phase 2 289
Phase 3 58
Phase 4 182

What is open in the Massachusetts General Hospital pipeline

336 recruiting of 2,032 indexed (17% open); 1,284 completed (63%).

Phase mix: 240 late (III/IV) vs 515 early (I/II) (early-phase heavy).

Top condition: Depression (29 trials), 9 others listed.

How open-pipeline share is computed

Recruiting share is recruiting_count divided by trial_count for this sponsor in the public registry export. Status can change between pulls; treat the figure as a research-attention snapshot, not product availability.

Data sourced from official public datasets. See our methodology for details. Retrieved and formatted by PlainTrial

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial from this sponsor, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.