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NCT00955474 · ClinicalTrials.gov registry record · Phase 4
Seroquel Alone Versus Seroquel With an SSRI for Depression With Psychotic Symptoms
A Phase 4 study, sponsored by Massachusetts General Hospital.
- Terminated
- Registry status
- Phase 4
- Development phase
- 32
- Enrollment target
NCT00955474: Clinical Trial Phase 4 study, sponsored by Massachusetts General Hospital.
NCT00955474 is a Phase 4 study that was terminated before completion, run by Massachusetts General Hospital. The registered enrollment target is 32 participants, below the 518-participant average among 9,235 other Phase 4 trials with a reported enrollment target (94% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT00955474, a Phase 4 study, was terminated before completion, sponsored by Massachusetts General Hospital.
- TERMINATED
- Registry status
- Phase 4
- Development phase
- 32 participants
- Enrollment target
Study Summary
The purpose of this study is to compare the efficacy and tolerability of Seroquel monotherapy for the treatment of Major Depression with Psychotic features with Seroquel plus Selective Serotonin Reuptake Inhibitor.
Primary Outcome
Depression measured with Hamilton Rating Scale for Depression 17 (HAM-D) at baseline and 8 weeks. Ham D 17 scores range from 0-52, 52 being the most severe.
Interventions
- DRUG Quetiapine
- DRUG Sertraline
- DRUG Citalopram
- DRUG escitalopram
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 32 participants |
| Start Date | 2008-09 |
| Est. Completion | 2013-01 |
| Phase | Phase 4 |
Why NCT00955474 stopped before completion
NCT00955474 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 32 participants, a relatively small participant target, below the 518-participant average among 9,235 other Phase 4 trials with a reported enrollment target (94% lower).
The record links to 0 conditions, and to 4 interventions - of which Quetiapine is the first listed.
NCT00955474 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT00955474 about?
NCT00955474 is a clinical study titled "Seroquel Alone Versus Seroquel With an SSRI for Depression With Psychotic Symptoms". The purpose of this study is to compare the efficacy and tolerability of Seroquel monotherapy for the treatment of Major Depression with Psychotic features with Seroquel plus Selective Serotonin Reuptake Inhibitor.
What is the current status of trial NCT00955474?
This trial is currently terminated. It is a Phase 4 study. The enrollment target is 32 participants. The study started on 2008-09. Estimated completion is 2013-01.
What interventions are being tested in trial NCT00955474?
The interventions under investigation include: Quetiapine (DRUG), Sertraline (DRUG), Citalopram (DRUG), escitalopram (DRUG).
Who is sponsoring clinical trial NCT00955474?
This trial is sponsored by Massachusetts General Hospital, which has 2,032 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT00955474's enrollment target sits among peer trials
32 1534th of 2000 higher than 457 of 2,000 other Phase 4 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 4 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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