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ClinicalTrials.gov 4 recruiting now official registry

Stage IV Non-small Cell Lung Cancer clinical trials

4 of 24 indexed Stage IV Non-small Cell Lung Cancer trials are currently recruiting.

24 US clinical trials · 4 currently recruiting

Stage IV Non-small Cell Lung Cancer is the subject of 24 registered US clinical trials on ClinicalTrials.gov, 4 of them currently open to new participants. 0 are in Phase 3-4 (later-stage) and 19 in Phase 1-2 (earlier-stage). The most active sponsor is National Cancer Institute (NCI), running 9 of these trials.

The research picture

Stage IV Non-small Cell Lung Cancer has 24 registered US clinical trials, 4 of them open to new participants right now, about 17% of the total.

4
recruiting participants now
17%
of trials open to enrollment
0
in Phase 3–4 (later-stage)
9
top sponsor: National Cancer Institute (NCI)
Phase 19Phase 210

Active & Recent Trials

24 total, page 1 of 1

RECRUITING NA 3,584 participants

Beating Lung Cancer in Ohio Protocol in Improving Survival in Patients With Stage IV Non-Small Cell Lung Cancer

Ohio State University Comprehensive Cancer Center

NCT03199651

RECRUITING NA 1,020 participants

Comprehensive Genomic Analysis in Tissue Samples From Patients With Recurrent or Stage IV Non-small Cell Lung Cancer

Barbara Ann Karmanos Cancer Institute

NCT02178163

RECRUITING NA 70 participants

Patient-centered, Optimal Integration of Survivorship and Palliative Care

Massachusetts General Hospital

NCT04900935

RECRUITING Phase 1 53 participants

A Study to Investigate the Efficacy and Safety of an Infusion of IOV-4001 in Adult Participants With Unresectable or Metastatic Melanoma or Stage III or IV Non-small-cell Lung Cancer

Iovance Biotherapeutics

NCT05361174

ACTIVE NOT RECRUITING 10,000 participants

Predicting Responsiveness in Oncology Patients Based on Host Response Evaluation During Anti Cancer Treatments

OncoHost

NCT04056247

ACTIVE NOT RECRUITING Phase 2 218 participants

Maintenance Chemotherapy With or Without Local Consolidative Therapy in Treating Patients With Stage IV Non-small Cell Lung Cancer

NRG Oncology

NCT03137771

ACTIVE NOT RECRUITING Phase 2 174 participants

S1403, Afatinib Dimaleate With or Without Cetuximab in Treating Patients With Newly Diagnosed Stage IV or Recurrent, EGFR Mutation Positive Non-small Cell Lung Cancer

SWOG Cancer Research Network

NCT02438722

ACTIVE NOT RECRUITING Phase 1 21 participants

Ceritinib Plus Docetaxel in ALK-Negative, EGFR WT Advanced NSCLC

H. Lee Moffitt Cancer Center and Research Institute

NCT03611738

ACTIVE NOT RECRUITING Phase 1 13 participants

Clinical Trial of CD40L-Augmented TIL for Patients With EGFR, ALK, ROS1 or HER2-Driven NSCLC

H. Lee Moffitt Cancer Center and Research Institute

NCT05681780

ACTIVE NOT RECRUITING Early Phase 1 10 participants

Ruxolitinib for Cancer Cachexia

Tu Dan

NCT04906746

COMPLETED NA 129 participants

Erlotinib in Treating Patients With Stage IIIB, Stage IV, or Recurrent Non-Small Cell Lung Cancer

National Cancer Institute (NCI)

NCT00085280

COMPLETED Phase 1 94 participants

Azacitidine and Entinostat in Treating Patients With Recurrent Advanced Non-Small Cell Lung Cancer

National Cancer Institute (NCI)

NCT00387465

COMPLETED Phase 2 80 participants

Erlotinib and Celecoxib in Treating Patients With Stage IIIB or Stage IV Recurrent Non-Small Cell Lung Cancer

National Cancer Institute (NCI)

NCT00062101

COMPLETED Phase 2 65 participants

S0341: Erlotinib in Treating Patients With Advanced Primary Non-Small Cell Lung Cancer

National Cancer Institute (NCI)

NCT00087412

COMPLETED Phase 2 60 participants

Effects of Carboplatin and Gemcitabine on Stage IIIB Pleural Effusion and Stage IV Lung Cancer

Susanne Arnold

NCT00247416

COMPLETED Phase 2 50 participants

CCI-779 in Treating Patients With Stage IIIB (With Pleural Effusion) or Stage IV Non-Small Cell Lung Cancer

National Cancer Institute (NCI)

NCT00079235

COMPLETED Phase 2 48 participants

Tipifarnib, Gemcitabine, and Cisplatin in Treating Patients With Stage III or Stage IV Non-Small Cell Lung Cancer

National Cancer Institute (NCI)

NCT00055757

COMPLETED Phase 2 43 participants

Effect of Pembrolizumab With or Without Carboplatin and Paclitaxel on Immune Response in Patients With Recurrent or Stage IIIB-IV Non-small Cell Lung Cancer

Wake Forest University Health Sciences

NCT02581943

COMPLETED Phase 2 42 participants

Bortezomib in Treating Patients With Stage IIIB or Stage IV Lung Cancer

National Cancer Institute (NCI)

NCT00118144

COMPLETED Phase 1 34 participants

Bortezomib Plus Gemcitabine and Carboplatin in Treating Patients With Advanced or Recurrent Non-Small Cell Lung Cancer

National Cancer Institute (NCI)

NCT00052338

COMPLETED Phase 1 18 participants

Erlotinib Hydrochloride With or Without Cixutumumab in Treating Patients With Stage III or Stage IV Non-Small Cell Lung Cancer

National Cancer Institute (NCI)

NCT00778167

COMPLETED Phase 2 13 participants

Pembrolizumab Alone or Sequentially Following Single Fraction Non-ablative Radiation to One of the Target Lesions, in Previously Treated Patients With Stage IV NSCLC

Case Comprehensive Cancer Center

NCT02658097

COMPLETED Early Phase 1 10 participants

Stereotactic Body Radiation Therapy After Surgery in Treating Patients With Stage III-IV Non-small Cell Lung Cancer

Roswell Park Cancer Institute

NCT01781741

COMPLETED Phase 1 8 participants

Exemestane, Pemetrexed Disodium, and Carboplatin in Treating Post-Menopausal Women With Stage IV Non-Small Cell Lung Cancer

Jonsson Comprehensive Cancer Center

NCT01664754

Phase Distribution

PhaseTrial count
Phase 1 9
Phase 2 10

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Stage IV Non-small Cell Lung Cancer Trial Landscape

24 indexed Stage IV Non-small Cell Lung Cancer studies · 4 recruiting (17%).

Phase mix: 0 late (III/IV) vs 19 early (I/II).

Top sponsor: National Cancer Institute (NCI) (9 trials), 9 others listed. 24 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Stage IV Non-small Cell Lung Cancer?

PlainTrial tracks 24 US clinical trials for Stage IV Non-small Cell Lung Cancer, of which 4 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Stage IV Non-small Cell Lung Cancer?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.