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ClinicalTrials.gov 4 recruiting now early-phase tilt small index

Stage IIIA Hepatocellular Carcinoma AJCC V8: early-phase trial registry

4 of 9 indexed Stage IIIA Hepatocellular Carcinoma AJCC V8 trials are currently recruiting, with more weight in Phase 1-2.

Corpus placement: #1,916 of 28,707 conditions by registered trial count.

9 US clinical trials · 4 currently recruiting · #1,916 of 28,707 conditions by registered trial count

Stage IIIA Hepatocellular Carcinoma AJCC V8: 9 US clinical trials tracked, 4 recruiting.

Stage IIIA Hepatocellular Carcinoma AJCC V8 is the subject of 9 registered US clinical trials on ClinicalTrials.gov, 4 of them currently open to new participants. 0 are in Phase 3-4 (later-stage) and 8 in Phase 1-2 (earlier-stage). The most active sponsor is Academic and Community Cancer Research United, running 2 of these trials.

Enrollment posture brief

Registry condition stage-iiia-hepatocellular-carcinoma-ajcc-v8

OPEN 4 | RECR 44% | LATE 0 | EARLY 8 | RANK #1916 | SPON 2

Nearest open-share peer: Acute Ischemic Stroke (44% recruiting · 27 trials)

Acute Lymphoblastic Leukemia55.6%Acute Respiratory Distress S55.6%Stage IIIA Hepatocellula (th…44%Acute Otitis Media22.2%Acute Heart Failure11.1%
Open-enrollment share among volume-matched conditions near Stage IIIA Hepatocellular Carcinoma AJCC V8

Stage IIIA Hepatocellular Carcinoma AJCC V8 lists 4 open slots (44% of 9 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →

Key findings

What ClinicalTrials.gov does not surface for Stage IIIA Hepatocellular Carcinoma AJCC V8 on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.

  1. Stage IIIA Hepatocellular Carcinoma AJCC V8 is recruiting below its size-band peers.

    4 of 9 indexed trials (44.4%) are open to enrollment, against a 46.5% average across 27,806 conditions with fewer than 20 trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.

  2. One sponsor concentrates Stage IIIA Hepatocellular Carcinoma AJCC V8 research.

    Academic and Community Cancer Research United accounts for 2 of 9 trials (22.2%). 7 distinct sponsors appear on at least one study for this condition label.

  3. Most Stage IIIA Hepatocellular Carcinoma AJCC V8 trials plan to enrol fewer than 100 people.

    Median target enrolment is 21 among the 9 trials that report a genuine target (sentinel values excluded). 8 of those (88.9%) plan for fewer than 100 participants.

  4. Stage IIIA Hepatocellular Carcinoma AJCC V8 research is mostly interventional.

    9 interventional and 0 observational studies make up this index (100% interventional). Study type is sponsor-reported on ClinicalTrials.gov.

Phase 12Phase 26

Open and recent trials

9 total, page 1 of 1

RECRUITING Phase 2 122 participants

Atezolizumab in Combination With a Multi-Kinase Inhibitor for the Treatment of Unresectable, Locally Advanced, or Metastatic Liver Cancer

Academic and Community Cancer Research United

NCT05168163

RECRUITING Phase 2 21 participants

Durvalumab With/Without Tremelimumab After Palliative Hypofractionated Radiotherapy for Hepatocellular Carcinoma

Mary Feng, MD

NCT04430452

RECRUITING Phase 2 19 participants

Lenvatinib for the Treatment of Recurrent Hepatocellular Carcinoma After Liver Transplant

Emory University

NCT05103904

RECRUITING Phase 1 15 participants

Nivolumab, Fluorouracil, and Interferon Alpha 2B for the Treatment of Unresectable Fibrolamellar Cancer

M.D. Anderson Cancer Center

NCT04380545

ACTIVE NOT RECRUITING NA 42 participants

Radioembolization for HCC Patients With Personalized Yttrium-90 Dosimetry for Curative Intent (RAPY90D)

M.D. Anderson Cancer Center

NCT03896646

ACTIVE NOT RECRUITING Phase 2 40 participants

Testing the Combination of Pevonedistat With Chemotherapy for Bile Duct Cancer of the Liver

National Cancer Institute (NCI)

NCT04175912

ACTIVE NOT RECRUITING Phase 1 25 participants

Durvalumab and Tremelimumab After Radioembolization for the Treatment of Unresectable, Locally Advanced Liver Cancer

City of Hope Medical Center

NCT04605731

ACTIVE NOT RECRUITING Phase 2 4 participants

Regorafenib and Durvalumab for the Treatment of High-Risk Liver Cancer

Academic and Community Cancer Research United

NCT05194293

COMPLETED Phase 2 16 participants

Sorafenib and Nivolumab in Treating Participants With Unresectable, Locally Advanced or Metastatic Liver Cancer

Robin Kate Kelley

NCT03439891

Phase Distribution

PhaseTrial count
Phase 1 2
Phase 2 6

Named interventions

Most-linked intervention names on Stage IIIA Hepatocellular Carcinoma AJCC V8 records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.

Durvalumab Biological
3 trials
Tremelimumab Biological
2 trials
Lenvatinib Drug
2 trials
Nivolumab Biological
2 trials
Yttrium-90 Microsphere Radioembolization Procedure
1 trials
Yttrium Y 90 Glass Microspheres Radiation
1 trials
Hepatobiliary Iminodiacetic Acid Scan Other
1 trials
Pevonedistat Drug
1 trials

US sites by state

Facility locations filed on Stage IIIA Hepatocellular Carcinoma AJCC V8 trials. A trial with sites in several states counts in each.

California 4 trials
Arizona 3 trials
Wisconsin 2 trials
Texas 2 trials
Georgia 2 trials
Alabama 2 trials
South Dakota 1 trials
Pennsylvania 1 trials

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

What to do with this Stage IIIA Hepatocellular Carcinoma AJCC V8 page

9 registered trials, 4 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.

Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This Stage IIIA Hepatocellular Carcinoma AJCC V8 condition card totals 9 registered trials; most-linked intervention Durvalumab; top US site state California. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.