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ClinicalTrials.gov 4 recruiting now official registry

Stage IIIA Hepatocellular Carcinoma AJCC V8 clinical trials

4 of 9 indexed Stage IIIA Hepatocellular Carcinoma AJCC V8 trials are currently recruiting.

9 US clinical trials · 4 currently recruiting

Stage IIIA Hepatocellular Carcinoma AJCC V8 is the subject of 9 registered US clinical trials on ClinicalTrials.gov, 4 of them currently open to new participants. 0 are in Phase 3-4 (later-stage) and 8 in Phase 1-2 (earlier-stage). The most active sponsor is Academic and Community Cancer Research United, running 2 of these trials.

The research picture

Stage IIIA Hepatocellular Carcinoma AJCC V8 has 9 registered US clinical trials, 4 of them open to new participants right now, about 44% of the total.

4
recruiting participants now
44%
of trials open to enrollment
0
in Phase 3–4 (later-stage)
2
top sponsor: Academic and Community Cancer Research United
Phase 12Phase 26

Active & Recent Trials

9 total, page 1 of 1

RECRUITING Phase 2 122 participants

Atezolizumab in Combination With a Multi-Kinase Inhibitor for the Treatment of Unresectable, Locally Advanced, or Metastatic Liver Cancer

Academic and Community Cancer Research United

NCT05168163

RECRUITING Phase 2 21 participants

Durvalumab With/Without Tremelimumab After Palliative Hypofractionated Radiotherapy for Hepatocellular Carcinoma

Mary Feng, MD

NCT04430452

RECRUITING Phase 2 19 participants

Lenvatinib for the Treatment of Recurrent Hepatocellular Carcinoma After Liver Transplant

Emory University

NCT05103904

RECRUITING Phase 1 15 participants

Nivolumab, Fluorouracil, and Interferon Alpha 2B for the Treatment of Unresectable Fibrolamellar Cancer

M.D. Anderson Cancer Center

NCT04380545

ACTIVE NOT RECRUITING NA 42 participants

Radioembolization for HCC Patients With Personalized Yttrium-90 Dosimetry for Curative Intent (RAPY90D)

M.D. Anderson Cancer Center

NCT03896646

ACTIVE NOT RECRUITING Phase 2 40 participants

Testing the Combination of Pevonedistat With Chemotherapy for Bile Duct Cancer of the Liver

National Cancer Institute (NCI)

NCT04175912

ACTIVE NOT RECRUITING Phase 1 25 participants

Durvalumab and Tremelimumab After Radioembolization for the Treatment of Unresectable, Locally Advanced Liver Cancer

City of Hope Medical Center

NCT04605731

ACTIVE NOT RECRUITING Phase 2 4 participants

Regorafenib and Durvalumab for the Treatment of High-Risk Liver Cancer

Academic and Community Cancer Research United

NCT05194293

COMPLETED Phase 2 16 participants

Sorafenib and Nivolumab in Treating Participants With Unresectable, Locally Advanced or Metastatic Liver Cancer

Robin Kate Kelley

NCT03439891

Phase Distribution

PhaseTrial count
Phase 1 2
Phase 2 6

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Stage IIIA Hepatocellular Carcinoma AJCC V8 Trial Landscape

9 indexed Stage IIIA Hepatocellular Carcinoma AJCC V8 studies · 4 recruiting (44%).

Phase mix: 0 late (III/IV) vs 8 early (I/II).

Top sponsor: Academic and Community Cancer Research United (2 trials), 6 others listed. 9 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Stage IIIA Hepatocellular Carcinoma AJCC V8?

PlainTrial tracks 9 US clinical trials for Stage IIIA Hepatocellular Carcinoma AJCC V8, of which 4 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Stage IIIA Hepatocellular Carcinoma AJCC V8?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.