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ClinicalTrials.gov 2 recruiting now official registry

Stage III Intrahepatic Cholangiocarcinoma AJCC v8 clinical trials

Every US clinical trial registered for Stage III Intrahepatic Cholangiocarcinoma AJCC v8 — phase mix, recruiting status, and the sponsors running them, straight from the NIH ClinicalTrials.gov registry.

9 US clinical trials · 2 currently recruiting

The research picture

Stage III Intrahepatic Cholangiocarcinoma AJCC v8 has 9 registered US clinical trials, 2 of them open to new participants right now — about 22% of the total.

2
recruiting participants now
22%
of trials open to enrollment
0
in Phase 3–4 (later-stage)
3
top sponsor: National Cancer Institute (NCI)

Counts reflect the public ClinicalTrials.gov registry as last mirrored by PlainTrial. Status and phase are reported by each study's sponsor. This is reference information, not medical advice.

Active & Recent Trials

RECRUITING Phase 1 85 participants

Modified Immune Cells (Autologous Dendritic Cells) and a Vaccine (Prevnar) Combined With Immune Checkpoint Inhibition After High-Dose External Beam Radiation Therapy in Treating Patients With Unresectable Liver Cancer

Mayo Clinic

NCT03942328

RECRUITING Phase 1 16 participants

Radioembolization With Tremelimumab and Durvalumab for Locally Advanced Unresectable or Oligo-Metastatic Intrahepatic Cholangiocarcinoma

Mayo Clinic

NCT06058663

ACTIVE NOT RECRUITING Phase 2 66 participants

Study of Chemotherapy, With or Without Binimetinib in Advanced Biliary Tract Cancers in 2nd Line Setting (A ComboMATCH Treatment Trial)

National Cancer Institute (NCI)

NCT05564403

ACTIVE NOT RECRUITING Phase 2 40 participants

Testing the Combination of Pevonedistat With Chemotherapy for Bile Duct Cancer of the Liver

National Cancer Institute (NCI)

NCT04175912

ACTIVE NOT RECRUITING Phase 2 15 participants

Sacituzumab Govitecan for the Treatment for Patients With Locally Advanced, Recurrent, or Metastatic Cholangiocarcinoma

University of Kansas Medical Center

NCT06178588

ACTIVE NOT RECRUITING Phase 2 5 participants

mFOLFIRINOX Followed by Hepatic Arterial Infusion of Floxuridine and Dexamethasone With Systemic mFOLFIRI for Unresectable Liver-dominant Intrahepatic Cholangiocarcinoma

OHSU Knight Cancer Institute

NCT04251715

ACTIVE NOT RECRUITING Phase 1 2 participants

Hypofractionated Radiation Therapy and Bintrafusp Alfa for the Treatment of Advanced Intrahepatic Cholangiocarcinoma

M.D. Anderson Cancer Center

NCT04708067

COMPLETED Phase 2 86 participants

Atezolizumab With or Without Cobimetinib in Treating Patients With Metastatic Bile Duct Cancer That Cannot Be Removed by Surgery or Gallbladder Cancer

National Cancer Institute (NCI)

NCT03201458

COMPLETED Phase 2 30 participants

Gemcitabine, Cisplatin, and Nab-Paclitaxel Before Surgery in Patients With High-Risk Liver Bile Duct Cancer

Emory University

NCT03579771

Phase Distribution

PhaseTrial count
Phase 1 3
Phase 2 6

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Stage III Intrahepatic Cholangiocarcinoma AJCC v8 Trial Landscape

ClinicalTrials.gov lists 9 US studies indexed under Stage III Intrahepatic Cholangiocarcinoma AJCC v8, and 2 of those are currently open to recruitment — roughly 22% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

The phase distribution for Stage III Intrahepatic Cholangiocarcinoma AJCC v8 shows 0 late-stage studies (Phase 3 and Phase 4 combined) alongside 9 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

Top sponsor activity for Stage III Intrahepatic Cholangiocarcinoma AJCC v8 is led by National Cancer Institute (NCI) with 3 indexed trials, alongside 5 other organizations in the top contributor list. The list on this page surfaces up to 9 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Stage III Intrahepatic Cholangiocarcinoma AJCC v8?

PlainTrial tracks 9 US clinical trials for Stage III Intrahepatic Cholangiocarcinoma AJCC v8, of which 2 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Stage III Intrahepatic Cholangiocarcinoma AJCC v8?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Related

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

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