Medical Information Only. Consult your healthcare provider before considering clinical trial enrollment.

2026 data Public-data reference. official source

Stage II Prostate Cancer AJCC v8

Open-data reference.

22 US clinical trials · 12 currently recruiting

Active & Recent Trials

RECRUITING Phase 3 586 participants

Testing the Addition of the Drug Apalutamide to the Usual Hormone Therapy and Radiation Therapy After Surgery for Prostate Cancer, INNOVATE Trial

NRG Oncology

NCT04134260

RECRUITING Phase 3 240 participants

Vitamin D for Prostate Endocrine Therapy

University of Rochester

NCT05838716

RECRUITING NA 186 participants

Image-Guidance and Online Adaptation With Stereotactic Body Radiation Therapy for the Treatment of Localized Prostate Cancer, MANTICORE Trial

Jonsson Comprehensive Cancer Center

NCT07276438

RECRUITING NA 144 participants

Adaptive Radiation Therapy (ART) Stereotactic Ablative Body Radiotherapy (SABR) for Primary Localized Prostate Cancer

Mayo Clinic

NCT06325046

RECRUITING NA 100 participants

Focal Ablation With Focal Cryotherapy or HIFU for the Treatment of Men With Localized Prostate Cancer

Marc Dall'Era, MD

NCT06178354

RECRUITING NA 100 participants

MRI-guided Transurethral Urethral Ultrasound Ablation for the Treatment of Low to Intermediate Grade Prostate Cancer

Mayo Clinic

NCT05438563

RECRUITING Phase 2 95 participants

Hormone Therapy (Apalutamide) and Image-guided Stereotactic Body Radiation Therapy for the Treatment of Patients With Prostate Cancer, HEATWAVE Trial

Jonsson Comprehensive Cancer Center

NCT06067269

RECRUITING NA 80 participants

Computed Tomography-Guided Stereotactic Body Radiation Therapy With Intrafraction Motion Monitoring for the Treatment of Localized Prostate Cancer, ILLUSION Trial

Jonsson Comprehensive Cancer Center

NCT06995053

RECRUITING Phase 2 60 participants

Time-Restricted Eating Versus Nutritional Counseling for the Reduction of Radiation or Chemoradiation Tx Side Effects in Patients With Prostate, Cervical, or Rectal Cancers

City of Hope Medical Center

NCT05722288

RECRUITING NA 50 participants

Accuracy of 18F-rhPSMA-7.3 PET/ MRI for Prediction of Lymph Node Metastasis in Localized High-Risk Prostate Cancer

Mayo Clinic

NCT06389786

RECRUITING NA 25 participants

Feasibility and Effect of Wrapping Nerves With a Multi-Layer Perinatal Tissue Allograft During Prostatectomy

Mayo Clinic

NCT06940271

RECRUITING NA 20 participants

Golf Recreational Exercise for Enhanced Survivorship in Prostate Cancer Survivors

University of Southern California

NCT06500169

ACTIVE NOT RECRUITING NA 208 participants

Germline DNA-Based Radiosensitivity Biomarker Influence on Toxicity Following Prostate Radiotherapy, GARUDA Trial

Jonsson Comprehensive Cancer Center

NCT04624256

ACTIVE NOT RECRUITING 200 participants

Lifestyle Behavior Influences Among African American Patients With Stage 0-III Prostate Cancer Survivors and Their Partners

M.D. Anderson Cancer Center

NCT04189770

ACTIVE NOT RECRUITING Phase 3 186 participants

Conventional or Hypofractionated Radiation Therapy in Treating Patients With Prostate Cancer

M.D. Anderson Cancer Center

NCT03987386

ACTIVE NOT RECRUITING Phase 2 94 participants

RElugolix VErsus LeUprolide Cardiac Trial

Emory University

NCT05320406

ACTIVE NOT RECRUITING NA 64 participants

Watchful Living in Improving Quality of Life in Participants With Localized Prostate Cancer on Active Surveillance and Their Partners

M.D. Anderson Cancer Center

NCT03575832

ACTIVE NOT RECRUITING Phase 2 34 participants

Testing the Effects of Low Dose Apalutamide on Prostate-Specific Antigen (PSA) Levels in Men Scheduled for Removal of the Prostate Gland

National Cancer Institute (NCI)

NCT04530552

ACTIVE NOT RECRUITING Phase 2 14 participants

Comparison of High-Dose Rate Brachytherapy and Stereotactic Ablative Radiotherapy as Monotherapy for the Treatment of Localized Prostate Cancer

Rutgers, The State University of New Jersey

NCT04253483

ACTIVE NOT RECRUITING NA 12 participants

Neoadjuvant Dietary Intervention in Intermediate Risk Prostate Cancer

M.D. Anderson Cancer Center

NCT04985565

ACTIVE NOT RECRUITING Phase 2 12 participants

Aspirin and Rintatolimod With or Without Interferon-alpha 2b in Treating Patients With Prostate Cancer Before Surgery

Roswell Park Cancer Institute

NCT03899987

ACTIVE NOT RECRUITING NA 6 participants

Lifestyle Intervention for the Reduction of Prostate Cancer Disparities Among African Americans

M.D. Anderson Cancer Center

NCT04215029

Phase Distribution

PhaseTrial count
Phase 2 6
Phase 3 3

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Stage II Prostate Cancer AJCC v8 Trial Landscape

ClinicalTrials.gov lists 22 US studies indexed under Stage II Prostate Cancer AJCC v8, and 12 of those are currently open to recruitment — roughly 55% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

The phase distribution for Stage II Prostate Cancer AJCC v8 shows 3 late-stage studies (Phase 3 and Phase 4 combined) alongside 6 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

Top sponsor activity for Stage II Prostate Cancer AJCC v8 is led by M.D. Anderson Cancer Center with 5 indexed trials, alongside 9 other organizations in the top contributor list. The list on this page surfaces up to 22 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Stage II Prostate Cancer AJCC v8?

PlainTrial tracks 22 US clinical trials for Stage II Prostate Cancer AJCC v8, of which 12 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Stage II Prostate Cancer AJCC v8?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2024 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →