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ClinicalTrials.gov 12 recruiting now official registry

Refractory Acute Lymphoblastic Leukemia clinical trials

12 of 22 indexed Refractory Acute Lymphoblastic Leukemia trials are currently recruiting.

22 US clinical trials · 12 currently recruiting

Refractory Acute Lymphoblastic Leukemia is the subject of 22 registered US clinical trials on ClinicalTrials.gov, 12 of them currently open to new participants. 0 are in Phase 3-4 (later-stage) and 22 in Phase 1-2 (earlier-stage). The most active sponsor is M.D. Anderson Cancer Center, running 5 of these trials.

The research picture

Refractory Acute Lymphoblastic Leukemia has 22 registered US clinical trials, 12 of them open to new participants right now, about 55% of the total.

12
recruiting participants now
55%
of trials open to enrollment
0
in Phase 3–4 (later-stage)
5
top sponsor: M.D. Anderson Cancer Center
Phase 115Phase 27

Active & Recent Trials

22 total, page 1 of 1

RECRUITING Phase 1 120 participants

ONC201 in Treating Patients With Relapsed or Refractory Acute Leukemia or High-Risk Myelodysplastic Syndrome

M.D. Anderson Cancer Center

NCT02392572

RECRUITING Phase 2 90 participants

Blinatumomab, Methotrexate, Cytarabine, and Ponatinib in Treating Patients With Philadelphia Chromosome-Positive, or BCR-ABL Positive, or Relapsed/Refractory, Acute Lymphoblastic Leukemia

M.D. Anderson Cancer Center

NCT03263572

RECRUITING Phase 1 75 participants

211^At-BC8-B10 Before Donor Stem Cell Transplant in Treating Patients With High-Risk Acute Myeloid Leukemia, Acute Lymphoblastic Leukemia, Myelodysplastic Syndrome, or Mixed-Phenotype Acute Leukemia

Fred Hutchinson Cancer Center

NCT03128034

RECRUITING Phase 1 54 participants

Genetically Engineered Cells (Anti-CD19/CD20/CD22 CAR T-cells) for the Treatment of Relapsed or Refractory Lymphoid Malignancies

Sumithira Vasu

NCT05418088

RECRUITING Phase 2 42 participants

Combination Chemotherapy in Treating Patients With Relapsed or Refractory Acute Lymphoblastic Leukemia, Lymphoblastic Lymphoma, Burkitt Lymphoma/Leukemia, or Double-Hit Lymphoma/Leukemia

M.D. Anderson Cancer Center

NCT03136146

RECRUITING Phase 1 30 participants

211At-BC8-B10 Followed by Donor Stem Cell Transplant in Treating Patients With Relapsed or Refractory High-Risk Acute Leukemia or Myelodysplastic Syndrome

Fred Hutchinson Cancer Center

NCT03670966

RECRUITING Phase 2 25 participants

CAR T CELL Therapy for Pediatric, Adolescent and Young Adult Patients With CD19-Positive Leukemia

St. Jude Children's Research Hospital

NCT06847269

RECRUITING Phase 1 24 participants

Humanized CD19-Specific CAR T Cells for the Treatment of Patients With Positive Relapsed or Refractory CD19 Positive B-Cell Acute Lymphoblastic Leukemia

City of Hope Medical Center

NCT06447987

RECRUITING Phase 1 24 participants

Anti-CD19/20/22 Chimeric Antigen Receptor T Cells (TriCAR19.20.22 T Cells) for the Treatment of Relapsed or Refractory Non-Hodgkin Lymphoma, Acute Lymphoblastic Leukemia, and Chronic Lymphocytic Leukemia

Ohio State University Comprehensive Cancer Center

NCT07166419

RECRUITING Phase 1 24 participants

HA-1 T TCR T Cell Immunotherapy for the Treatment of Patients With Relapsed or Refractory Acute Leukemia After Donor Stem Cell Transplant

Fred Hutchinson Cancer Center

NCT03326921

RECRUITING Phase 1 22 participants

Palbociclib in Combination With Chemotherapy in Pediatric Patients With Relapsed or Refractory Acute Lymphoblastic Leukemia (RELPALL2)

Tanja Andrea Gruber

NCT04996160

RECRUITING Phase 1 18 participants

A Study of 19-28z/IL-18 in People With Acute Lymphoblastic Leukemia (ALL)

Memorial Sloan Kettering Cancer Center

NCT06287528

ACTIVE NOT RECRUITING Phase 2 78 participants

A Study of Revumenib in Combination With Chemotherapy for Patients Diagnosed With Relapsed or Refractory Leukemia

Children's Oncology Group

NCT05761171

ACTIVE NOT RECRUITING Phase 1 71 participants

Cellular Immunotherapy in Treating Patients With High-Risk Acute Lymphoblastic Leukemia

City of Hope Medical Center

NCT02146924

ACTIVE NOT RECRUITING Phase 2 53 participants

Blinatumomab and Combination Chemotherapy or Dasatinib, Prednisone, and Blinatumomab in Treating Older Patients With Acute Lymphoblastic Leukemia

National Cancer Institute (NCI)

NCT02143414

ACTIVE NOT RECRUITING Phase 1 36 participants

Pembrolizumab and Blinatumomab in Treating Participants With Recurrent or Refractory Acute Lymphoblastic Leukemia

City of Hope Medical Center

NCT03512405

ACTIVE NOT RECRUITING Phase 1 35 participants

Trial Treating Relapsed Acute Lymphoblastic Leukemia With Venetoclax and Navitoclax

St. Jude Children's Research Hospital

NCT05192889

ACTIVE NOT RECRUITING Phase 1 33 participants

Study of CD19/CD22 Chimeric Antigen Receptor (CAR) T Cells in Children and Young Adults w/ Recurrent or Refractory B Cell Malignancies

Stanford University

NCT03241940

ACTIVE NOT RECRUITING Phase 1 32 participants

Palbociclib and Sorafenib, Decitabine, or Dexamethasone in Treating Patients With Recurrent or Refractory Leukemia

M.D. Anderson Cancer Center

NCT03132454

ACTIVE NOT RECRUITING Phase 1 23 participants

CART22 Alone or in Combination With huCART19 for ALL

University of Pennsylvania

NCT03620058

ACTIVE NOT RECRUITING Phase 2 22 participants

Low-Intensity Chemotherapy, Ponatinib and Blinatumomab in Treating Patients With Philadelphia Chromosome-Positive and/or BCR-ABL Positive Acute Lymphoblastic Leukemia

M.D. Anderson Cancer Center

NCT03147612

COMPLETED Phase 2 11 participants

Vyxeos(CPX-351) in Adults w R/R Acute Lymphoblastic Leukemia

H. Lee Moffitt Cancer Center and Research Institute

NCT03575325

Phase Distribution

PhaseTrial count
Phase 1 15
Phase 2 7

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Refractory Acute Lymphoblastic Leukemia Trial Landscape

22 indexed Refractory Acute Lymphoblastic Leukemia studies · 12 recruiting (55%).

Phase mix: 0 late (III/IV) vs 22 early (I/II).

Top sponsor: M.D. Anderson Cancer Center (5 trials), 9 others listed. 22 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Refractory Acute Lymphoblastic Leukemia?

PlainTrial tracks 22 US clinical trials for Refractory Acute Lymphoblastic Leukemia, of which 12 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Refractory Acute Lymphoblastic Leukemia?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.