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NCT06287528 · ClinicalTrials.gov registry record · Phase 1
A Study of 19-28z/IL-18 in People With Acute Lymphoblastic Leukemia (ALL)
A Phase 1 study of Refractory Acute Lymphoblastic Leukemia and Refractory Acute Lymphoblastic Leukemia (ALL), sponsored by Memorial Sloan Kettering Cancer Center.
- Recruiting
- Registry status
- Phase 1
- Development phase
- 18
- Enrollment target
- 7
- Study locations
NCT06287528 is a Phase 1 study of Refractory Acute Lymphoblastic Leukemia and Refractory Acute Lymphoblastic Leukemia (ALL) that is actively recruiting participants, run by Memorial Sloan Kettering Cancer Center. The registered enrollment target is 18 participants, below the 44-participant average among 21 other Refractory Acute Lymphoblastic Leukemia trials with a reported enrollment target (59% lower). The trial reports 7 study locations across 2 states.
The verdict
NCT06287528, a Phase 1 study of Refractory Acute Lymphoblastic Leukemia and Refractory Acute Lymphoblastic Leukemia (ALL), is actively recruiting participants, sponsored by Memorial Sloan Kettering Cancer Center.
- RECRUITING
- Registry status
- Phase 1
- Development phase
- 18 participants
- Enrollment target
- 7
- Study locations
Study Summary
Participants will have a sample of their white blood cells, called T cells, collected using a procedure called leukapheresis. The collected T cells will be sent to a laboratory to be changed (modified) to become 19-28z/IL-18, the CAR T-cell therapy that participants will receive during the study. Making the participants' study therapy will take about 2-4 weeks.
Conditions Studied
Interventions
- BIOLOGICAL 19-28z/IL-18 CAR T cells
Study Locations (7)
New York
- Memorial Sloan Kettering Cancer Suffolk-Commack (Limited Protocol Activities) - Commack
- Memorial Sloan Kettering Westchester (Limited Protocol Activities) - Harrison
- Memorial Sloan Kettering Cancer Center (All Protocol Activities) - New York
- Memorial Sloan Kettering Nassau (Limited Protocol Activities) - Uniondale
New Jersey
- Memorial Sloan Kettering at Basking Ridge (Limited Protocol Activities) - Basking Ridge
- Memorial Sloan Kettering Monmouth (Limited Protocol Activities) - Middletown
- Memorial Sloan Kettering Bergen (Limited Protocol Activities) - Montvale
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 18 participants |
| Start Date | 2024-02-23 |
| Est. Completion | 2028-02-23 |
| Phase | Phase 1 |
Interested in This Trial?
Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT06287528
The ClinicalTrials.gov registry entry for NCT06287528 describes a study currently listed as recruiting, categorized as Phase 1. The registered enrollment target is 18 participants, a figure that helps gauge the scale of data the investigators plan to collect, below the 44-participant average among 21 other Refractory Acute Lymphoblastic Leukemia trials with a reported enrollment target (59% lower). The listed sponsor is Memorial Sloan Kettering Cancer Center, which has 1,884 total studies on file at ClinicalTrials.gov.
The record links to 6 conditions, with Refractory Acute Lymphoblastic Leukemia appearing as the primary indexed condition, and to 1 intervention - of which 19-28z/IL-18 CAR T cells is the first listed.
NCT06287528 reports 7 study locations spanning 2 distinct geographic areas - top geographies include New York, New Jersey.
Frequently Asked Questions
What is clinical trial NCT06287528 about?
NCT06287528 is a clinical study titled "A Study of 19-28z/IL-18 in People With Acute Lymphoblastic Leukemia (ALL)". Participants will have a sample of their white blood cells, called T cells, collected using a procedure called leukapheresis. The collected T cells will be sent to a laboratory to be changed (modified) to become 19-28z/IL-18, the CAR T-cell therapy that participants will receive during the study. Ma...
What is the current status of trial NCT06287528?
This trial is currently recruiting. It is a Phase 1 study. The enrollment target is 18 participants. The study started on 2024-02-23. Estimated completion is 2028-02-23.
What conditions does trial NCT06287528 study?
This clinical trial studies the following conditions: Refractory Acute Lymphoblastic Leukemia, Refractory Acute Lymphoblastic Leukemia (ALL), Philadelphia-Negative ALL, Philadelphia-Positive ALL, Relapsed ALL, Adult.
What interventions are being tested in trial NCT06287528?
The interventions under investigation include: 19-28z/IL-18 CAR T cells (BIOLOGICAL).
Who is sponsoring clinical trial NCT06287528?
This trial is sponsored by Memorial Sloan Kettering Cancer Center, which has 1,884 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06287528 being conducted?
This trial has 7 study locations across New Jersey, New York. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page mirrors this trial's own ClinicalTrials.gov registry record, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.