Medical Information Only. Consult your healthcare provider before considering clinical trial enrollment.

ClinicalTrials.gov 2 recruiting now early-phase tilt small index

Refractive Errors: early-phase trial registry

2 of 15 indexed Refractive Errors trials are currently recruiting, with more weight in Phase 1-2.

Corpus placement: #1,140 of 28,707 conditions by registered trial count.

15 US clinical trials · 2 currently recruiting · #1,140 of 28,707 conditions by registered trial count

Refractive Errors: 15 US clinical trials tracked, 2 recruiting.

Refractive Errors is the subject of 15 registered US clinical trials on ClinicalTrials.gov, 2 of them currently open to new participants. 0 are in Phase 3-4 (later-stage) and 1 in Phase 1-2 (earlier-stage). The most active sponsor is Alcon Research, running 9 of these trials.

Enrollment posture brief

Registry condition refractive-errors

OPEN 2 | RECR 13% | LATE 0 | EARLY 1 | RANK #1140 | SPON 9

Nearest open-share peer: Drug Addiction (13% recruiting · 15 trials)

Advanced Lung Non-Small Cell53.3%AIDS26.7%Refractive Errors (this)13%Adult Acute Myeloid Leukemia0%Adult Glioblastoma0%
Open-enrollment share among volume-matched conditions near Refractive Errors

Refractive Errors lists 2 open slots (13% of 15 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →

Key findings

What ClinicalTrials.gov does not surface for Refractive Errors on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.

  1. Refractive Errors is recruiting below its size-band peers.

    2 of 15 indexed trials (13.3%) are open to enrollment, against a 46.5% average across 27,806 conditions with fewer than 20 trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.

  2. One sponsor concentrates Refractive Errors research.

    Alcon Research accounts for 9 of 15 trials (60%). 7 distinct sponsors appear on at least one study for this condition label.

  3. Most Refractive Errors trials plan to enrol fewer than 100 people.

    Median target enrolment is 68 among the 15 trials that report a genuine target (sentinel values excluded). 10 of those (66.7%) plan for fewer than 100 participants.

  4. Refractive Errors research is mostly interventional.

    12 interventional and 3 observational studies make up this index (80% interventional). Study type is sponsor-reported on ClinicalTrials.gov.

Phase 21

Open and recent trials

15 total, page 1 of 1

RECRUITING 60 participants

Corneal Elastography and Patient Specific Modeling

The Cleveland Clinic

NCT03030755

RECRUITING 33 participants

To Study the Effects of Refractive Surgery on OCT Measurements in the Eye

University of Nebraska

NCT05856786

COMPLETED NA 323 participants

Clinical Assessment of a HYDRAGLYDE® Regimen

Alcon, a Novartis Company

NCT03026257

COMPLETED 312 participants

Air Optix Daily Wear Contact Lenses

Alcon Research

NCT05827224

COMPLETED NA 188 participants

Assessing Fitting Guides in Alcon Multifocal Contact Lenses

Alcon Research

NCT03118934

COMPLETED NA 112 participants

Clinical Performance of Two Commercial, Daily Disposable Contact Lenses

Alcon Research

NCT05010512

COMPLETED NA 107 participants

DD T2 Daily Disposable Registration Trial

Alcon Research

NCT03305770

COMPLETED NA 92 participants

Investigation of the Accuracy of an Automated Refractor to Provide Well-tolerated Eyeglass Prescriptions

PlenOptika

NCT06883032

COMPLETED NA 88 participants

Clinical Performance of a Monthly Replacement Silicone Hydrogel Lens

Alcon Research

NCT03586167

COMPLETED Phase 2 68 participants

Evaluation of the Safety and Effectiveness of Aceclidine/Brimonidine (LNZ101) and Aceclidine (LNZ100) in the Treatment of Presbyopia

LENZ Therapeutics

NCT05294328

COMPLETED NA 39 participants

Clinical Characterization of an Investigational Frequent Replacement Daily Wear Silicone Hydrogel Sphere Contact Lens

Alcon Research

NCT04702984

COMPLETED NA 36 participants

Three Daily Wear Monthly Replacement Silicone Hydrogel Contact Lenses With Two Multi-purpose Disinfecting Solution Combinations

Alcon Research

NCT04789382

COMPLETED NA 18 participants

Assessing the Clinical Performance of Two Frequent Replacement Silicone Hydrogel Multifocal Toric Contact Lenses

Alcon Research

NCT05886907

COMPLETED NA 12 participants

Clinical Performance of a Silicone Hydrogel Contact Lens Following One Night of Extended Wear

Alcon Research

NCT03560141

COMPLETED 10 participants

Early Feasibility Study to Evaluate the AccuraSee in Correcting Residual Refractive Errors After Cataract Surgery

OnPoint Vision

NCT05113979

Phase Distribution

PhaseTrial count
Phase 2 1

Top Sponsors

Named interventions

Most-linked intervention names on Refractive Errors records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.

OPTI-FREE multipurpose solution Device
1 trials
LID021201 contact lenses Device
1 trials
PV+Biotrue Device
1 trials
Biofinity+RepleniSH Device
1 trials
LID018869+Biotrue Device
1 trials
LID018869+RepleniSH Device
1 trials
AccuraSee IOPCL with +3.0D add Device
1 trials
Comfilcon A toric soft contact lenses Device
1 trials

US sites by state

Facility locations filed on Refractive Errors trials. A trial with sites in several states counts in each.

Tennessee 8 trials
Florida 7 trials
Minnesota 4 trials
Texas 3 trials
Ohio 3 trials
Illinois 3 trials
Georgia 3 trials
California 3 trials

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

What to do with this Refractive Errors page

15 registered trials, 2 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.

  • 2 Refractive Errors trials are currently recruiting, check eligibility criteria before contacting a site. Browse recruiting trials
  • Alcon Research sponsors the most Refractive Errors trials on record, review their full trial history before evaluating a specific study. See Alcon Research's trials
  • Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide

Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This Refractive Errors condition card totals 15 registered trials; most-linked intervention OPTI-FREE multipurpose solution; top US site state Tennessee. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.