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ClinicalTrials.gov 19 recruiting now official registry

Recurrent Diffuse Large B-Cell Lymphoma clinical trials

19 of 44 indexed Recurrent Diffuse Large B-Cell Lymphoma trials are currently recruiting.

44 US clinical trials · 19 currently recruiting

Recurrent Diffuse Large B-Cell Lymphoma is the subject of 44 registered US clinical trials on ClinicalTrials.gov, 19 of them currently open to new participants. 0 are in Phase 3-4 (later-stage) and 43 in Phase 1-2 (earlier-stage). The most active sponsor is City of Hope Medical Center, running 10 of these trials.

The research picture

Recurrent Diffuse Large B-Cell Lymphoma has 44 registered US clinical trials, 19 of them open to new participants right now, about 43% of the total.

19
recruiting participants now
43%
of trials open to enrollment
0
in Phase 3–4 (later-stage)
10
top sponsor: City of Hope Medical Center
Phase 130Phase 213

Active & Recent Trials

44 total, page 1 of 1

RECRUITING Phase 2 396 participants

Testing Drug Treatments After CAR T-cell Therapy in Patients With Relapsed/Refractory Diffuse Large B-cell Lymphoma

SWOG Cancer Research Network

NCT05633615

RECRUITING Phase 2 227 participants

Study Adding Drugs to Usual Treatment for Large B-Cell Lymphoma That Returned or Did Not Respond to Treatment

SWOG Cancer Research Network

NCT05890352

RECRUITING Phase 2 120 participants

Testing the Effectiveness of a Combination Targeted Therapy (ViPOR) for Patients With Relapsed and/or Refractory Aggressive B-cell Lymphoma

National Cancer Institute (NCI)

NCT06649812

RECRUITING Phase 2 80 participants

Ascorbic Acid and Chemotherapy for the Treatment of Relapsed or Refractory Lymphoma, CCUS, and Chronic Myelomonocytic Leukemia

Mayo Clinic

NCT03418038

RECRUITING Phase 2 56 participants

Fecal Microbiome Transplant to Remodel Intestinal Microbiota for Patients With Relapsed or Refractory Lymphoma With Exposure to High-Risk Antibiotics Who Are Receiving Chimeric Antigen Receptor T Cells

City of Hope Medical Center

NCT07042438

RECRUITING Phase 2 40 participants

Loncastuximab Tesirine for the Treatment of Relapsed or Refractory B-Cell Malignancies

University of Washington

NCT05453396

RECRUITING Phase 1 38 participants

Epcoritamab Plus Ibrutinib for the Treatment of Relapsed or Refractory Aggressive B-Cell Non-Hodgkin Lymphoma

Yazeed Sawalha

NCT06536049

RECRUITING Phase 1 37 participants

Zanubrutinib in Combination With Sonrotoclax for the Treatment of Underrepresented Ethnic and Racial Minorities With Relapsed or Refractory B-cell Non-Hodgkin Lymphoma

City of Hope Medical Center

NCT06859008

RECRUITING Phase 1 36 participants

Fludarabine and Cyclophosphamide With or Without Rituximab Before CD19 Chimeric Antigen Receptor T Cells for the Treatment of Relapsed or Refractory Diffuse Large B-Cell Lymphoma

Mehrdad Abedi, MD

NCT05052528

RECRUITING Phase 2 36 participants

Loncastuximab Tesirine and Mosunetuzumab for the Treatment of Relapsed or Refractory Diffuse Large B-Cell Lymphoma

City of Hope Medical Center

NCT05672251

RECRUITING Phase 2 34 participants

Odronextamab for the Treatment of Relapsed and Refractory Diffuse Large B-cell Lymphoma Before and After Chimeric Antigen Receptor T-cell Therapy

Joseph Tuscano

NCT06854159

RECRUITING Phase 1 33 participants

ST-067 in Combination With CD19-Directed CAR T-Cell Therapy (Liso-cel) in Relapsed/Refractory Large B-Cell Lymphoma

Fred Hutchinson Cancer Center

NCT07098364

RECRUITING Phase 1 32 participants

Testing the Combination of Nivolumab and ASTX727 for Relapsed or Refractory B-Cell Lymphoma

National Cancer Institute (NCI)

NCT05272384

RECRUITING Phase 2 27 participants

Odronextamab for Relapsed and Refractory Large B-cell Lymphomas Before CAR-T

University of Washington

NCT06784726

RECRUITING Phase 1 27 participants

B-Cell Activating Factor Receptor (BAFFR)-Based Chimeric Antigen Receptor T-Cells With Fludarabine and Cyclophosphamide Lymphodepletion for the Treatment of Relapsed or Refractory B-cell Hematologic Malignancies

Mayo Clinic

NCT06191887

RECRUITING Phase 2 25 participants

Epcoritamab Plus Standard of Care Platinum-Based Chemotherapy and Autologous Hematopoietic Cell Transplant for the Treatment of Relapsed or Refractory Large B-cell Lymphoma

Joseph Tuscano

NCT06905509

RECRUITING Phase 1 20 participants

Immune Cell Therapy (CAR-T) for the Treatment of Patients With HIV and B-Cell Non-Hodgkin Lymphoma

AIDS Malignancy Consortium

NCT05077527

RECRUITING Phase 1 15 participants

Genetically Modified T-cells (CMV-Specific CD19-CAR T-cells) Plus a Vaccine (CMV-MVA Triplex) Following Stem Cell Transplantation for the Treatment of Intermediate or High Grade B-cell Non-Hodgkin Lymphoma

City of Hope Medical Center

NCT05432635

RECRUITING Early Phase 1 9 participants

Evaluation of Bridging Radiation Therapy Before CAR T-Cell Infusion for the Treatment of Relapsed or Refractory Large B-Cell Lymphoma

City of Hope Medical Center

NCT05800405

ACTIVE NOT RECRUITING Phase 2 53 participants

Rituximab and Pembrolizumab With or Without Lenalidomide in Treating Patients With Relapsed Follicular Lymphoma and Diffuse Large B-Cell Lymphoma

M.D. Anderson Cancer Center

NCT02446457

ACTIVE NOT RECRUITING Phase 1 53 participants

A Phase I/II Study to Evaluate the Safety of Cellular Immunotherapy Using Autologous T Cells Engineered to Express a CD20-Specific Chimeric Antigen Receptor for Patients With Relapsed or Refractory B Cell Non-Hodgkin Lymphomas

Fred Hutchinson Cancer Center

NCT03277729

ACTIVE NOT RECRUITING Phase 1 52 participants

Pembrolizumab and Vorinostat in Patients With Relapsed or Refractory DLBCL, FCL or HL.

City of Hope Medical Center

NCT03150329

ACTIVE NOT RECRUITING Phase 1 51 participants

Memory Enriched T Cells Following Stem Cell Transplant in Treating Patients With Recurrent B-Cell Non-Hodgkin Lymphoma

City of Hope Medical Center

NCT02051257

ACTIVE NOT RECRUITING Phase 2 41 participants

Polatuzumab Vedotin, Rituximab, Ifosfamide, Carboplatin, and Etoposide (PolaR-ICE) as Initial Salvage Therapy for the Treatment of Relapsed/Refractory Diffuse Large B-Cell Lymphoma

City of Hope Medical Center

NCT04665765

ACTIVE NOT RECRUITING Phase 1 39 participants

Lenalidomide and Ibrutinib in Treating Patients With Relapsed or Refractory B-Cell Non-Hodgkin Lymphoma

National Cancer Institute (NCI)

NCT01955499

ACTIVE NOT RECRUITING Phase 1 37 participants

Cellular Immunotherapy Following Chemotherapy in Treating Patients With Recurrent Non-Hodgkin Lymphomas, Chronic Lymphocytic Leukemia, or B-Cell Prolymphocytic Leukemia

City of Hope Medical Center

NCT02153580

ACTIVE NOT RECRUITING Phase 1 36 participants

Nivolumab and Lenalidomide in Treating Patients With Relapsed or Refractory Non-Hodgkin or Hodgkin Lymphoma

David Bond, MD

NCT03015896

ACTIVE NOT RECRUITING Phase 1 30 participants

R-ICE and Lenalidomide in Treating Patients With First-Relapse/Primary Refractory Diffuse Large B-Cell Lymphoma

Academic and Community Cancer Research United

NCT02628405

ACTIVE NOT RECRUITING Phase 1 29 participants

Carfilzomib, Rituximab, Ifosfamide, Carboplatin, and Etoposide in Treating Patients With Relapsed or Refractory Stage I-IV Diffuse Large B-cell Lymphoma

Roswell Park Cancer Institute

NCT01959698

ACTIVE NOT RECRUITING Phase 1 27 participants

NKTR-255 in Combination With CAR-T Cell Therapy for the Treatment of Relapsed or Refractory Large B-cell Lymphoma

Fred Hutchinson Cancer Center

NCT05359211

ACTIVE NOT RECRUITING Phase 1 24 participants

Modified Immune Cells (CD19/CD20 CAR-T Cells) in Treating Patients With Recurrent or Refractory B-Cell Lymphoma or Chronic Lymphocytic Leukemia

Jonsson Comprehensive Cancer Center

NCT04007029

ACTIVE NOT RECRUITING Phase 1 24 participants

Testing the Addition of an Immunotherapy Agent, Atezolizumab, When Given With the Usual Chemo-Immunotherapy Drug Combination (Rituximab Plus Gemcitabine and Oxaliplatin) for Relapsed/Refractory (That Has Come Back or Not Responded to Treatment) Transformed Diffuse Large B-Cell Lymphoma

National Cancer Institute (NCI)

NCT03321643

ACTIVE NOT RECRUITING Phase 1 22 participants

Obinutuzumab, Venetoclax, and Lenalidomide in Treating Patients With Relapsed or Refractory B-cell Non-Hodgkin Lymphoma

Beth Christian

NCT02992522

ACTIVE NOT RECRUITING Phase 2 20 participants

Nivolumab for Relapsed, Refractory, or Detectable Disease Post Chimeric Antigen Receptor T-cell Treatment in Patients With Hematologic Malignancies

University of Washington

NCT04205409

ACTIVE NOT RECRUITING Phase 1 18 participants

Pevonedistat and Ibrutinib in Treating Participants With Relapsed or Refractory CLL or Non-Hodgkin Lymphoma

City of Hope Medical Center

NCT03479268

COMPLETED Phase 1 60 participants

Fludarabine, Bendamustine, and Rituximab in Treating Participants With Lymphoid Cancers Undergoing Stem Cell Transplant

M.D. Anderson Cancer Center

NCT00880815

COMPLETED Phase 1 50 participants

Olaparib and High-Dose Chemotherapy in Treating Patients With Relapsed or Refractory Lymphomas Undergoing Stem Cell Transplant

M.D. Anderson Cancer Center

NCT03259503

COMPLETED Early Phase 1 35 participants

Tumor-Specific Clonotype, Metabolic Profile, and PET/CT in Predicting Chemotherapy Response in Patients With Relapsed or Refractory Diffuse Large B-cell Lymphoma

M.D. Anderson Cancer Center

NCT02405078

COMPLETED Phase 1 26 participants

Ibrutinib and Combination Chemotherapy in Treating Patients With Relapsed or Refractory Diffuse Large B-cell Lymphoma

National Cancer Institute (NCI)

NCT02219737

COMPLETED 23 participants

Hypoxia-Specific Imaging to Predict Outcomes of Chimeric Antigen Receptor T-cell Therapy

University of California, San Francisco

NCT04409314

COMPLETED Phase 1 11 participants

Dendritic Cell Therapy, Cryosurgery, and Pembrolizumab in Treating Patients With Non-Hodgkin Lymphoma

Mayo Clinic

NCT03035331

COMPLETED Phase 1 8 participants

Mogamulizumab and Pembrolizumab in Treating Patients With Relapsed or Refractory Diffuse Large B Cell Lymphoma

National Cancer Institute (NCI)

NCT03309878

COMPLETED Phase 1 7 participants

Duvelisib and Nivolumab in Treating Patients With Richter Syndrome or Transformed Follicular Lymphoma

David Bond, MD

NCT03892044

COMPLETED Early Phase 1 4 participants

Duvelisib Exposure to Enhance Immune Profiles of T Cells in Patients With Recurrent or Refractory Diffuse Large B-Cell Lymphoma, DEEP T CELLS Study

Emory University

NCT04890236

Phase Distribution

PhaseTrial count
Phase 1 30
Phase 2 13

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Recurrent Diffuse Large B-Cell Lymphoma Trial Landscape

44 indexed Recurrent Diffuse Large B-Cell Lymphoma studies · 19 recruiting (43%).

Phase mix: 0 late (III/IV) vs 43 early (I/II).

Top sponsor: City of Hope Medical Center (10 trials), 9 others listed. 44 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Recurrent Diffuse Large B-Cell Lymphoma?

PlainTrial tracks 44 US clinical trials for Recurrent Diffuse Large B-Cell Lymphoma, of which 19 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Recurrent Diffuse Large B-Cell Lymphoma?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.