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ClinicalTrials.gov 4 recruiting now official registry

Prosthetic-joint Infection clinical trials

4 of 10 indexed Prosthetic-joint Infection trials are currently recruiting.

10 US clinical trials · 4 currently recruiting

Prosthetic-joint Infection is the subject of 10 registered US clinical trials on ClinicalTrials.gov, 4 of them currently open to new participants. 2 are in Phase 3-4 (later-stage) and 4 in Phase 1-2 (earlier-stage). The most active sponsor is Osteal Therapeutics, running 2 of these trials.

The research picture

Prosthetic-joint Infection has 10 registered US clinical trials, 4 of them open to new participants right now, about 40% of the total.

4
recruiting participants now
40%
of trials open to enrollment
2
in Phase 3–4 (later-stage)
2
top sponsor: Osteal Therapeutics
Phase 11Phase 23Phase 42

Active & Recent Trials

10 total, page 1 of 1

RECRUITING Phase 2 240 participants

Evaluation of PLG0206 in Prevention of Recurrent Infection in Patients Undergoing Debridement, Antibiotics, and Implant Retention (DAIR) for Treatment of a Periprosthetic Joint Infection (PJI) Following Knee Arthroplasty

Peptilogics

NCT07214311

RECRUITING NA 153 participants

Real-component Vs All-cement Articulating Spacers for Periprosthetic Knee Infection

Northwestern University

NCT06293352

RECRUITING NA 152 participants

The Effect of Peri-Operative Adjunctive Probiotics on Immunological Markers in Cases of Prosthetic Joint Infection of the Hip and Knee

NYU Langone Health

NCT06919913

RECRUITING NA 60 participants

Reduction of Bacterial Seeding in Total Shoulder Arthroplasty

St. Louis University

NCT07406893

COMPLETED NA 80 participants

Study of Antibiotic Spacer Design to Treat Infection After Hip Replacement

Rush University Medical Center

NCT01373099

COMPLETED Phase 2 76 participants

A Second Trial of the Abbreviated Protocol Two-Stage Exchange

Osteal Therapeutics

NCT05607030

COMPLETED Phase 4 60 participants

SURGX Antimicrobial Gel Versus Povidone-iodine Skin Incision Prep in Total Shoulder Arthroplasty

St. Louis University

NCT05919888

COMPLETED Phase 4 41 participants

Dalbavancin For The Treatment of Gram Positive Osteoarticular Infections

Infectious Diseases Physicians

NCT03426761

COMPLETED Phase 2 15 participants

Safety and Efficacy in Patients Treated for Hip or Knee PJI With Vancomycin and Tobramycin Joint Irrigation

Osteal Therapeutics

NCT03721328

COMPLETED Phase 1 13 participants

Tissue Distribution, Pharmacokinetics, Safety, and Tolerability After a Single Dose of TNP-2092 in Participants Undergoing Primary Total Hip or Knee Arthroplasty

TenNor Therapeutics Limited

NCT04294862

Phase Distribution

PhaseTrial count
Phase 1 1
Phase 2 3
Phase 4 2

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Prosthetic-joint Infection Trial Landscape

10 indexed Prosthetic-joint Infection studies · 4 recruiting (40%).

Phase mix: 2 late (III/IV) vs 4 early (I/II).

Top sponsor: Osteal Therapeutics (2 trials), 7 others listed. 10 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Prosthetic-joint Infection?

PlainTrial tracks 10 US clinical trials for Prosthetic-joint Infection, of which 4 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Prosthetic-joint Infection?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.