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ClinicalTrials.gov 39 recruiting now official registry

Posttraumatic Stress Disorder clinical trials

39 of 119 indexed Posttraumatic Stress Disorder trials are currently recruiting.

119 US clinical trials · 39 currently recruiting

Posttraumatic Stress Disorder is the subject of 119 registered US clinical trials on ClinicalTrials.gov, 39 of them currently open to new participants. 9 are in Phase 3-4 (later-stage) and 16 in Phase 1-2 (earlier-stage). The most active sponsor is VA Office of Research and Development, running 26 of these trials.

The research picture

Posttraumatic Stress Disorder has 119 registered US clinical trials, 39 of them open to new participants right now, about 33% of the total.

39
recruiting participants now
33%
of trials open to enrollment
9
in Phase 3–4 (later-stage)
26
top sponsor: VA Office of Research and Development
Phase 17Phase 29Phase 33Phase 46

Active & Recent Trials

119 total, page 3 of 3

COMPLETED NA 31 participants

Online Intervention to Promote Resilience to Traumatic Stress During Pregnancy

University of Illinois at Chicago

NCT04992767

COMPLETED NA 30 participants

Mobile Intervention for Veterans With PTSD and Anger

VA Office of Research and Development

NCT03733028

COMPLETED NA 30 participants

MGH Trauma-related Nightmares SDI Study

Massachusetts General Hospital

NCT05195684

COMPLETED Phase 4 26 participants

A Study of Sertraline to Prevent PTSD

Massachusetts General Hospital

NCT00182078

COMPLETED Phase 4 23 participants

A Psychophysiologic Study of Weakening Traumatic Combat Memories With Post-Reactivation Propranolol

Massachusetts General Hospital

NCT00709735

COMPLETED Phase 2 23 participants

MDMA-Assisted Psychotherapy in People With Posttraumatic Stress Disorder

Lykos Therapeutics

NCT00090064

COMPLETED NA 22 participants

Treating Co-Morbid Sleep Difficulties in Veterans With Posttraumatic Stress Disorder (PTSD): A Pilot Study

Durham VA Medical Center

NCT00734799

COMPLETED NA 21 participants

Treating Violence-related PTSD and Substance Risk in Low-income, Urban Adolescents

State University of New York at Buffalo

NCT03737383

COMPLETED NA 20 participants

Building Resilience After Childhood Emergencies (BRACE)

Case Western Reserve University

NCT02898883

COMPLETED Phase 4 18 participants

An Open Label Pilot Study of Adjunctive Asenapine for the Treatment of Posttraumatic Stress Disorder

Lori Davis, MD

NCT01587118

COMPLETED NA 16 participants

Reducing PTSD in Hospitalized Burn Patients

University of Southern California

NCT02026037

COMPLETED NA 12 participants

A Self-Management Program for Completers of Trauma-Focused Therapy for PTSD

VA Office of Research and Development

NCT03225859

COMPLETED Phase 4 11 participants

Reducing Cannabis Overuse With Prazosin

VA Puget Sound Health Care System

NCT04721353

COMPLETED Phase 1 9 participants

Norepinephrine Transporter Availability in PTSD

Emory University

NCT01799837

COMPLETED NA 9 participants

Narrative Exposure Therapy (NET)

VA Office of Research and Development

NCT03777553

COMPLETED NA 8 participants

Targeted Strategies to Accelerate Evidence-Based Psychotherapy (EBP) Implementation in Military Settings

Palo Alto Veterans Institute for Research

NCT03663452

COMPLETED NA 6 participants

Using Attentional Bias Modification to Address Trauma Symptoms

University of Nebraska Lincoln

NCT02615717

COMPLETED NA 6 participants

Lifespan Integration for Posttraumatic Stress Disorder From an Auto Accident

Argosy University

NCT01263067

COMPLETED NA

Intervention to Decrease Anxiety in Parents of Infants in the Neonatal Intensive Care Unit (NICU)

Stanford University

NCT00186472

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Phase Distribution

PhaseTrial count
Phase 1 7
Phase 2 9
Phase 3 3
Phase 4 6

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Posttraumatic Stress Disorder Trial Landscape

119 indexed Posttraumatic Stress Disorder studies · 39 recruiting (33%).

Phase mix: 9 late (III/IV) vs 16 early (I/II).

Top sponsor: VA Office of Research and Development (26 trials), 9 others listed. 19 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Posttraumatic Stress Disorder?

PlainTrial tracks 119 US clinical trials for Posttraumatic Stress Disorder, of which 39 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Posttraumatic Stress Disorder?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.