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NCT01090180 · ClinicalTrials.gov registry record · NA
Extinction of Fear Memories With Glucocorticoids in Veterans With PTSD
A NA study of Post Traumatic Stress Disorder, sponsored by VA Office of Research and Development.
- Completed
- Registry status
- NA
- Development phase
- 129
- Enrollment target
- 1
- Study location
NCT01090180: Completed NA study of Post Traumatic Stress Disorder, sponsored by VA Office of Research and Development.
NCT01090180 is a NA study of Post Traumatic Stress Disorder that has completed, run by VA Office of Research and Development. The registered enrollment target is 129 participants, below the 663-participant average among 262 other Post Traumatic Stress Disorder trials with a reported enrollment target (81% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT01090180, a NA study of Post Traumatic Stress Disorder, has completed, sponsored by VA Office of Research and Development.
- COMPLETED
- Registry status
- NA
- Development phase
- 129 participants
- Enrollment target
- 1
- Study location
Study Summary
The purpose of this study is to examine the effects of glucocorticoid administration following traumatic memory reactivation on psychiatric symptoms in veterans with combat-related PTSD, in addition to examining the effects of glucocorticoid administration following traumatic memory reactivation on physiological responses to veteran's personal combat memories. The following hypotheses will be tested: 1. Subjects who receive an exogenous glucocorticoid after traumatic memory reactivation will demonstrate fewer PTSD and depression symptoms one week later, compared to those who receive a placebo after traumatic memory reactivation. 2. The glucocorticoid reduction effects will be cumulative; that is, reduction will persist, and further post-reactivation glucocorticoid administration will further reduce symptoms 3. Decreases in PTSD and depression symptoms will persist at 1, 3, and 6 months for subjects receiving an exogenous glucocorticoid compared to those subjects receiving placebo 4. Subjects who receive an exogenous glucocorticoid after traumatic memory reactivation will demonstrate decreased physiological responses one week later, compared to those who receive a placebo after traumatic memory reactivation. 5. As with the psychological measures, suppression of the physiological measures will demonstrate both persistence over time and accumulation with subsequent post-reactivation glucocorticoid administration.
Primary Outcome
The PCL is a 17-item measure of PTSD symptom severity with a range from 17-85. Each item is rated from 1-5 with higher scores are indicative of higher symptom severity. Scores of the 17 items are summed in order to generate the total score.
Conditions Studied
Interventions
- DRUG Dexamethasone
- DRUG Placebo (sugar pill)
Study Locations (1)
Texas
- VA North Texas Health Care System, Dallas - Dallas
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 129 participants |
| Start Date | 2010-04 |
| Est. Completion | 2013-09 |
| Phase | NA |
What the finished NCT01090180 record still lists
NCT01090180 is an interventional study that assigns participants to a tested intervention. The registered 129 participants enrollment target is mid-sized for trials with a published cap, below the 663-participant average among 262 other Post Traumatic Stress Disorder trials with a reported enrollment target (81% lower).
The record links to 1 condition, with Post Traumatic Stress Disorder appearing as the primary indexed condition, and to 2 interventions - of which Dexamethasone is the first listed.
NCT01090180 reports a single indexed study location in Texas.
Frequently Asked Questions
What is clinical trial NCT01090180 about?
NCT01090180 is a clinical study titled "Extinction of Fear Memories With Glucocorticoids in Veterans With PTSD". The purpose of this study is to examine the effects of glucocorticoid administration following traumatic memory reactivation on psychiatric symptoms in veterans with combat-related PTSD, in addition to examining the effects of glucocorticoid administration following traumatic memory reactivation on ...
What is the current status of trial NCT01090180?
This trial is currently completed. It is a NA study. The enrollment target is 129 participants. The study started on 2010-04. Estimated completion is 2013-09.
What conditions does trial NCT01090180 study?
This clinical trial studies the following conditions: Post Traumatic Stress Disorder.
What interventions are being tested in trial NCT01090180?
The interventions under investigation include: Dexamethasone (DRUG), Placebo (sugar pill) (DRUG).
Who is sponsoring clinical trial NCT01090180?
This trial is sponsored by VA Office of Research and Development, which has 1,668 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT01090180 being conducted?
This trial has 1 study location across Texas. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
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Where NCT01090180's enrollment target sits among peer trials
129 93rd of 262 higher than 170 of 262 other Post Traumatic Stress Disorder trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Post Traumatic Stress Disorder trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
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